Bauer E. Sumpio, MD, PhD

Professor and Vice-Chairman of Surgery
Chief, Section of Vascular Surgery
Education: BA/MA, Johns Hopkins University
MD/PhD, Cornell University Medical College


Academic and professional honors:

Professional associations:

Selected publications:
Powell R J;Carruth J A;Basson M D;Bloodgood R;Sumpio B E. Matrix-specific effect of endothelial control of smooth muscle cell migration. Journal of Vascular Surgery. 24: 51-7, 1996.

Yano Y;Saito Y;Narumiya S;Sumpio B E. Involvement of rho p21 in cyclic strain-induced tyrosine phosphorylation of focal adhesion kinase pp125fak, morphological changes and migration of endothelial cells. Biochemical and Biophysical Research Communications. 224: 508-15, 1996.

Yano Y;Geibel J;Sumpio B E. Tyrosine phosphorylation of pp125fak and paxillin in aortic endothelial cells induced by mechanical strain. American Journal of Physiology. 271: c635-49, 1996.

Oluwole B O;Mcmillen M;Sumpio B E. Endothelial cell control of vasomotor tone. Annals of Vascular Surgery. 9: 293-301, 1995.

Awolesi M A;Sessa W C;Sumpio B E. Cyclic strain upregulates nitric oxide synthase in cultured bovine aortic endothelial cells. Journal of Clinical Investigation. 96: 1449-54, 1995.

Du W;Mills I;Sumpio B E. Cyclic strain causes heterogeneous induction of transcription factors, ap-1, cre binding protein and nf-kb, in endothelial cells: species and vascular bed diversity. Journal of Biomechanics. 28: 1485-91, 1995.

Gollin G;Ward B;Meier G H;Sumpio B E;Gusberg R J. Central splanchnic venous thrombosis often unsuspected, usually uncomplicated. Journal of Clinical Gastroenterology. 18: 109-13, 1994.

Sumpio B E;Li G;Deckelbaum L I;Gasparro F P. Inhibition of smooth muscle cell proliferation by visible light-activated psoralen. Circulation Research. 75: 208-13, 1994.

Mills I;Murata K;Packer C S;Sumpio B E. Cyclic strain stimulates dephosphorylation of the 20kda regulatory myosin light chain in vascular smooth muscle cells published erratum appears in biochem biophys res commun 1995 feb 27;2073:1058. Biochemical and Biophysical Research Communications. 205: 79-84, 1994.

Sumpio B E;Widmann M D;Ricotta J;Awolesi M A;Watase M. Increased ambient pressure stimulates proliferation and morphologic changes in cultured endothelial cells. Journal of Cellular Physiology. 158: 133-9, 1994.

Deckelbaum L I;Scott J J;Stetz M L;O'brien K M;Sumpio B E;Madri J A;Bell L. Photoinhibition of smooth muscle cell migration: potential therapy for restenosis. Lasers In Surgery and Medicine. 13: 4-11, 1993.

Brophy C M;Mills I;Rosales O;Isales C;Sumpio B E. Phospholipase c: a putative mechanotransducer for endothelial cell response to acute hemodynamic changes. Biochemical and Biophysical Research Communications. 190: 576-81, 1993.

Sumpio B E;Phan S M;Gasparro F P;Deckelbaum L I. Control of smooth muscle cell proliferation by psoralen photochemotherapy. Journal of Vascular Surgery. 17: 1010-6; discussion 1, 1993.

Rosales O R;Sumpio B E. Changes in cyclic strain increase inositol trisphosphate and diacylglycerol in endothelial cells. American Journal of Physiology. 262: c956-62, 1992.

Rosales O R;Isales C;Nathanson M;Sumpio B E. Immunocytochemical expression and localization of protein kinase c in bovine aortic endothelial cells. Biochemical and Biophysical Research Communications. 189: 40-6, 1992.

Iba T;Mills I;Sumpio B E. Intracellular cyclic amp levels in endothelial cells subjected to cyclic strain in vitro. Journal of Surgical Research. 52: 625-30, 1992.

Rosales O R;Sumpio B E. Protein kinase c is a mediator of the adaptation of vascular endothelial cells to cyclic strain in vitro. Surgery. 112: 459-66, 1992.

Iba T;Sumpio B E. Tissue plasminogen activator expression in endothelial cells exposed to cyclic strain in vitro. Cell Transplantation. 1: 43-50, 1992.

Sumpio B E. Hemodynamic forces and the biology of the endothelium: signal transduction pathways in endothelial cells subjected to physical forces in vitro. Journal of Vascular Surgery. 13: 744-6, 1991.

Iba T;Shin T;Sonoda T;Rosales O;Sumpio B E. Stimulation of endothelial secretion of tissue-type plasminogen activator by repetitive stretch. Journal of Surgical Research. 50: 457-60, 1991.

Iba T;Maitz S;Furbert T;Rosales O;Widmann M D;Spillane B;Shin T;Sonoda T;Sumpio B E. Effect of cyclic stretch on endothelial cells from different vascular beds. Circulatory Shock. 35: 193-8, 1991.

Iba T;Sumpio B E. Morphological response of human endothelial cells subjected to cyclic strain in vitro. Microvascular Research. 42: 245-54, 1991.

Sumpio B E;Phan S. Nephrotoxic potential of fk 506. Transplantation Proceedings. 23: 2789-90, 1991.

Sumpio B E;Banes A J;Link G W;Iba T. Modulation of endothelial cell phenotype by cyclic stretch: inhibition of collagen production. Journal of Surgical Research. 48: 415-20, 1990.

Sumpio B E;Widmann M D. Enhanced production of endothelium-derived contracting factor by endothelial cells subjected to pulsatile stretch. Surgery. 108: 277-81; discussion 2, 1990.

Letsou G V;Rosales O;Maitz S;Vogt A;Sumpio B E. Stimulation of adenylate cyclase activity in cultured endothelial cells subjected to cyclic stretch. Journal of Cardiovascular Surgery. 31: 634-9, 1990.

Awolesi MA, Sessa WC, Sumpio BE. Cyclic strain upregulates nitric oxide synthase in cultured bovine aortic EC. J Clin Invest 96:1449, 19.

Sumpio BE, (editor) Hemodynamic Forces and Vascular Cell Biology (1993), RG Landes Publishers, Austin, TX.



interests:
(besides keeping busy, Dr. Sumpio also enjoys:)

  • keeping even more busy
  • tennis
  • driving fast cars
  • eating Mexican food


fmb 137
333 cedar street
new haven, ct 06510
 office: 203.785.2561
fax: 203.785.7609
email: bauer.sumpio@yale.edu