YARC       Comparative Medicine

Veterinary Clinical Services


Anti-Infectives A - C


Acyclovir

Bird 80 mg/kg BW IM, IV, PO tid (Ritchie and Harrison, 1997)
20 mg/kg BW PO bid for 7 days (Ritchie and Harrison, 1997)

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Amantadine

Ferret 6 mg/kg BW as an aerosol bid (Cross, 1995)

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Amikacin

Bird 40 mg/kg BW IM sid or bid (Burke, 1986)
22 mg/kg BW q12h (Schultz, 1989)
10-15 mg/kg BW IM, IV, SC q8-12h (Ritchie and Harrison, 1997)
Cockatiels: 15-20 mg/kg BW IM, IV, SC q8-12h (Ritchie and Harrison, 1997)
Psittacines: 30 mg/kg BW total daily dose (Van der Heyden, 1994)
Pigeons: 15-20 mg/kg BW IM, IV bid (Johnson-Delaney, 1996)
Ratites: 10 mg/kg BW PO bid (Welsh et al., 1997)
Cat 5-7 mg/kg BW IM, IV bid (Boothe, 1996)
15 mg/kg BW IM, IV sid (Boothe, 1996)
Chinchilla 2 mg/kg BW IM, IV, SC tid (Jenkins, 1992)
Dog 7-10 mg/kg BW IM, IV bid (Boothe, 1996)
20 mg/kg BW IM, IV sid (Boothe, 1996)
NHP 2.3 mg/kg BW IM sid (Wissman and Parsons, 1992)
Rabbit 10 mg/kg BW IM, SC q8-12h (Carpenter et al., 1995)
Reptile Tortoises: 5 mg/kg BW IM q48h for 7-14 days (Page and Mautino, 1990)

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Amoxicillin

Bird 150 mg/kg BW IM q6-8h (Ritchie and Harrison, 1997)
Canaries: 300-500 mg/kg BW PO in soft food (Ritchie and Harrison, 1997)
Ratites: 20 mg/kg BW PO bid (Welsh et al., 1997)
Bovine 10 mg/kg BW PO q8-12h (Schultz, 1989)
3-5 mg/lb BW IM, SC sid (Kinsell, 1986)
400 mg/100 lb BW PO bid (Sundlofet al., 1991)
62.5 mg (contents of one prepackaged syringe) into each affected quarter q12h for a maximum of 3 treatments (Sundlofet al., 1991)
Cat 5-10 mg/lb BW PO q12h (Kinsell, 1986)
5 mg/lb BW IM, SC sid (Kinsell, 1986)
11-22 mg/kg BW IM, PO, SC q8-12h (Boothe, 1996)
7 mg/kg BW SC sid (Flecknell, 1996)
Dog 5 mg/lb BW PO q12h (Kinsell, 1986)
5 mg/lb BW SC, IM sid (Kinsell, 1986)
20 mg/kg BW PO bid (Carr, 1997)
7 mg/kg BW SC sid (Flecknell, 1996)
Ferret 11-22 mg/kg BW PO, SC (Messonnier, 1996)
7 mg/kg BW SC sid (Flecknell, 1996)
25-35 mg/kg BW PO bid (Johnson-Delaney, 1996)
Guineapig Toxic (Flecknell, 1987)
Hamster Toxic (Flecknell, 1987)
Mouse 100 mg/kg BW SC, IM bid (Flecknell, 1987)
50 mg/kg BW/day in water for 14 days (Russell et al., 1995)
NHP 7 mg/kg BW SC (Flecknell, 1987)
10 mg/kg BW PO (Flecknell, 1987)
11 mg/kg BW PO bid (Fraser, 1991)
11 mg/kg BW SC, IM sid (Fraser, 1991)
Rat 150 mg/kg BW SC, IM bid (Flecknell, 1987)
Sheep 7 mg/kg BW SC sid (Flecknell, 1996)
Swine 7 mg/kg BW SC sid (Flecknell, 1996)

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Amoxicillin/clavulanate

Bird 125 mg/kg BW PO bid (Ritchie and Harrison, 1997)
Ratites: 10 mg/kg BW PO bid (Welsh et al., 1997)
Cat 13.75-20 mg/kg BW PO bid, tid (Boothe, 1996)
Dog 13.75-20 mg/kg BW PO bid, tid (Boothe, 1996)
Ferret 12.5 mg/kg BW PO bid for 10-14 days Johnson-Delaney; 1996)

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Amphotericin B

Bird 1.5 mg/kg BW IV q8-12h for 3-7 days (Ritchie and Harrison, 1997)
1 mg/ml in sterile water to nebulize 15 min bid (Ritchie and Harrison, 1997)
Cat 0.25-0.5 mg/kg BW 2-3 times/week on alternate days, slow IV, IP with 5% dextrose and water (Kinsell, 1986)
Dog 0.25-0.5 mg/kg BW 2-3 times/week on alternate days, slow IV, IP with 5% dextrose and water (Kinsell, 1986)
0.25-1.0 mg/kg BW IV sid (Johnson et al., 1981)
NHP 0.25-1.0 mg/kg BW IV sid (Johnson et al., 1981)

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Ampicillin

Bird 250 mg/8 oz drinking water (change daily) (Burke, 1986)
100-200 mg/kg BW IM, PO q6-8h (Ritchie and Harrison, 1997)
Emus: 15-20 mg/kg BW IM, PO tid (Ritchie and Harrison, 1997)
Ratites: 5 mg/kg BW IM tid (Welsh et al., 1997)
Bovine Ampicillin trihydrare: 5-10 mg/lb BW IM q8h for up to 7 days (Kinsell, 1986)
Cat Ampicillin sodium: 3 mg/lb BW IV, IM q8-12h (Kinsell, 1986)
Ampicillin trihydrate: 3-8 mg/lb BW IM, SC q8-12h or 10-30 mg/lb BW PO q8-12h (Kinsell, 1986)
22 mg/kg BW IV, PO, SC tid (Hawkins, 1996)
5-10 mg/kg BW IM, IV, SC tid (Boothe, 1996)
10-50 mg/kg BW PO tid (Boothe, 1996)
Dog Ampicillin sodium: 3 mg/lb BW IV, IM q8-12h (Kinsell, 1986)
Ampicillin trihydrate: 3-8 mg/lb BW IM, SC q8-12h or 5-10 mg/lb BW PO q6-8h (Kinsell, 1986)
20 mg/kg BW PO tid (Carr, 1997)
5-10 mg/kg BW IM, IV, SC tid (Boothe, 1996)
10-50 mg/kg BW PO tid (Boothe, 1996)
22 mg/kg BW IV, PO, SC tid (Hawkins, 1996)
Ferret 5 mg/kg BW SC sid (McKellar, 1989)
10-30 mg/kg BW SC bid (Johnson-Delaney, 1996)
Guineapig May cause enterocolitis (Bartlett et al., 1978)
6 mg/kg BW SC tid for 5 days (Young et al., 1987)
Hamster Toxic (Flecknell, 1987)
Mouse 2-10 mg/100 g BW PO bid (Russell et al., 1981)
50-150 mg/kg BW SC bid (Flecknell, 1987)
NHP 30 mg/kg BW IM sid for 5 days (Welshman, 1985)
5 mg/kg BW IM bid (Flecknell, 1987)
20 mg/kg BW IM, IV, PO tid (Johnson et al., 1981)
Rat 50-150 mg/kg BW SC bid (Flecknell, 1987)
50 mg/adult rat IP sid for 10 days (Rettig et al., 1989)
Rabbit 22-44 mg/kg BW PO in divided doses (Bowman and Lang, 1986)
10-25 mg/kg BW IM sid for 5-7 days (Bowman and Lang, 1986)
Reptile 3-6 mg/kg BW IM, SC sid until 48 h beyond recovery (Marcus, 1981)
20 mg/kg BW IC bid for 7-9 days (Snipes, 1984)
Tortoises: 20 mg/kg BW IM sid for 7-14 days (Page and Mautino, 1990)

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Amprolium

Bird 2-4 ml/gal water of 9.6% solution for 5 days (Ritchie and Harrison, 1997)
Bovine 10 mg/kg BW daily in feed for 5 days (Schultz, 1989)
Dog 100-200 mg/kg BW/day PO in food or water for 7-10 days (Kinsell, 1986)

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Apramycin

Swine 150 g/ton of food; use for 14 days (Sundlofet al., 1991)
12.5 mg/kg BW PO sid for 7 days (Mortensen et al., 1996)

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Carbenicillin

Bird 200 mg/kg BW PO bid (Burke, 1986)
100-200 mg/kg BW IM, IV q6-12h (Ritchie and Harrison, 1997)
200 mg/kg BW PO bid (Ritchie and Harrison, 1997)
Dog 10-15 mg/lb BW PO q8h or 5-10 mg/lb BW IV q8h (Kinsell, 1986)
Reptile 100 mg/kg BW initially, then 75 mg/kg IM sid or IV bid (Frye, 1981)
Tortoises: 200-400 mg/kg BW IM q48h for 7-14 days (Page and Mautino, 1990)

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Carnidazole

Bird 30-50 mg/kg BW once; may repeat in 10-14 days (Ritchie and Harrison, 1997)

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Cefadroxil

Bird Ratites: 20 mg/kg BW PO bid (Welsh et al., 1997)

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Cefazolin

Bird 25-50 mg/kg BW IM, IV bid (Ritchie and Harrison, 1997)
Cat 15-25 mg/kg BW IM, IV, SC q4-8h (Boothe, 1996)
Dog 15-25 mg/kg BW IM, IV, SC q4-8h (Boothe, 1996)
Guineapig 100 mg/kg BW IM bid (Fritz et al., 1987)
NHP 25 mg/kg BW IM, IV bid for 7-10 days (Univ. of Washington, 1987)

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Cefotaxime

Bird 75-100 mg/kg BW IM, IV q4-8h (Ritchie and Harrison, 1997)
50-100 mg/kg BW IM, IV tid (Ritchie and Harrison, 1997)
Cat 20-80 mg/kg BW IM, IV qid (Boothe, 1996)
Dog 20-80 mg/kg BW IM, IV qid (Boothe, 1996)
NHP 100-200 mg/kg BW IM tid-qid (Pernikoff and Orkin, 1991)
Reptile Tortoises: 20-40 mg/kg BW IM sid for 7-14 days (Page and Mautino, 1990)

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Cefoxitin

Bird 50-100 mg/kg BW IM, IV bid, tid (Ritchie and Harrison, 1997)
Cat 10-30 mg/kg BW IM, IV, SC qid (Boothe, 1996)
Dog 10-30 mg/kg BW IM, IV, SC qid (Boothe, 1996)

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Ceftazidime

NHP Propithecus: 50 mg/kg BW IM, IV tid (Feeser and White, 1992)
50 mg/kg BW IM tid (Feeser and White, 1992)
Reptile 20 mg/kg BW q72h (Lawrence et al., 1984)

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Ceftiofur

Bird Ratites: 20 mg/kg BW IM bid (Welsh et al., 1997)
Bovine 1.1 mg/kg BW IM sid for up to 5 days (Schultz, 1989)
Dog 2.2-4.4 mg/kg BW SC bid (Hoskins, 1997)

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Ceftizoxime

NHP 75-100 mg/kg BW IM bid for 7 days (Univ. of Washington, 1987)

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Cephalexin

Bird 50 mg/kg BW PO qid (Burke, 1986)
Psittacines: 50-100 mg/kg BW PO tid (Ritchie and Harrison, 1997)
Emus: 35-50 mg/kg BW PO qid (Ritchie and Harrison, 1997)
Quail and ducks: 35-50 mg/kg BW PO q2-3h (Ritchie and Harrison, 1997)
Cat 35 mg/kg BW PO q12h (Kinsell, 1986)
20-40 mg/kg BW PO tid (Hawkins, 1996)
10-30 mg/kg BW PO q6-8h (Boothe, 1996)
10 mg/kg BW SC sid (Flecknell, 1996)
Dog 35 mg/kg BW PO q12h (Kinsell, 1986)
20-40 mg/kg BW PO tid (Carr, 1997)
10-30 mg/kg BW PO q6-8h (Boothe, 1996)
10 mg/kg BW SC sid (Flecknell, 1996)
Ferret 10 mg/kg BW SC sid (Flecknell, 1996)
10-15 mg/kg BW PO bid for 10 days (Johnson-Delaney, 1996)
Gerbil 25 mg/kg BW SC sid (Flecknell, 1996)
Guineapig 50 mg/kg BW IM sid for 14 days (Richardson, 1992)
15 mg/kg BW SC sid (Flecknell, 1996)
Mouse 60 mg/kg BW PO bid (Flecknell, 1987)
15 mg/kg BW IM bid (Flecknell, 1996)
NHP 20 mg/kg BW PO bid (Flecknell, 1987)
Rat 60 mg/kg BW PO bid (Flecknell, 1987)
15 mg/kg BW SC bid (Flecknell, 1996)
Rabbit 15-20 mg/kg BW PO bid (Flecknell, 1987)
15 mg/kg BW SC bid (Flecknell, 1996)
Sheep 10 mg/kg BW SC sid (Flecknell, 1996)
Swine 10 mg/kg BW SC sid (Flecknell, 1996)

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Cephaloridine

Ferret 15 mg/kg BW IM sid (McKellar, 1989)
Gerbil 30 mg/kg BW IM bid (Flecknell, 1987)
Guineapig 10-25 mg/kg BW IM sid for 5-7 days (Harkness and Wagner, 1977)
15-25 mg/kg BW SC sid (Bauck, 1989)
12.5 mg/kg BW IM sid for 14 days (Dixon, 1986)
Hamster May cause enterocolitis (Bartlett et al., 1978)
10 mg/kg BW IM bid (Holmes, 1984)
30 mg/kg BW IM bid (Flecknell, 1987)
Mouse 30 mg/kg BW IM bid (Flecknell, 1987)
NHP 11 mg/kg BW IM bid (Melby and Altman, 1976)
20 mg/kg BW IM bid (Flecknell, 1987)
Rat 30 mg/kg BW IM bid (Flecknell, 1987)
Rabbit 10-25 mg/kg BW IM, SC sid for 5 days (Bowman and Lang, 1986)
Reptile 10 mg/kg BW IM, SC bid (Frye, 1981)

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Cephalothin

Bird 100 mg/kg BW IM qid (Burke, 1986)
100 mg/kg BW IM, IV, PO qid (Ritchie and Harrison, 1997)
Quail and ducks: 100 mg/kg BW IM, IV, PO q2-3h (Ritchie and Harrison, 1997)
Cat 40-80 mg/kg BW/day IM, IV q8-12h (Kinsell, 1986)
20-40 mg/kg BW IM, IV, SC tid (Hawkins, 1996)
15-35 mg/kg BW IM, IV, SC q6-8h (Boothe, 1996)
Dog 40-80 mg/kg BW/day IM, IV q8-12h (Kinsell, 1986)
20-40 mg/kg BW IM, IV, SC tid (Hawkins, 1996)
15-35 mg/kg BW IM, IV, SC q6-8h (Boothe, 1996)
Rabbit 13 mg/kg BW IM qid for 6 days (Bowman and Lang, 1986)
Reptile 20-40 mg/kg BW IM bid (Frye, 1981)

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Chloramphenicol palmitate (not for use in food animals)

Bird 30-50 mg/kg BW PO tid, qid (Ritchie and Harrison, 1997)
Cat 15-20 mg/lb BW PO q8-12h (Kinsell, 1986)
25-50 mg/kg BW PO bid (Carr, 1997)
50 mg/cat PO q4-6h (Booffie, 1996)
Chinchilla 30-50 mg/kg BW PO bid (Jenkins, 1992)
Dog 20-25 mg/lb BW PO q6-8h (Kinsell, 1986)
25-50 mg/kg BW PO tid (Carr, 1997)
50 mg/kg BW PO q4-6h (Boothe, 1996)
Ferret 40 mg/kg BW PO tid for 14 days (Kiueger et al., 1989)
50 mg/kg BW PO bid for 10 days (Kiueger et al., 1989)
Gerbil 50 mg/kg BW PO bid (Bauck, 1989)
Guineapig 50 mg/kg BW PO bid (Bauck, 1989)
50 mg/kg BW PO tid (Russell et al., 1981)
Hamster 20 mg/100 g BW PO tid (Russell et al., 1981)
50 mg/kg BW PO bid (Bauck, 1989)
Mouse 20 mg/100 g BW PO tid (oral suspension) (Russell et al., 1981)
100 mg/200 ml drinking water for 3-5 days (Williams, 1976)
50 mg/kg BW PO bid (Bauck, 1989)
NHP 50 mg/kg BW PO bid (Flecknell, 1987)
Rat 20 mg/100 g BW PO tid (Russell et al., 1981)
50 mg/kg BW PO bid (Bauck, 1989)
Rabbit 50 mg/kg BW PO sid for 5-7 days (Harkness and Wagner, 1983)
50 mg/kg BW PO bid (Bauck, 1989)
30-50 mg/kg BW PO bid for 5-7 days (Carpenter et al., 1995)
Reptile Tortoises: 20 mg/kg BW PO bid for 7-14 days (Page and Mautino, 1990)

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Chloramphenicol succinate (not for use in food animals)

Bird 80 mg/kg BW IM bid or tid (Burke, 1986)
80 mg/kg BW IM, IV, SC bid, tid (Ritchie and Harrison, 1997)
Cat 10 mg/kg BW IM, IV q12h (Kinsell, 1986)
50 mg/cat IM, IV, SC q4-6h (Boothe, 1996)
Dog 10 mg/kg BW IM, IV q12h (Kinsell, 1986)
50 mg/kg BW IM, IV, SC q4-6h (Boothe, 1996)
50 mg/kg BW SC sid (Flecknell, 1996)
Ferret 25 mg/kg BW SC sid (Flecknell, 1996)
30-50 mg/kg BW IM, IV bid (Johnson-Delaney, 1996)
Fish 75 mg/kg BW PO sid in feed for 14 days (CCAC, 1984)
Gerbil 30 mg/kg BW IM bid (Flecknell, 1987)
50 mg/60 ml drinking water for 2 weeks (Williams, 1976)
50 mg/kg BW SC bid (Bauck, 1989)
30 mg/kg BW SC bid (Flecknell, 1996)
Guineapig 20 mg/kg BW IM bid (Flecknell, 1987)
50 mg/kg BW SC bid (Bauck, 1989)
Hamster 30 mg/kg BM IM bid (Flecknell, 1987)
50 mg/kg BW SC bid (Bauck, 1989)
30 mg/kg BW SC bid (Flecknell, 1996)
Mouse 50 mg/kg BW IM bid (Flecknell, 1987)
50 mg/kg BW SC bid (Bauck, 1989)
NHP 25 mg/kg BW IV bid for 10 days (DaRif and Rush, 1983)
50 mg/kg BW IM bid for 10 days (DaRif and Rush, 1983)
110 mg/kg BW IM qid for 5-10 days for pneumococcal meningoencephalitis (Ialeggio, 1989)
20 mg/kg BW IM bid (Flecknell, 1996)
Rat 50 mg/kg BW IM bid (Flecknell, 1987)
50 mg/kg BW SC bid (Bauck, 1989)
10 mg/kg BW IM bid (Flecknell, 1996)
Rabbit 30 mg/kg BW IM sid for 5-7 days (Harkness and Wagner, 1983)
50 mg/kg BW SC bid (Bauck, 1989)
50 mg/kg BW SC, IM, IV tid (Russell et al., 1981)
30 mg/kg BW IM, IV tid for 5-7 days (Carpenter et al., 1995)
15 mg/kg BW IM bid (Flecknell, 1996)
Reptile Toads: 5 mg/100 g BW initially, then 3 mg/100 g BW PO bid for 5 days (Marcus, 1981)
Turtles: 40 mg/kg BW IM, IP bid for 7 days (Marcus, 1981)
Tortoises: 20 mg/kg BW IM bid for 7-14 days (Page and Mautino, 1990)
Swine 11 mg/kg BW IM sid (Flecknell, 1996)

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Copyright © 1999 Yale Animal Resources Center, Yale University
Last modified: February 17, 2000