Susan Baserga, MD, PhD
Associate Professor, Department of Molecular Biophysics & Biochemistry,
Genetics and Therapeutic Radiology
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susan.baserga@yale.edu Phone: 203.785.4618 Appt Phone: Fax: 203.785.6404 Dept. of Molecular Biophysics & Biochemistry C114 SHM Yale University 333 Cedar Street P.O. Box 208024 New Haven, CT 06520-8024 |
Degrees/Education :
B.S. Yale College 1980
M. Phil. Yale University 1984; M.D.,
Ph.D. Yale University 1988
Faculty Appointments :
Assistant Professor, Yale University School of Medicine, Department of Therapeutic Radiology and Genetics, (1993-99)
Associate Professor (term), Yale University School of Medicine, Department of Therapeutic Radiology and Genetics, (1999-2002)
Associate Professor (tenure), Yale University, Department Molecular Biophysics and Biochemistry, Genetics and Therapeutic Radiology (2002-present)
Research Interests:
Ribosome biogenesis is a complex process requiring the coordination of expression of rRNA and protein moieties and their assembly in the eukaryotic nucleolus, and we are striving to understand it by comparative genomics/RNA biology in a variety of model organisms. The nascent pre-rRNA transcript is both cleaved and modified prior to assembly. Using the yeast S. cerevisiae, my laboratory is studying the role of the ribonucleoprotein and protein complexes in the cleavage reactions that generate the mature rRNAs. Using modern proteomics techniques, we have recently identified the protein components of a large, nucleolar ribonucleoprotein that contains the U3 snoRNA and 40 other proteins, which we have called the SSU processome. Functional studies on this complex and related nucleolar RNA processing complexes will constitute the new directions of our laboratory.
