YALE UNIVERSITY
PHOTOBIOLOGY LABORATORY (YUPL)
Francis P. Gasparro, Ph.D., Director
YUPL --> JUPL
The Yale University Photobiology Lab has moved to
Philadelphia.
It is housed in the Department of
Dermatology and Cutaneous
Biology at Thomas Jefferson University.
Contact information:
Francis P. Gasparro, PhD, Director
Jefferson University Photobiology Lab
Department of Dermatology & Cutaneous Biology
233 South 10th St (Room 428)
Philadelphia, PA 19107-5541
phone 215 503 3327
fax 215 503 3322
email - coming soon but in the meantime send email to
my AOL address: fotondoc@A0L.com
Mission
The mission of YUPL is to explore the photobiology of psoralens, a
class of compounds originally used in the treatment of cutaneous
diseases. The prototypical member of the family, 8-methoxypsoralen
(8-MOP), was originally developed for the treatment of psoriasis by
TB Fitzpatrick and JA Parrish at Harvard in the early 1970s.
Psoralen activated with UVA (320-400 nm radiation) was
remarkable for its ability to control psoriasis. In the 1980s an
extracorporeal modality was developed and brought to the market
by Therakos Inc. to treat T cell disorders and received FDA
approval for the treatment of the rare disease cutaneous T cell
lymphoma in 1987. Since then extracorporeal photochemotherapy
(ECP) has been shown to be effective for many other immune
disorders (scleroderma, arthritis, lupus erythematosus, graft versus
host disease and the prevention of cardiac graft rejection). Clinical
trials for scleroderma and cardiac graft rejection are currently
under way.
Thomas Jefferson University, Dermatology And Cutaneous Biology
Print a Sample Submission & Report Form
About Psoralen Blood Levels
Important Numbers
Current Laboratory Personnel
YUPL Alumni/Alumnae - Where are they now?
Psoralen Hall of Fame (Pantheon)
Photobiology Online
Dermatology Vienna
ICP'96 Vienna Austria - A Royal Success
Coming Soon:
- PUVA for Psoriasis
- Photopheresis for CTCL
- Psoralen Photochemistry and Photobiology -
A Primer
- Cellular Effects
- Mechanistic Events - chromatin rearrangement, gene induction
(to see how this works - check out: Henderson D & Hurley LH:
Nature Medicine 1: 525-527 (1995) "Molecular struggle for
transcriptional control")
- Photobiology Resources - lights, psoralen, action
- Participant in ICN's PUVA Outcomes Management Program
(POMP)
YUPL is supported by Research Grants from
Last Update: Dec.23,1996 Peter Donath, MD
