Representative Publications - please click here for a comprehensive listing:

Wang, G., Seidman, M.M., and Glazer, P.M. 1996. Mutagenesis in mammalian cells induced by triple helix formation and transcription-coupled repair. Science, 271:802-805.

Reynolds, T.Y., Rockwell, S., and Glazer, P.M. 1996. Genetic instability induced by the tumor microenvironment. Cancer Res. 56:5754-5757.

Narayanan, L., Fritzell, J.A., Baker, S.M., Liskay, R.M. and Glazer, P.M. 1997. Elevated levels of mutation in multiple tissues of mice deficient in the DNA mismatch repair gene, PMS2. Proc. Natl. Acad. Sci. USA 94:3122-3127.

Chan, P.P., Lin, M., Faruqi, A.F., Powell, J., Seidman, M.M., and Glazer, P.M. 1999. Targeted correction of an episomal gene in mammalian cells by a short DNA fragment tethered to a triplex-forming oligonucleotide. J. Biol. Chem. 274:11541-11548.

Faruqi, A.F., Datta, H., Carroll, D., Seidman, M.M., and Glazer, P.M. 2000. Triple-helix formation induces recombination in mammalian cells via a nucleotide excision repair-dependent pathway. Mol. Cell. Biol. 20:990-1000.

Luo, Z., Macris, M.A., Faruqi, A.F., and Glazer, P.M. 2000. High-frequency intrachromosomal gene conversion induced by triplex-forming oligonucleotides microinjected into mouse cells. Proc. Natl. Acad. Sci. USA 97:9003-9008.

Vasquez, K.M., Narayanan, L. and Glazer, P.M. 2000. Specific mutations induced by triplex-forming oligonucleotides in mice. Science 290:530-533.

Yuan, J., Narayanan, L., Rockwell, S., and Glazer, P.M. 2000. Diminished DNA repair and elevated mutagenesis in mammalian cells exposed to hypoxia and low pH. Cancer Res. 60:4372-4376.

Peretz S., Jensen R., Baserga R. and Glazer P.M. 2001. ATM-dependent expression of the IGF-I receptor in a pathway regulating radiation response. Proc. Natl. Acad. Sci. USA 98:1676-1681.

Vasquez, K.M., Christensen, J., Li, L., Finch, R.A. and Glazer, P.M. 2002. Human XPA and RPA DNA repair proteins participate in specific recognition of triplex-induced helical distortions. Proc. Natl. Acad. Sci. USA 99:5848-5853.

Rogers, F.A., Vasquez, K.M., Egholm, M., and Glazer, P.M. 2002. Site-directed recombination via bifunctional PNA-DNA conjugates. Proc. Natl. Acad. Sci. USA 99:16695-16700.

Macris, M.A. and Glazer, P.M. 2003. Transcription dependence of chromosomal gene targeting by triplex-forming oligonucleotides. J. Biol. Chem. 278(5):3357-3362.

Mihaylova, V.T., Bindra, R., Yuan, J., Campisi, D., Narayanan, L., Jensen, R., Giordano, F., Johnson, R.S., Rockwell, S. and Glazer, P.M. 2003. Decreased expression of the DNA mismatch repair gene, Mlh1, under hypoxic stress in mammalian cells. Mol. Cell. Biol. 23(9):3265-3273.

Jensen, R. and Glazer, P.M. 2004. Cell-interdependent cisplatin killing by Ku/DNA-PK signaling transduced through gap junctions. Proc. Natl. Acad. Sci. USA 101:6134-6139.

Bindra, R.S., Schaffer, P.J., Meng, A., Woo, J., Maseide, K., Roth, M.E., Lizardi, P, Hedley, D.W., Bristow, R.G., and Glazer, P.M. 2004. Down-regulation of Rad51 and decreased homologous recombination in hypoxic cancer cells. Mol. Cell. Biol. 24(19): 8504-8518.

Knauert, M.P., Lloyd, J.A., Rogers, F.A., Datta, H.J., Bennett, M.L, Weeks, D.L. and Glazer, P.M. 2005. Distance and affinity dependence of triplex-induced recombination. Biochemistry 44(10): 3856-3864.

Kalish, J.M., Seidman, M.M., Weeks, D.L. and Glazer, P.M. 2005. Triplex-induced recombination and repair in the pyrimidine motif. Nucleic Acids Res. 33: 3492-3502.