Yanling Wu, M.D., Ph.D.
Associate Research Scientist, Department of Therapeutic Radiology
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yanling.wu@yale.edu Phone: 203.737.2787 Fax: 203.785.6309 Yale University School of Medicine Department of Therapeutic Radiology P.O. Box 208040 New Haven, Connecticut 06520-8040 |
Degrees/Education:
M.D., Nanjing University of Traditional Chinese Medicine, P.R.China, 1982
M.Sc., Okayama University, Department of Immunochemistry, Faculty of Pharmaceutical Sciences, 1994
Ph.D., Department of Medical Molecular Biochemistry, Okayama University Medical School, 1998
Faculty Appointments:
Attending Physician, Department of Internal Medicine, Suzhou 7th People’s Hospital, P.R. China (1982-1987)
Vice Chief of Medical Service, Suzhou 7th People’s Hospital, P.R.China (1987-1991)
Research Assistant, Okayama University, Faculty of Pharmaceutical Sciences, Japan (1991-1992)
Counselor of Oriental Medicine at Saiwa-cho Memorial Hospital, Japan (1994- 1998)
Postdoctoral Fellow, Department of Internal Medicine, The Univ. Michigan Medical School (1998-2000)
Postdoctoral Fellow, Department of Internal Medicine (Nephrology), Yale Univ. Sch. of Med.(2001-2006)
Associate Research Scientist, Department of Internal Medicine (Nephrology), Yale University School of Medicine (2006-2009)
Associate Research Scientist, Department of Therapeutic Radiology, Yale University School of Medicine (2009-present)
Certifications/Honors:
Special Award of Peace and Friendship in Japan (1996)
Sumitomo Social Welfare Fellowship, Japan (April 1997-March 1998)
International Communication Fellowship of Japan (April 1991-March 1992)
Kobayashi Medical Fellowship in Japan (April 1992-March 1994)
Research Interests:
Laboratory studies of DNA repair and gene targeting in human cells.
Bibliography:
1, Wu Y, Velazquez H, Xu J, Desir GV. Renalase deficiency contributes to hypertension and ischemic reperfusion damage. Nature Medicine (to be submitted)
2, Li G, Xu J, Wang P, Velazquez H, Li Y, Wu Y, Desir GV. Catecholamines regulate the
activity, secretion, and synthesis of renalase. Circulation. 2008,117(10):1277-82.
3, Bing-guan Chen, Yanling Wu, and Zhongmin Liu. Myoblast Therapy, From Bench to
Bedside. Cell Transplantation. 2006, 15:455-462.
4, Zhongmin Liu, Yanling Wu. Bing-guan Chen. Potent in vivo anti-tumor activity of isolated CD62Llow lymph node cells sensitized in vivo with tumor lysate-pulsed dendritic cell-based vaccines. Cytotherapy. 7(4):353-362,2005.
5, Xu, J., Li, G., Wang, P., Velazquez, H., Yao, X., Li, Y., Wu, Y, Peixoto, A., Crowley, S., Desir, GV. Renalase: a novel, soluble monoamine oxidase that regulates cardiac function and blood pressure. J Clin Invest. 2005, 115(5):1275-80.
6, Bing-guan Chen, Zhongmin Liu , Yanling Wu. Specific tolerance induction of allo-Kb skin grafts by FK506 in the CD8-depleted H-2k recipients required low amounts of Kb-antigen. Transplant Immunology. 2005, 15:9-16,2005.
7, Xu, J, Wang P, Li Y, Li G, Kaczmarek LK, Wu Y, Koni PA, Flavell RA, Desir GV. The voltage-gated potassium channel Kv1.3 regulates peripheral insulin sensitivity. Proc. Natl. Acad Sci USA. 101(9):3112-7, 2004.
8, Wu Y_Ling S, Zheng J, Linden J, Holoshitz J. Genoprotective pathways. II. Attenuation of
oxidative DNA damage by isopentenyl diphosphate. Mutation Research. 554(1-2):33-43, 2004.
9, Wu Y, Zheng J, Linden J, Holoshitz J. Genoprotective pathways. Part I. Extracellular
signaling through G(s) protein-coupled adenosine receptors prevents oxidative DNA damage.
Mutation Research. 546(1-2):93-102, 2004.
10, Jianchao Xu, Pandelakis A. Koni, Peili Wang, Guoyong Li, Leonard Kaczmarek, Yanling Wu, Yanyan Li, Richard A. Flavell and Gary V. Desir. The voltage-gated potassium channel Kv1.3 regulates energy homeostasis and body weight. Human Molecular Genetics. 12(5): 1-9, 2003.
11, Shulan Tian, Weimin Liu, Yanling Wu, Hamid Rafi, Alan S. Segal and Gary V. Desir.
Regulation of the voltage-gated K channel KCNA10 by KCNA4B, a novel b subunit. Am J
Physiol Renal Physiol. 283:F1-8, 2002.
12, Livant DL. Brabec RK. Kurachi K. Allen DL. Wu Y. Haaseth R. Andrews P. Ethier SP.
Markwart S. The PHSRN sequence induces extracellular matrix invasion and accelerates wound healing in obese diabetic mice. J Clin Invest. 105(11):1537-45, 2000.
13, Oka, Y, Y-L. Wu, Miyazaki, M. Therapeutic effect of Coix Seed Extract drug on
hydrarthrosis in patients under hemodialysis. Japanese Journal of Oriental Medicine.
1999, 49(5):817-822.
14, Oka, Y, Y-L. Wu, M. Miyazaki. Effect of combined therapy with steroid and Sairei-to on long-term control of arthralgia in dialysis arthropathy. Dialysis 1998, 31(7):1067-1071.
15, Wu, Y-L, H. Sumiyoshi, Khaleduzzaman M, Y. Ninomiya, H. Yoshioka. cDNA sequence and expression of the mouse !1(V) collagen gene (Col5!1). Biochimica Biophysica Acta 1998.
16, Wu, Y-L, E. Gohda, M. Iwao, T. Matsunage, T. Nagao, T Takebe, I Yamamoto. Stimulation of hepatocyte growth factor production by ascorbic acid and its stable 2-glucoside. Growth Regulation 1997, 7(2):1-10.
17, Oka, Y., Y-L. Wu, N. Matsunaga, N. Takatsu, M. Miyazaki, K Gokume. Effects of combined therapy with prednison and Sai-rei-to on dialysis arthropathy. Chugoku Journal of Renal Failure. 1994, 3:114-115.
18, Matsunaga T, Gohda E, Takebe T, Wu Y-L, Iwao M, Kataoka H, Yamamoto. Expression of hepatocyte growth factor is up-regulated through activation of cAMPmediated pathway. Exp Cell Res. 1994, 210:326-335.
Abstracts ( Symposium)
1, Wu, Y-L et al. The mechanism of interleukin-mediated production of hepatocyte growth factor (HGF). 113th Annual meeting of Association of Japanese Pharmacology. March 1993; page 74.
2, Wu, Y-L et al. The effect of IL-1 and TNF! on PMA-induced production of hepatocyte growth factor (HGF). 66th annual meeting of Association of Japanese Biochemistry. 1993; 65(8)835 (No.2677).
3, Wu, Y-L et al. The primary structure of murine type V collagen !1 chain and its gene expression. Preceeding in 37th symposium of association of Japanese Biochemistry in Hiroshima. March 1996, page 29, No.26.
