Department of Psychiatry Faculty

Wei-Xing Shi, PhD Assistant Professor Psychiatry SHM B272 Tel: 203-785-4507 Fax: 203-785-7670 Email: wei-xing.shi@yale.edu

Education

1982, B.Sc., Nanjing University
1990, Ph.D., Yale University
Fellowship: Columbia University

Research Interest

My research interests are in dopamine (DA)-mediated synaptic transmission in the brain and related disorders such as schizophrenia, Parkinson's disease and substance abuse. Current researches include studies of (1) the mechanisms through which the activity of DA neurons is controlled, including DA cells' intrinsic membrane properties, feedback and non-feedback synaptic input to DA neurons; (2) the effect of DA on DA target neurons, particularly those in the prefrontal cortex and (3) pre-and postsynaptic modulation of DA transmission by drugs used for treating the above mentioned disorders. Techniques used in these studies include whole cell recordings from visually identified neurons in thin brain slices, single unit recordings in awakened animals, retrograde labeling and immunocytochemistry.

Publications of Note

Shi, WX, Zheng P, Liang XF, Bunney BS (1997) Characterization of dopamine-induced depolarization of prefrontal cortical neurons. Synapse 26:415-422.

Shi WX, Smith PL, Pun CL, Millet B and Bunney, BS (1997) D1-D2 interaction in feedback control of midbrain dopamine neurons. Journal of Neuroscience in press.

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