CURRICULUM VITAE

Bauer E. Sumpio, M.D., Ph.D.

Professor & Vice-Chairman of Surgery

Date of Birth: January 17, 1956

Place of Birth: New York, New York

Marital Status: Married, 3 children

Business Address:
                                Department of Surgery
                                Yale University School of Medicine
                                333 Cedar Street, FMB 137
                                New Haven, CT 06510
                                (203) 785-2561

Present Departmental Appointments:

Chief, Section of Vascular Surgery

Vice-Chairman of Surgery for Affiliated Programs

Program Director, Vascular Surgery

Associate Program Director, General Surgery Residency

Present Institutional Appointment:

Professor of Surgery (Tenured 1994)

Present Hospital Appointments:

Attending Surgeon Yale-New Haven Hospital

Staff Surgeon West Haven VA Medical Center

Courtesy Attending Staff Bridgeport Hospital

Institutional Appointments: Yale University School of Medicine
 

Hospital Appointments:
 

Institutional Appointments:
 

Departmental Appointments:
 

Certification:
 

Licensure
 

Education and Postgraduate Activity:
 

Awards and Honors:
 

Patents Awarded:

Patent # 5,354,774 (awarded 10/11/94) and Patent # 5,514,707 (awarded 5/7/96) "Inhibition of smooth muscle cell proliferation by 8-methoxypsoralen photoactivated by visible light."
 
 

Research Projects and Grants:

Present

1. NIH R01 HL 47345-04 (P.I., Funding period: 4/01/96-3/31/99, $461,694) "Mechanisms by which EC sense changes in hemodynamics"

2. VA Merit Review (P.I., Funding Period 10/98-9/03, $627,234) "Mechanical Stretch of Vascular Cells". This is a competitive renewal of #3, which has just been awarded.

3. VA Merit Review (P.I., Funding Period 10/94-9/98, $429,384) "Regulation of growth factor production by stretched endothelial cells".

Previous

1. American Heart Association (National Affiliate) (P.I., Funding Period 7/94-6/97, $120,000) "Characterization of cyclic strain promoter elements"

2. Merck Grant (P.I., Funding period: 12/88-12/94, $60,000) "FK-506 toxicity in the kidney"

3. Illumenex Grant (P.I., Funding Period: 2/93-6/94, $120,000) "Psoralen phototherapy for treatment of restenosis)

4. NIH R01 HL 47345-01 (P.I., Funding period: 12/01/91-11/30/94, $495,000) "Mechanisms by which EC sense changes in hemodynamics"

5. NIH R29 HL 40305 (P.I., Funding period: 04/88-03/93, $350,000) "Effect of mechanical stress on vascular cells in culture"

6. VA Merit Review (P.I., Funding period: 10/01/91-9/30/94, $278,013) "Role of pulsatility in para-anastamotic hyperplasia: an in vitro model"

7. Whitaker Foundation (P.I., Funding period: 3/89-2/92, $180,000) "Mechanical deformation of endothelial cells grown on different biomaterials and surfaces."

8. American Heart Association, Connecticut Affiliate (P.I., Funding Period: 7/89-6/91, $ 63,000) "Growth of endothelial cells and smooth muscle cells in a pulsatile environment"

9. VA Research Advisory Group 001 (P.I., Funding period: 10/88-9/90, $58,000) "Repetitive mechanical stretching of vascular cells in culture"

10. Biomedical Research Support Grant RR0358 (P.I., Funding period: 1/26/88-1/25/89, $8,500) "The effects of rheology on organ function"

Pending

1. NIH R01 HL 49906 (P.I., Funding period: 7/94-6/97, $409,000) "Modulation of EC phenotype by ambient pressure"

By Members of the laboratory

1. Council for Tobacco Research (P.I. Wei Du, M.D., 1994-1997, $150,000)

"Characterization of cyclic strain promoter elements in endothelial cells"

2. American Heart Association, (CT Affiliate) (P.I. Ira Mills, Ph.D., 1992-1994,

$80,000)"Mechanical Signalling in Vascular Endothelial Cells"

3. NASA RFA (P.I. Ira Mills, Funding period: 10/95-9/98, $266,635) "Are G-proteins mechanosensors for endothelial cells?"

By Trainees in the laboratory

1. NIH NRSA 1 F32 HL08674 (1993-1995)

"PKC Activity in EC Subjected to Cyclic Stretch"

    Leigh V. Evans, M.D.

2. NIH NRSA 1 F32 HL08675 (1992-1994)

"EDRF production by EC subjected to cyclic strain"

    Mark Awolesi, M.D.

3. NIH NRSA IF32HL 08245-01 (1991-1993)

"Modulation of SMC contractility by cyclic stretch of EC"

    Mark D. Widmann, M.D.

4. International Society for Cardiovascular Surgery, Student Research Fellowship

(1991-92) "Activation of protein kinase C in endothelial cells by cyclic stretch"

    Tae Shin, YMS III ('93)

5. American Heart Association, CT Affiliate, Fellowship (1990-91)

"Signal Transduction of Cyclic Stretch to Endothelial Cells"

    Oscar Rosales, M.D.

6. International Society for Cardiovascular Surgery, Student Research Fellowship (1990-91) "Production of PDGF by Vascular Cells Subjected to Cyclic Strain"

    Robert Spillane, YMS III ('91)

7. International Society for Cardiovascular Surgery, Student Research Fellowship

(1993-94) "Modulation of endothelial cell phenotype by ambient pressure"

    Joseph Ricotta

8. International Society for Cardiovascular Surgery, Student Research Fellowship

(1994-95) "Diacylglycerol formation in vascular endothelial cells"

    Lyubov Frenkel

9. International Society for Cardiovascular Surgery, Student Research Fellowship

(1994-95) "Photochemotherapy with 8-methoxypsoralen"

    David Lee, YMS II ('96)

Fellows, Residents and Medical Students Trained:
 

Committee Membership

Yale University School of Medicine:
 

Yale-New Haven Hospital:
 

West Haven VA Medical Center:
 

Society membership:
 

Society Committees:

Program Committee- Association of Academic Surgeons (1990-92)
Program Committee- New England Society for Vascular Surgery (1992-1995)
Program Committee- Society of Univers ity Surgeons (1993-1995)
Program Committee- Peripheral Vascular Surgery Society (1993-1996)
Arterial Wall Biology Committee- Association of Program Directors in General Vascular Surgery (1994)
Committee on Fundamental Problems in Surgery-American College of Surgeons (1994-2000)
Advisory Council for Vascular Surgery-American College of Surgeons (1994-2000)
Program Chairman, CT Chapter, American College of Surgeons and Connecticut Society of American Board of Surgery (1996-1998)
President Elect, Connecticut Society of American Board of Surgery (1997)
Membership Committee- New England Society for Vascular Surgery (1998-2003)
President, Connecticut Chapter, American College of Surgeons (1999)

Study Section:

Member Surgery and Bioengineering Study Section, National Institutes of Health (July 1,1993 - June 30, 1997)
Member Surgery Study Section, Veterans Administration (October 1, 1991-June 30, 1995)
Chairman Surgery Study Section, Veterans Administration (October 1, 1994-June 30, 1995)
Ad Hoc Review Committee - National Institute of Health Surgery and Bioengineering Study Section (June 1990, Feb 1992)
Special Reviewer - Center for Disease Control Injury Research Study Section (May 1990)
Reviewer- NIH Special Study Section-B2 (July 1991)

Editorial Boards

Journal of Vascular Surgery- Member
Jounal of American College of Surgeons - Member
Cell Transplantation - Member
Journal Surgical Research - Member
American Journal of Physiology - Special Reviewer

BIBLIOGRAPHY

Ph.D. Thesis:

Tubular Absorption and Catabolism of Low Molecular Weight Proteins. Cornell University Medical College, New York, New York, 1981.

Manuscripts:

1. Sumpio BE, Maack T. Kinetics, Competition, and Selectivity of Tubular Absorption of Proteins. Am J Physiol 243(12):F379-392, 1982.

2. Sumpio BE, Chaudry IH, Baue AE. Enhanced functional recovery of isolated perfused rat kidneys subjected to warm ischemia after treatment with ATP-MgCl₂. Circ Shock 10(3):278, 1983.

3. Sumpio BE, Chaudry IH, Clemens MG, Baue AE. Amelioration of gentamicin nephrotoxicity by ATP-MgCl₂ treatment. Circ Shock 31:68-69, 1984.

4. Sumpio BE, Ernstoff M, Kirkwood J. Urinary excretion of interferon, beta-2 microglobulin and albumin during interferon therapy. Cancer Res 44(8):3599-3607, 1984.

5. Sumpio BE, Camargo MG, Maack T. Kinetics of renal catabolism of absorbed proteins: influence of lysosomal pH. Contributions to Nephrology 42:795-821, 1984.

6. Sumpio BE, Chaudry IH, Baue AE. Nuclear magnetic resonance study showing the reperfusion injury following ischemia and its improvement with ATP-MgCl₂ treatment. Surg Forum 35:17-19, 1984.

7. Sumpio BE, Chaudry IH, Clemens MG, Baue AE. Accelerated recovery of isolated rat kidney with ATP-MgCl₂ after warm ischemia. Am J Physiol 247:R1047-R1053, 1984.

8. Camargo MJF, Sumpio BE, Maack T. Renal hydrolysis of absorbed protein: influence of load and lysosomal pH. Am J Physiol 247:F656-664, 1984.

9. Sumpio BE, Chaudry IH, Baue AE. ATP-MgCl₂ ameliorates the reperfusion injury following ischemia as determined by ³¹P-NMR. Arch Surg 120(2):165-169, 1985.

10. Sumpio BE, Chaudry IH, Baue AE. Reduction of the drug-induced nephrotoxicity by ATP-MgCl₂. I. Effects on the cis-diaminedi- chloroplatinum-treated isolated perfused kidneys. J Surg Res 38(5):429-437, 1985.

11. Sumpio BE, Chaudry IH, Baue AE. Reduction of the drug-induced nephrotoxicity by ATP-MgCl₂. II. Effects on gentamicin- treated isolated perfused kidneys. J Surg Res 38(5):429-437, 1985.

12. Sumpio BE, Traquina DN, Gusberg RH. Comparison of the results of surgery in occlusive vs. aneurysmal disease of the abdominal aorta. Arch Surg 120(7):817-819, 1985.

13. Sumpio BE, Hayslett JP. Renal handling of proteins during health and disease states. Quart J Med, New Series 57, 222:611-635, 1985.

14. Sumpio BE, Chaudry IH, Baue AE. Alleviation of the cyclosporine induced nephrotoxicity with ATP-MgCl₂ and Verapamil. Surg Forum 36:336-338, 1985.

15. Sumpio BE, Hull MJ, Baue AE, Clemens MG, Chaudry IH. Comparison of effects of ATP-MgCl₂ and Adenosine-MgCl₂ on renal function following ischemia. Circ Shock 18:375-376, 1986.

16. Sumpio BE, Hull MJ, Baue AE, Chaudry IH. Effects of ATP-MgCl₂ and adenosine-MgCl₂ administration on intracellular ATP levels in the kidney. Biochem Biophys Acta 862(2):303-308, 1986.

17. Sumpio BE, Dwyer JM, Flye MW. T-lymphocyte subsets in renal allograft recipients undergoing different immunosuppression protocols. Curr Surg 43(6):502-503, 1986.

18. Sumpio BE, Hull MJ, Chaudry IH, Stephan RN, Baue AE. Verapamil and ATP-MgCl₂ prevents cyclosporine-induced nephrotoxicity by improving mitochondrial and tissue Ca²⁺/Mg²⁺ ratios. Surg Forum 37:349-351, 1986.

19. Morse SS, Strauss EB, Sumpio BE. Apparent arterial occlusion due pneumatic antishock garment: pitfall in trauma angiography. AJR 147:391-392, 1986.

20. Sumpio BE, Ballantyne GH, Zdon M, Modlin IM. Acute appendicitis in the elderly: an unusual presentation of colon cancer. Dis Colon Rectum 29:668-670, 1986.

21. Sumpio BE, Bhatt S, May CJ. Lumbar actinomycosis: an unusual presentation of primary actinomycotic empyema. Infections in Surgery 6(3)148-155, 1987.

22. Sumpio BE, Baue AE, Chaudry IH. Treatment with Verapamil and ATP-MgCl₂ reduces cyclosporine nephrotoxicity. Surgery 101:315-322, 1987.

23. Sumpio BE, Hull MJ, Baue AE, Chaudry IH. Effect of ATP-MgCl₂ and adenosine-MgCl₂ on function of ischemic kidneys. Am J Physiol 252:R388-R393, 1987.

24. Sumpio BE, Dwyer JM, Flye MW. T-lymphocyte subsets in cyclosporine - and azathiaprine - treated renal allograft recipients. Annals of Surgery 205(1):49-53, 1987.

25. Sumpio BE, Jennings T, Marino M, Sullivan P. Adenoid cystic carcinoma of the breast: data from the Connecticut Tumor Registry and a Review of the Literature. Annals of Surgery 205(3):295-301, 1987.

26. Sumpio BE, Upchurch GR, Kaiser D, Adkinson JT, Palladino GW, Johnson G. Effect of viscosity and oncotic pressure on the function of isolated perfused rat kidneys. Circ Shock 21:360, 1987.

27. Sumpio BE, Gusberg RJ. Neurologic deficit following blunt abdominal aortic trauma. JVasc Surg 6:412-414,1987.

28. Sumpio BE, Baue AE, Chaudry IH. Alleviation of cyclosporine and nephrotoxicity with Verapamil and ATP-MgCl₂: mitochondrial respiratory and calcium studies. Annals of Surgery 206: 655-660, 1987.

29. Sumpio BE, Banes AJ, Letton RL, Levin LG, Johnson G. Mechanical stress stimulates aortic endothelial cells to proliferate. J Vasc Surg 6:252-256,1987.

30. Sumpio BE, Banes AJ, Buckley M, Johnson G. Alterations in aortic endothelial cell morphology and cytoskeletal protein synthesis during cyclic tensional deformation. J Vasc Surg 7: 130-138, 1988.

31. Sumpio BE, O'Leary G, Gusberg RJ. Variceal bleeding, hypersplenism and systemic mastocystosis: pathology and management. Arch Surg 123: 767-769, 1988.

32. Sumpio BE, Banes AJ. Response of cultured aortic smooth muscle cells to pulsatile stretching. J. Surg. Res. 44: 696-701, 1988.

33. Sumpio BE. Cyclosporine toxicity in the isolated perfused rat kidney. Transplantation Proc 20(3) Suppl 3: 712-716, 1988.

34. Sumpio BE, Banes AJ, Johnson G. Prostacyclin synthetic activity in cultured endothelial cells undergoing cyclic mechanical deformation. Surgery 104:383-389, 1988.

35. Sumpio BE, Banes AJ, Johnson G. Enhanced collagen production by smooth muscle cells during mechanical stretching. Arch Surg : 123: 1233-1236, 1988.

36. Buckley MJ, Banes AJ, Levin LG, Sumpio BE. Osteoblasts increase their rate of division and align in response to cyclic, mechanical tension in vitro. J Bone Mineral 4: 225-236, 1988.

37. Sumpio BE, Upchurch GR, Johnson G. The influence of perfusate viscosity, RBC deformability and drag on the function of an isolated perfused rat kidney. J. Surg. Res. 46:4-8, 1989.

38. Sumpio BE. Mechanical stress and cell growth. J. Vasc. Surg. 10: 570-571, 1989.

39. Sumpio BE, Kupper TS. Interleukin-6 production by vascular smooth muscle cells: etiology of SMC quiescence in vivo. Surg. Forum. 45: 323-325, 1989.

40. Sumpio BE, Banes AJ, Link GW, Iba T. Modulation of endothelial cell phenotype by cyclic stretch: inhibition of collagen production. J. Surg. Res. 48:415-420, 1990.

41. Meier GH, Sumpio BE, Black HR, Gusberg RJ. Captopril Renal Scintigraphy-An advance in the detection and treatment of renovascular hypertension. J. Vasc. Surg. 11:770-777, 1990.

42. Sumpio BE, Widmann MD. Enhanced production of an endothelium-derived contracting factor by endothelial cells subjected to pulsatile stretch. Surgery 108: 277-282, 1990.

43. Letsou GV, Rosales O, Maitz S, Vogt A, Sumpio BE. Stimulation of adenylate cyclase activity in cultured endothelial cells subjected to cyclic stretch. J. Cardiovasc. Surg. 31(5):634-639, 1990.

44. Mills I, Letsou G, Rabban J, Sumpio BE, Gewirtz H. Mechanosensitive adenylate cyclase activity in coronary vascular smooth muscle cells. Bioch. Biophys. Res. Comm. 171(1):143-147,1990.

45. Garrand TJ, Stetz ML, O'Brien KM, Gindi GR, Sumpio BE, Decklebaum LI. Design and evaluation of a fiberoptic fluoresence guidance laser recanalization system. Lasers in Surg. Med. 11:106-116, 1991.

46. Sumpio BE. Hemodynamic Forces and the Biology of the Endothelium: Signal Transduction Pathways in Endothelial Cells Subjected to Physical Forces In Vitro. J. Vasc. Surg. 13: 744-746, 1991.

47. Iba T, Shin T, Sonoda T, Rosales O, Sumpio BE. Stimulation of endothelial secretion of tissue type plasminogen activator by repetitive stretch. J. Surg. Res. 50: 457-460, 1991.

48. Sumpio, B.E., Phan S. Nephrotoxic potential of FK 506. Transplant. Proc. 23(6): 2801-2802, 1991.

49. Brophy CM, Sumpio BE, Reilly JM, Tilson MD. Electrophoretic characterization of protease activity in aneurysmal aorta: Report of a unique 80 kDa elastolytic activity. Surg. Res. Commun. 10: 315-321, 1991.

50. Iba T, Sumpio BE. Morphologic evaluation of human endothelial cells subjected to repetitive stretch in vitro. Microvasc. Res. 42: 245-254, 1991.

51. Iba T, Maitz S, Furbert T, Rosales O, Widmann M, Spillane R, Shin T, Sonoda T, Sumpio BE. Effect of cyclic stretch on endothelial cells from different vascular beds. Circ. Shock 35: 193-198, 1991.

52. Rodriguez R, Stepke M, Maitz S, Cuono CB, Sumpio BE. Amelioration of renal ischemia by phosphocreatine. J. Surg. Res. 51(4): 271-274, 1991.

53. Sumpio BE. What's new in vascular surgery. Current Surg 48(7) 479-481, 1991.

54. Widmann MD, Sumpio BE. Persistent Hypoglossal Artery: An Anomaly Leading To a False Positive Carotid Duplex. Annals Vasc. Surg. 6: 176-178, 1992.

55. Iba T, Sumpio BE. Tissue plasminogen activator expression in endothelial cells exposed to cyclic strain in vitro. Cell Transplant. 1:43-50, 1992.

56. Rosales OR, Sumpio BE. Changes in cyclic strain increase inositol trisphosphate and diacylglycerol in endothelial cells. Am. J. Physiol. 262: C956-C962, 1992.

57. Sumpio BE. Molecular Biology of the Vascular System: Fundamental concepts and the tools. J. Vasc. Surg. 15: 906-907, 1992.

58. Rosales O, Sumpio BE. Protein kinase C is a mediator of the adaptation of vascular endothelial cells to cyclic strain in vitro. Surgery 112:459-466,1992.

59. Iba T, Mills I, Sumpio BE. Intracellular cyclic AMP levels in endothelial cells subjected to cyclic strain in vitro. J. Surg. Res. 52:625-630, 1992.

60. Widmann MD, Letsou GV, Baldwin J, Sumpio BE. Cardiac endothelial cells subjected to cyclic strain. J. Surg. Res. 53: 331-334, 1992.

61. Rosales OR, Isales C, Nathanson M, Sumpio BE. Immunocytochemical expression and localization of protein kinase C in bovine aortic endothelial cells Bioch. Biophys. Res. Comm. 189:40-46, 1992.

62. Cohen CR, Mills I, Sumpio BE. Are G-proteins mechanotransducers for endothelial cells? Surg. Forum 48: 300-302, 1992.

63. Deckelbaum LI, Scott JJ, Steitz ML, O'Brien KM, Sumpio BE, Madri JA, Bell L. Photoinhibition of smooth muscle cell Migration: Potential Therapy for Restenosis. Lasers in Surg Med 13: 4-11, 1993.

64. Brophy C, Mills, I, Rosales O, Isales C, Sumpio BE. Phospholipase C: An important mechanotransduction pathway for endothelial cells. Bioch. Biophys. Res. Comm. 190: 576-581, 1993.

65. Meier GH, Sumpio BE, Setaro J, Black H, Gusberg RJ. Captopril Renal Scintigraphy: A new standard for predicting outcome after renal revascularization. J. Vasc. Surg. 17: 280-287, 1993.

66. Gasparro FP, Gattolin P, Deckelbaum LI, Sumpio BE. The excitation of 8-Methoxypsoralen with Visible Light. Quantitation of Monoadducts and Crosslinks by Reversed Phase HPLC. Photochem. Photobiol. 57:1007-1010, 1993.

67. Sumpio BE, Gasparro FP, Deckelbaum LI. Photochemotherapy with UV light inhibits SMC proliferation in culture. J Vasc Surg 17:1010-1018, 1993.

68. McMillen MA, Huribal M, Kumar R, Sumpio BE. Endothelin-stimulated human monocytes produce Prostaglandin E₂ but not leukotriene B₄. J. Surg. Res. 54:331-335, 1993.

69. Brophy CM, Evans L, Sumpio BE. Defacation syncope secondary to functional inverior vena caval obstruction during a Valsalva maneuver. Ann. Vasc. Surg. 7:374-377, 1993.

70. Widmann MD, Sumpio BE. Lipoprotein (a): A Risk Factor for Peripheral Vascular Disease. Ann Vasc Surg 7: 446-451, 1993.

71. Li G, Wang Z, Wu J, Du W, Pu L, Chang H, Wang D, Sumpio B.E. Enhanced Patency of Venous Dacron Graft by Endothelial Cell Sodding. Ann Vasc Surg. 7: 429-436, 1993.

72. McMillen MA, Huribal M., Sumpio BE. A Common pathway of endothelial-leukocyte interaction in shock, ischemia and reperfusion. Am. J. Surgery 166:563-567, 1993.

73. Sumpio BE, Huribal M. Stroke and TIAs: Role of carotid and aortic surgery. Choices in Cardiology 7(10):348-353, 1993.

74. Gollin G, Ward B, Meier GH, Sumpio BE, Gusberg RJ. Central Splanchnic Venous Thrombosis: Often Unsuspected, Usually Uncomplicated. J Clin Gastro 18(2):109-113,1994.

75. Wiersbitzky M, Mills I, Sumpio BE, Gewirtz H. Chronic Cyclic Strain Reduces Adenylate Cyclase Activity and Stimulatory G Protein Subunit Levels in Coronary Smooth Muscle Cells. Exp. Cell Res. 210: 52-55, 1994.

76. Sumpio BE, Widmann MD, Awolesi MA, Ricotta J, Watase M. Increased Ambient pressure Stimulates Proliferation and Morphologic Changes in Cultured Endothelial Cells. J. Cell Physiol. 158: 133-139, 1994.

77. Huribal M, Kumar R, Ortmeyer JE, Sumpio BE, McMillen MA. Endothelin stimulated monocyte supernatants enhance neutrophil superoxide production. Shock 1:184-187, 1994.

78. Sumpio BE, Du W, Cohen CR, Evans L, Isales C, Rosales OR, Mills. Signal transduction pathways in vascular cells exposed to cyclic strain. Society for Experimental Biology Seminar Series: Biomechanics and Cells 54:3-22, 1994.

79. Sumpio BE. The pathogenesis of atherosclerosis. J. Cardiovasc. Diag. Proc. 11: 257-259, 1994.

80. Sumpio BE, Du W, Xu W. Exposure of endothelial cells to cyclic strain induces c-fos, fosB and c-jun but not junB or junD and increases the transcription factor AP-1. Endothelium 22:149-156, 1994.

81. Bennett DR, Huribal M, Sumpio BE, McMillen MA, Nelson PK. Management of
traumatic vertebral pseudoaneurysm and arterio-venous fistula. Vasc. Forum 2:250-255,1994.

82. Sumpio BE, Gasparro FP, Deckelbaum LI. Visible light activation of psoralen leads to reversible smooth muscle cell static growth. Circ. Res 75: 208-213, 1994.

83. Gallagher GL, Du W, Sumpio BE. Production of platelet-derived growth factor B chain (PDGF-B) by endothelial cells subjected to cyclic strain in vitro. Surg Forum 45:362-364, 1994.

84. Li G, Mills I, Sumpio BE.Cyclic strain stimulates endothelial cell proliferation: Characterization of strain requirements. Endothelium 22:177-181, 1994.

85. Awolesi MA, Sessa WC, Widmann, M, Sumpio BE. Cyclic strain increases endothelial nitric oxide synthase. Surgery 116: 439-444, 1994.

86. Mills I, Murata K, Packer CS, Sumpio BE. Cyclic strain stimulates dephosphorylation of the 20kDa regulatory myosin light chain in vascular smooth muscle cells. Biochem. Biophys. Res. Com. 205 (1): 79-84, 1994.

87. Gusberg RJ, Peterec SM, Sumpio BE, Meier GH. Splenomegaly associated with Variceal Bleeding - Hemodynamic Basis and Treatment Implications. Hepato-Gastroenterology 41: 573-577, 1994.

88. McMillen MA, Huribal M, Cunningham ME, Kumar R, Sumpio BE. Endothelin-1 increases intracellular calcium in human monocytes and causes production of interleukin 6. Critical Care Med . 23: 34-40, 1995.

89. McMillen M, Sumpio BE. Endothelial-leukocyte interactions in the neutrophil cascade Am. J. Surgery 169: 186-187, 1995.

90. McMillen MA, Sumpio BE. Endothelin, a Polyfunctional Cytokine. J. Am. College of Surgeons 180:621-637, 1995.

91. Resnick N, Sumpio BE, Gimbrone MA. Endothelial Regulation by Biomechanical Forces. Proceedings of Xth International Symposium on Atherosclerosis, Montreal. eds. Woodford, EP Davignion, J Sniderman, A., 1995, p 838-843, Elsevier Press

92. Awolesi MA, Sessa WC, Sumpio BE. Cyclic strain upregulates nitric oxide synthase in cultured bovine aortic endothelial cells. J. Clin. Invest. 96:1449-1454, 1995.

93. Oluwole BO, McMillen MA, Sumpio BE. Endothelial cell control of Vasomotor Tone. Ann. Vasc. Surg. 9(3):293-301, 1995.

94. Du W, Mills I, Sumpio B.E. Cyclic Strain Causes Heterogeneous Induction of Transcription Factors, AP-1, CRE binding protein and NF-kB, in Endothelial Cells: Species and Vascular Bed Diversity. Journal of Biomechanics 28(12):1485-1491, 1995.

95. Baum, Sumpio BE and members of American College of Rapid Technology Assessment Group. Multi center trial to evaluate Vascular magnetic Resonance Angiography of the Lower Extremity. J. Am. Medical Assoc. 1996.

96. Rivas C, Centrella M, Sumpio BE. Stretch stimulates human keratinocyte but not dermal fibroblast proliferation. Surg. Forum 46: 740-742, 1995.

98. Sai-Sudhaker C., Sumpio BE. Cyclic strain activates mitogen-activated protein kinase (MAPK) in bovine aortic endothelial cells. Surg. Forum 46:336-338, 1995.

99. Pena CS, McCauley TR, Price TB, Sumpio BE, Gusberg RJ, Gore JC. Quantitative blood flow measurements with cine phase contrast MR imaging of subjects at rest and after exercise to assess peripheral vascular disease. Am. J. Radiology 167(1): 153-157, 1996

100.Basson M, Li G, Hong F, Han O, Sumpio BE. Amplitude-dependent modulation of brush border enzymes and proiferation by cyclic strain in human intestinal CaCO-2 monolayers. J. Cell. Physiol. 168:476-488,1996

101.Kamal K, Sumpio BE. The Pathobiology of Diabetes Mellitus: Implications for Surgeons. J. Am. Coll. Surg. 183: 271-289, 1996.

102. Yano Y, Geibel J, Sumpio BE. Tyrosine phosphorylation of pp125^FAK and paxillin in aortic endothelial cells induced by mechanical strain. Am. J. Physiol. 271: C635-C649, 1996.

103. Yano Y, Saito Y, Narumiya S, Sumpio BE. Involvement of rho p21 in cyclic strain-induced tyrosine phosphorylation of focal adhesion kinase (pp 125^FAK), morphological changes and migration of endothelial cells. Biochem. Biophys. Res. Commun. 224:508-515, 1996.

104. Koo J, Powell R, Sawyer M, Sumpio BE. Transcriptional regulation of endothelin. Surg. Tech. 5:276-282, 1996.
Powell RJ, Carruth JA, Basson MD, Bloodgood R, Sumpio BE. Matrix specific effect of endothelial cell control of smooth muscle migration. J. Vasc. Surg. 24: 51-57, 1996.

105. Murata K, Mills I, Sumpio BE. Protein phosphatase 2A in stretch-induced endothelial cell proliferation. J. Cell. Biochem. 63: 311-319, 1996.

106. Segurola RJ, Mills I, Elefteriades JA, Sumpio BE. Effects of physical forces on bovine pulmonary endothelial cell proliferation. Surg. Forum. 82: 353-355, 1996.

108. Han O, Sumpio BE, Li G, Basson MD. Repetitive strain modulates human (CaCO-2) intestinal epithelial brush border enzyme activity via PCK-a and -x and tyrosine kinase signals. Surg. Forum. 82: 183-184, 1996

109. Evans L, Frenkel L, Brophy CM, Rosales OR, Sudhaker S, Li G, Du W, Sumpio BE. Activation of diacylglycerol in cultured endothelial cells exposed to cyclic strain. Am. J. Physiol. 41(2): C650-659, 1997.

110. Yano Y, Geibel J, Sumpio BE. Cyclic strain induces reorganization of integrin a 5b 1 and a 2b 1 in human umbilical vein endothelial cells. J. Cell. Biochem. 64:505-513, 1997.

111. Isales CM, Sumpio BE, Bollag R, Zhong Q, Du W, Rodriguez-Commes J, Lopez R, Rosales OR, Gasalla-Herraiz J, McCarthy R. Parathyroid Hormone Stimulates Endothelin-1 Synthesis and Secretion From A Human Umbilical Vein Endothelial Cell Line Through a Calcium Influx-Dependent Mechanism. Endocrinology (In Press).

112. Mills I, Cohen CR, Kamal K, Li G, Shin T, Du W, Sumpio BE. Strain Activation of Bovine Aortic Smooth Muscle Cell Proliferation and Alignment: Study of Strain Dependency and the Role of Protein Kinase A and C Signaling Pathways. J. Cell. Physiol. 170: 228-234, 1997.

113. Chang R., Powell R, Sumpio BE. Tissue plasminogen activator-biological perspective for surgeons. J. Am. Col. Surg. 185:529-539, 1997.

114. Cohen CR, Mills I, Du W, Sumpio BE. Activation of adenylate cyclase, cAMP, PKA pathway in endothelial cells exposed to cyclic strain. Exp. Cell Res. 231:184-189, 1997

115. SaiSudhaker CB, Sumpio BE. Mesenteric Ischemia secondary to cocaine abuse. Am. J. Gastroenterology. 92(6):1053-1054, 1997.

116. Segurola R, Oluwole B, Mill I, Yokoyama C, Tanabe T, Kito H, Nakajima N, Sumpio BE. Cyclic strain is a weak inducer of prostacyclin synthase expression in bovine aortic cells. J. Surg. Res. 69:135-138, 1997.

117. Rosales OR, Isales CM, Barrett PQ, Brophy C, Sumpio BE. Exposure of endothelial cells to cyclic strain induces elevations of cytosolic calcium through mobilization of intracellular and extracellular pools. Biochemical J. 326: 385-392, 1997.

118. Powell RJ, Hydowski J, Frank O, Bhargava J, Sumpio BE. Endothelial cell effect on smooth muscle cell collagen synthesis. J. Surg. Res. 69: 113-127, 1997.

119. Watase M, Awolesi MA, Ricotta J, Sumpio BE. Effect of Pulsatile Pressure on Bovine Smooth Muscle Cells. Life Sciences. 61:987-996, 1997.

120. Takei T, Rivas-Gotz C, Delling CA, Koo JT, Mills I, McCarthy TL, Centrella M, Sumpio BE. The effect of strain on human keratinocytes in vitro. J. Cell Physiol. 173:64-72,1997.

121. Oluwole BO, Du W, Mills I, Sumpio BE. Gene regulation by mechanical forces. Endothelium 5: 85-93, 1997.

122. Takei T, Han O, Ikeda M, Male P, Mills I, Sumpio BE. Cyclic strain stimulates isoform-specific PKC activation and translocation in cultured human keratinocytes. J. Cell Biochem. 67:327-337, 1997.

123. Sumpio B.E., Chang R, Xu W, Wang X, Du, W. Regulation of tissue plasminogen activator in bovine endothelial cells exposed to cyclic strain: The functional significance of the CRE, AP-2 and SSRE sites. Am. J. Physiol. 42(5): C1441-1448, 1997.

124. Schneider SW, Yano Y, Sumpio BE, Jena B, Geibel JP, Oberleithner. Endothelial cells swell rapidly in response to aldosterone measured with atomic force microscopy. Int. Cell Biol. (In Press)

125. SaiSudhaker CB, Al-hakeem M, Sumpio BE. Venous obstruction of the lower extremity secondary to an enlarged bladder.Conn. Med. 61: 459-460, 1997.

126. Ikeda M, Takei T, Mill s I, Sumpio BE. Extracellular signal-regulated protein kinase 1 and 2 activation by hemodynamic forces in endothelial cells. Surg. Forum 83: 366-368, 1997.

127. Powell R, Roddy S, Conte M, Meier G, Gusberg R, Sumpio BE. Effect of renal insufficiency on outcome following infrarenal aortic surgery. Am. J. Surgery 174 (2): 126-130, 1997.

128. Powell R, Bhargava J, Sumpio BE. Regulation of smooth muscle cell differentiation and expression of nonmuscle myosin by endothelial cells in co-culture. Surg. Forum 83: 408-410, 1997.

129. Kito H, Yokoyama C, Inoue H, Tanabe T, Nakajima N, Sumpio BE. Cycloxygenase expression in bovine aortic endothelial cells exposed to cyclic strain. Endothelium 28:1-6, 1997.

130. Schulz J, Sumpio BE, Gusberg RJ. Cocaine - Associated Myocardial and Mesenteric Ischemia: A Case Report and Review of the Literature. Angiology 7:1-5,1998.

131. Sumpio BE, Du W, Wang X, Gallagher G, Khachigian L, Collins T, Gimbrone M, Resnick N. Regulation of PDGF-B in endothelial cells exposed to cyclic strain. Arteriosclerosis, Thrombosis and Vascular Biology 18:349-355, 1998.

132. Takei T, Kito H, Du W, Mills I, Sumpio BE. Induction of interleukin-1a and b gene expression in human keratinocytes exposed to repetitive strain: Their role in strain-induced keratinocyte proliferation and morphological change. J. Cell. Biochem. 69:95-103, 1998.

133. Powell R, Bhargava J, Sumpio BE. Co-culture conditions alter endothelial modulation of TGF-B1 activation and smooth muscle growth morphology. Am J. Physiol. 274(2 Pt 2):H642-9, 1998

134. Vouyouka A, Powell R, Ricotta J, Chen H, Dudrick D, Sawmiller C, Dudrick S, Sumpio BE. Ambient pressure modulates endothelial cell proliferation. J. Mol. Cell. Cardiol. 30(3): 609-615, 1998.

131. Takei T, Mills I, Arai K, Sumpio BE. Molecular basis for tissue expansion: clinical implications for surgeons. Plastic Reconstr. Surg. 102 (1):247-259, 1998.

136. Segurola RJ, Mills I, Sumpio BE. Strain-induced Dual Alignment of L6 Rat Swkeletal Muscle Cells. In Vitro Cell Dev Biol. 34:609-612, 1998.

137.Kamal K, Du W, Mills I, Sumpio BE. Antiproliferative effect of elevated glucose in human microvascular endothelial cells. J. Cell. Biochem. 71:491-501.

138. Ikeda M, Takei T, Mills I, Sumpio BE. Calcium-independent activation of extracellular signal regulated kinases 1 and 2 by cyclic strain. Biochem. Biophys. Res. Com. 247:462-465, 1998.

139. Sawmiller CJ, Powell RJ, Quader M, Dudrick SJ, Sumpio BE. The differential effect of contrast agents on endothelial and smooth muscle growth in vitro. J. Vasc. Surg. 27: 1128-40, 1998.

140. Han O, Sumpio BE, Basson, M. Deformation alters CaCO-2 intestinal epithelial proliferation and phenotype by PKC and tyrosine kinase signals. Am. J. Physiol. 275(3 Pt 1): G534-41, 1998.

141. Sawyer MD, van Raaij T, Cross J, Sumpio BE. Novel potentiation of interleukin 1 alpha production in endotoxin stimulated IC-21 cells by ambient pressure augmentation. Arch. Surg. 133(4): 438-441, 1998.

142. Quader M, Sawmiller C, Sumpio BE. Contrast-induced nephropathy: Review of incidence and pathophysiology. Ann. Vasc. Surg. 12:612-620, 1998.

143. Gahtan V, Peyman J, Sumpio BE. Understanding Molecular Biology. Sem Vasc. Surg. 11:125-133, 1998.

144. Quader M, Sumpio BE. Low molecular weight heparin: Review. J. Am. Col. Surg. 187 (6):641-658, 1998.

145. Kito H, Chen E, Mills I, Ikeda M, Sumpio BE. Cyclic stretch of pulmonary arterial endothelial cells activates different mitogen-activated protein kinase subtypes. Surg. Forum 49:287-288, 1998.

146. Ikeda M, Takei T, Mills I, Kito H, Sumpio BE. Extracellular signal-regulated kinases 1 and 2 activation in endothelial cells exposed to cyclic strain. Am. J. Physiol. 276: Hxxx-xxx, 1999.

147. Gahtan V, Wang X, Tuszynski GP, Rothman VL, Sumpio BE. Signaling pathways by which thrombospondin-1 promotes vascular smooth muscle cell proliferation and chemotaxis. Surg. Forum 49: 309-311, 1998.

Book Chapters

1. Evans L, Sumpio BE. The Role of Mechanical Forces In Vitro in the Development of Intimal Hyperplasia. In Myointimal Hyperplasia, P. B. Dobrin (ed), RG Landes Publishers, Austin, Texas, p 111-134, 1994.

2. Mills I, Cohen CR, Sumpio BE. Cyclic strain and Vascular Cell Biology. In Hemodynamic Forces and Vascular Cell Biology, Sumpio BE (ed) RG Landes Publishers, Austin, Texas, p 66-89, 1993.

3. Isales C, Rosales O, Sumpio BE. Mediators and mechanisms of cyclic strain and shear stress-induced vascular responses. In Hemodynamic Forces and Vascular Cell Biology, Sumpio BE (ed) RG Landes Publishers, Austin, Texas, p 90-115, 1993.

4. Peyman J, Sumpio BE. Molecular Biology for Surgeons. In, Basic Science of Vascular Disease, Sumpio BE and Sidawy AS (editors), Futura Publishing Co., Mt. Kisco, N.Y., pp 17-68, 1997

5. Gallagher G, Sumpio BE. Vascular Endothelial Cell. In, Basic Science of Vascular Disease, Sumpio BE and Sidawy AS (editors), Futura Publishing Co., Mt. Kisco, N.Y. pp. 151-186, 1997

6. Mills, I, Sumpio BE. Smooth Muscle Cells. In, Basic Science of Vascular Disease, Sumpio BE and Sidawy AS (editors), Futura Publishing Co., Mt. Kisco, N.Y., pp 187-226, 1997

7. Brophy CM, Awolesi MA. Sumpio BE. Molecular mechanisms of Vasospasm. In, Basic Science of Vascular Disease, Sumpio BE and Sidawy AS (editors), Futura Publishing Co., Mt. Kisco, N.Y. pp.367-384, 1997.

8. Sumpio BE, Oluwole B, Wang X, Awolesi M. Regulation of nitric oxide synthase expression and activity by hemodynamic forces. In The Pathophysiology and Clinical Applications of Nitric Oxide, Rubanyi GM (editor), Harwood Academic Publishers, Reading, U.K. Chapter 10 pp. 171-193, 1998.

9. Sai Sudhaker CB, Pollock JS, Sumpio BE. Acute mesenteric ischemia. In Textbook in Angiology, Chang J (editor), Springer-Verlag, Chapter 46 pp. 1-40.

10. Kamal K, Chang R, Sumpio BE. Diabetic Vascular Disease: Biochemical and Molecular Perspectives. In Textbook in Angiology, Chang J (editor), Springer-Verlag, Chapter 68 pp. 1-59.

11. Chang R, Kamal K, Sumpio BE. Tissue plasminogen Activator- Biological Perspectives for Surgeons. In Textbook in Angiology, Chang J (editor), Springer-Verlag, Chapter 69 pp. 1-59.

12. Mills I, Sumpio BE. Mechanical Forces and Cell Differentiation. In Tissue Engineering of Prosthetic Vascular Grafts, Zilla PM and Greisler HP (editors), R. G. Landes Company, Austin TX, Chapter 39, pp 423-436.
 
 

Miscellaneous:

1. Sumpio BE. Endothelial Seeding in Vascular Surgery (Book Review).J Vasc Surg 6:101, 1987.

2. Sumpio BE. The Kidney in Hypertension (Book Review). J Vasc Surg 6:626, 1987.

3. Sumpio BE (editor) Hemodynamic Forces and Vascular Cell Biology, 1993, RG Landes Publishers, Austin, Texas

4. Sumpio BE and Sidawy AS (editors) Basic Science in Vascular Disease, Futura Publishing Co., Mt. Kisco, N.Y. 1997.

Presentations:

1. Federation of American Society of Experimental Biology. Characteristics of a non-filtering isolated rat kidney preparation. Atlantic City, New Jersey, April 1978.

2. American Society of Nephrology. Catabolism of B2 microglobulin and cytochrome C by the isolated kidney. Washington, DC, November 1980.

3. Federation of American Society of Experimental Biology. Tubular absorption of low molecular weight proteins: kinetics, competition and selectivity. Atlanta, GA, April 1981.

4. Shock Society. Enhanced Functional Recovery of Isolated Kidneys Subjected to Warm Ischemia after Treatment with ATP-MgCl₂.Jackson Hole, WY, June 1983.
5. Federation of American Society of Experimental Biology. NMR spectra and function of Ischemic Isolated Kidney Reperfused with Phosphate Free Buffer and Treated with ATP-MgCl₂. Atlanta, GA, April 1984.

6. Shock Society. Amelioration of Gentamicin Nephrotoxicity by ATP-MgCl₂ Treatment. Toronto, Canada, June 1984.

7. New England Vascular Society. Comparison of Results of Aortic Grafting in Occlusive and Aneurysmal Disease. Dixville Notch, New Hampshire, October 1984.

8. Surgical Forum, American College of Surgeons. Nuclear Magnetic Resonance Study Showing the Reperfusion Injury Following Ischemia and Its Improvement with ATP-MgCl₂.

9. Association of Academic Surgeons. Amelioration of Gentamicin and Cis-platinum Nephrotoxicity by ATP-MgCl₂. San Antonio, Texas, November, 1984.

10. Federation of American Society of Experimental Biology. Renal Handling of Exogenous ATP-MgCl₂. Anaheim, California, April 1985.

11. Shock Society. Comparison of adenosine-MgCl₂ and ATP-MgCl₂ effects in the isolated perfused kidney. Baltimore, Maryland, June 1985.

12. Surgical Forum, American College of Surgeons. Alleviation of Cyclosporine-induced Nephrotoxicity with ATP-MgCl₂ and Verapamil. Chicago, Illinois, October 1985.

13. Society of University Surgeons (Residents' Forum). Effect of Immunosuppression regimens on circulating T-lymphocyte subsets. Richmond, Virginia, February 1986.

14. Federation of American Society of Experimental Biology. Cyclosporine Toxicity in the Isolated Kidney. St. Louis, Missouri, April 1986.

15. Shock Society. Comparison of Effects of ATP-MgCl₂ and Adenosine MgCl₂ on Renal Function Following Ischemia. Scottsdale, Arizona, June 1986.

16. Surgical Forum, American College of Surgeons. Verapamil and ATP-MgCl₂ Prevents Cyclosporine Induced Nephrotoxicity by Improving Mitochondrial and Tissue Ca²⁺/Mg²⁺. New Orleans, Louisiana, October 1986.

17. Southern Association for Vascular Surgery. Response of Aortic Endothelial Cells to Mechanical Cyclic Stretching. Scottsdale, Arizona, January 1987.

18. 20th Hugh Lofland Conference on Arterial Wall Metabolism. Effect of Mechanical Stress on Endothelial and Smooth Muscle Cell Biology in Culture. Winston-Salem, North Carolina. May 1987.

19. North Carolina Chapter of American College of Surgeons. Influence of Perfusate Viscosity and Oncotic Pressure on Renal Function. Myrtle Beach, South Carolina, May 1987.

20. Grand Rounds, Stanford University Medical Center. Management of Acute Renal Failure. Palo Alto, California, November 1986.

21. Grands Rounds, University of North Carolina. Role of Vascular Stress on Cells in Culture. Chapel Hill, North Carolina, January 1987.

22. International Society for Cardiovascular Surgery. Alterations in Endothelial Cell Morphology and Cytoskeletal Proteins During Repetitive Mechanical Stress. Toronto, Canada, June 1987.

23. Shock Society. Effects of Viscosity and Oncotic Pressure on the Function of Isolated Perfused Rat Kidneys. Montreal, Canada, June 1987.

24. New England Vascular Society. Cyclic Stretching of Aortic Smooth Muscle Cells Stimulates Collagen Synthesis. Bretton Woods, New Hampshire, Sept. 1987.

25. Association for Academic Surgery. Response of aortic endothelial cells and smooth muscle cells to pulsatile stretching in culture. Orlando, Florida , November 1987.

26. Association for Academic Surgery. Effect of perfusate viscosity, RBC deformability and drag on the function of an isolated kidney. Orlando, Florida, November 1987.

27. The Second International Congress on Cyclosporine. Cyclosporine toxicity in an isolated perfused kidney. Washington, D.C., November 1987.

28. Society of University Surgeons. Mechanical stretching of cultured endothelial cells: effect on prostacyclin synthetic activity. San Antonio, Texas, February 1988.

29. Shock Society. The effect of RBC deformability and fluid drag on renal function. Fontana, Wisconsin, June, 1988.

30. Gordon Conference. Mechanical stretching of vascular cells. Meriden, New Hampshire, August 1988.

31. NIH Research Initiatives in Vascular Disease (Invited Speaker). Mechanical stress and cell growth. Bethesda, Maryland, March 1989.

32. Federation of American Society of Experimental Biology. Repetitive mechanical stretching of aortic endothelial cells in culture: inhibition of collagen synthesis. New Orleans, La, March 1989.

33. Invited Speaker, University of Michigan. Role of mechanical stress in cell growth. Ann Arbor, MI, June 1989.

34. International Society for Cardiovascular Surgery, Toronto. The role of adenylate cyclase in the transduction of pulsatile stretch signals to endothelial cells in culture. Toronto, Canada, September 1989.

35. New England Society for Vascular Surgery. Salvage of large ischemic soft-tissue and bony defects of the lower extremity with revascularization and "local" flap coverage. Bretton Woods, New Hampshire, September 1989.

36. Surgical Forum, American College of Surgeons. Interleukin-6 production by vascular smooth muscle cells during cyclic stretch: etiology of SMC quiesence in vivo? Atlanta, Georgia, October 1989.

37. Association for Academic Surgery. Collagen synthesis is inhibited in aortic endothelial cells subjected to cyclic stretch in vitro. Louisville, Kentucky, November 1989.

38. Visiting Professor, University of California, San Francisco. Exercising endothelial cells in culture. San Francisco, CA. February 1990.

39. Society for University Surgeons. Enhanced production of a smooth muscle cell contracting factor by endothelial cells subjected to pulsatile stretch in vitro. Los Angeles, CA. February 1990.

40. Federation of American Society of Experimental Biology. Endothelin production by endothelial cells subjected to pulsatile stretch in vitro. Washington, D.C. April 1990.

41. Gore Lecture (Invited Speaker). Role of hemodynamics in cell growth. Boston, MA. April, 1990.

42. Gladstone Foundation (Invited Speaker). Modulation of endothelial cell phenotype by cyclic stretch. San Francisco, August, 1990.

43. Visiting Professor, Bay State Medical Center, Springfield, MA. Endothelial cells alterations with external forces. October 1990.

44. NIH Research Initiatives in Vascular Disease (Invited Speaker) Hemodynamic Forces and the Biology of the Endothelium: Signal Transduction Pathways in Endothelial Cells Subjected to Physical Forces In Vitro. Bethesda, MD. February 1991.

45. Invited speaker, Workshop on Mechanical Stress Effects on Vascular Cells, Atlanta, Ga. Tissue plasminogen activator production and phosphoinositide activation in cultured human endothelial cells subjected to cyclic strain. April, 1991.

46. Gordon Conference on Atherosclerosis (Invited speaker). Phosphatidylinositol activation of endothelial cells exposed to cyclic strain. Meriden, New Hampshire, June 1991.

47. Invited Speaker, Whitaker Foundation. Mechanical deformation of endothelial cells grown on different biomaterials and surfaces. Snowbird, Utah, Aug. 1991.

48. Invited speaker, World Congress for Microcirculation. Microfilament reorientation in endothelial cells subjected to pulsatile stretch. Louisville, KY. Sept. 1991.

49. NIH Research Initiatives in Vascular Disease (Invited Speaker) Molecular biology and the vascular surgeon: Fundamental concepts and the tools. Bethesda, MD. Feb. 1992.

50. Invited speaker. Fundamentals of surgical research course. Research hypothesis and design, Chicago, Il. July 1992.

51. Guest faculty. Thrombosis, Thromboembolism and Thrombolysis Post-graduate Course. The aortic arch and carotid vessels as sources of stroke, New Haven, August 1992.

52. Visiting Professor, Loyola University Medical Center, Chicago, IL. Mechanisms by of EC coupling to external forces: implications for intimal hyperplasia. Sept. 1992.

53. New England Society for Vascular Surgery. Smooth muscle cell inhibition by 8-methoxypsoralen phototherapy. Dixville Notch, New Hampshire Sept. 1992.

54. American College of Surgeons, Surgical Forum (Vascular Surgery). Are G-proteins mechanosensors for endothelial cells? New Orleans, LA, Oct 1992.

55. Grand Rounds Speaker, University of Connecticut School of Medicine. Mechanisms by which endothelium senses changes in hemodynamics: Implications for the pathogenesis of atherosclerosis and intimal hyperplasia. Hartford, CT. Oct. 1992.

56. International Society for Applied Cardiovascular Biology (Invited Speaker). Signal transduction mechanisms of endothelial cells subjected to cyclic strain. St. Louis, MO. November 1992.

57. Invited Speaker, American Heart Association, CT Affiliate. How does the endothelium sense the changing circulation?, Meriden, CT December 1992

58. Invited Faculty, Angioscopy Course sponsored by Harvard Medical School. Molecular Biology for Vascular Surgeons. Boston, MA, December 1992.

59. Visiting Professor, Framingham Union MetroWest Medical Center. Mechanisms by which the endothelium senses changes in hemodynamics. Framingham, MA, February 1993.

60. Invited Speaker Controversies in Surgery 1993: Basic Science for the General Surgeon. Farmington, CT. March 1993.

61. Visiting Professor, University of Pittsburgh. How does the endothelium sense changes in hemodynamics? Pittsburg, PA. March 1993.

62. Young Investigator Award (Invited Speaker) Japan Surgical Society. Nitric Oxide Synthase Induction in Endothelial Cells. Sendai, JAPAN, March 1993.

63. Visiting Professor, Chiba University Medical School. From Bench to Bedside- How EC Sense Changes in Hemodynamics., Chiba, JAPAN, March 1993.

64. Invited Symposium Speaker, Experimental Biology Meeting. Signal Transduction Mechanisms in Vascular Cells Exposed to Strain. New Orleans, LA, April 1993.

65. Invited Speaker, Vascular Forum. Atherogenesis. New Haven, CT. June 1993.

66. Guest faculty. Thrombosis, Thromboembolism and Thrombolysis Post-graduate Course. The aortic arch and carotid vessels as sources of stroke, New Haven, August 1993.

67. Invited Speaker. International Vascular Conference. Effect of mechanical forces on vascular cells. Beijing, CHINA. October 1993.

68. Visiting Professor. Osaka University Medical College. Mechano-transduction systems in endothelial cells. Osaka, JAPAN, October 1993.

69. Invited Speaker, American Society for Cell Biology: Symposium on Heterogeneity of Vascular Cell Responses., New Orleans, LA. December 1993.

70. NIH Research Initiatives in Vascular Disease (Invited Speaker) Research Models in Vascular Disease: Development of Pulsatile Pressure and Cyclic Strain Models. Bethesda, MD. February 1994.

71. Invited Speaker. American Physiological Society Conference on Mechanotransduction and the regulation of Cell Growth and Differentiation. Biochemical and cytoskeletal signaling with cyclic strain. Sarasota, FL. October 1994.

72. Invited Speaker. Department of Physiology, University of Connecticut. Gene regulation by mechanical forces. Farmington, CT. February 1995.

73.Young Investigator Award (Invited Speaker) Japan Surgical Society. Effect of pulsatile pressure on endothelial cell proliferation Nagoya, JAPAN, April 1995.

74.Invited Speaker. Department of Physiology, Nagoya University School of Medicine. Insights into the coupling of mechanical forces and vascular cell response. Nagoya, JAPAN, April 1995.

75. International Society for Applied Cardiovascular Biology (Invited Speaker). Mechanical forces and gene regulation. Manchester, England March 1996.

76. Visiting Lecturer. Rayne Institute Center for Cardiopulmonary Diseases. Transcriptional regulation by cyclic strain. London, U.K. March 1996.

77. Invited Speaker. William Harvey Institute. Nitric oxide syntahase gene regulation by cyclic strain. London, U.K. March 1996.

78. Invited Speaker Australasian Society for Vascular Surgery. May 4-11^th, 1996

79. (Invited Speaker) Japan Society for Vascular Surgery. Gene therapy for vascular diseases-Does it make sense or anti-sense? Asahikawa, JAPAN, June 1996.

80. Invited Speaker Gordon Conference on Bioengineering and Orthopedic Sciences. Focal Adhesion proteins as mechanotransducers. Andover, New Hampshire, July 1996

81. Invited Professor. Beth Israel Deaconess Dept. of Surgery. Future therapy for atherosclerosis. Boston, MA Feb. 1997.

82. Invited Speaker. NIH Research Initiatives. Wall stress regulation of endothelial cells. Bethesda, MD, Feb. 1997.

83. Moderator for Educational panel, Association of Program Directors in Surgery, San Diego, CA, April 1997.

84. Visiting Professor. University of Nebraska Medical Center. Atherosclerosis- Was Osler right?. Omaha, NE, April 1997.

85. Invited Speaker. International College of Angiology. Vascular disease and biology, Istanbul, Turkey, June 1997.

86. Invited Speaker. Japanese Society for Abdominal Emergency Medicine. Mesenteric Vascular Emergencies: Thoughts for the new millenium. Urayasu, JAPAN, September 1997.

87. Invited Speaker. International Atherosclerosis Society. Bordeaux, Paris, FRANCE. October 1997.

88. Distinguished Visiting Scientist. Department of Physiology and Cell Biology, Albany Medical College, Albany, New York. October 1997.

89. Invited Speaker. Philippine Stroke Society. Baguio City, PHILIPPINES, November 1997.

90. Visiting Professor, Dartmouth Medical Center, Atherosclerosis-From molecules to man Hanover, N.H. November 1997.

91. Visiting Professor, New York Hospital Cornell University Medical Center, Atherosclerosis-, New York January 1998.

92. Invited Speaker, New England Surgical Society Spring Meeting, New Haven, CT, March 1998.

93. Invited Speaker, Asian Vascular Society, Gene Therapy- Hope or Hype?, Beijing China, May 1998.

94. Invited Speaker, International Society for Heart Research, Regulation of NOS expression in response to mechanical load in the vascular system., Rhodes, Greece, May 1998.

95. Invited Speaker, International Union of Angiology, is the Geometry of a Vascular Anastamosis Important?, Tokyo, Japan, September 1998