Department of Psychiatry Faculty

John H. Krystal, MD Robert L. McNeil, Jr., Professor of Clinical Pharmacology Deputy Chairman for Research, Department of Psychiatry Director: NIAA Center for the Translational Neuroscience of Alcoholism Clinical Neuroscience Division, National Center for PTSD, DVA Alcohol Research Center, DVA Medical Director, Schizophrenia biological Research Center, DVA

VA Connecticut Healthcare System (116-A)
950 Campbell Ave.
West Haven, CT 06516
T: 203-937-4790; F: 203-937-3468
Email: john.krystal@yale.edu

Clinical Neuroscience Research Unit
Abraham Ribicoff Research Facilities
Connecticut Mental Health Center
34 Park St., New Haven, CT 06519
T: 203-974-7538; F: 203-974-7662

Education

1980, B. A., University of Chicago
1984, M.D., Yale University School of Medicine
1988, Psychiatry Residency, Yale University School of Medicine

Research Interest

My primary research interest is the integration of translational neuroscience research techniques (molecular genetics, molecular brain imaging, functional brain imaging, neurophysiology, psychopharmacology) to characterize molecular mechanisms that contribute to neural network dysfunction underlying symptoms and cognitive deficits in psychiatric disorders. A parallel emphasis of my research is to develop novel pharmacotherapies for these deficits in patients and in human laboratory-based models. Much of my work has focused on the interplay of glutamate, GABA, and dopamine systems in human cortico-limbic circuitry and its relevance for schizophrenia, alcoholism, and stress-related disorders.

Service:
Chairman, NIMH Board of Scientific Counselors (2004-2006) Chairman, Research Task Force, VA New Freedom Commission on Mental Health (2004-2006) Managing Editor, Psychopharmacology; Editorial Board: Biological Psychiatry, Current Psychiatry Reviews, Journal of Dual-Diagnosis

Selected Honors:
Joel Elkes International Award, ACNP (2001)
Hans-Jörg Weitbreicht Preis für Klinische Neurowissenschaften (2003)
ISI-Thomson "Most Highly Cited Researcher" (top 0.5% of cited authors) (2004)
Kempf Award for Research Development in Psychobiology, APA (2005)

Selected Recent Publications

Cavus I, Kasoff W, Cassaday M, Jackob R, Gueorguieva R, Sherwin R, Krystal JH, Spencer D, Abi-Saab W. Interictal extracellular neurometabolite levels in the human hippocampus and cortex: implications for energy metabolism in epilepsy. Annals of Neurology 2005; 57(2):226-235.

Goddard AW, Mason GF, Rothman DL, Behar KL, Krystal JH. Impaired GABA neuronal response to benzodiazepine administration in panic disorder. American Journal of Psychiatry 2004;161:2186-2193

Jacobsen LK, D'Souza DC, Mencl WE, Pugh KR, Skudlarski P, Krystal JH; Nicotine effects on brain function and functional connectivity in schizophrenia. Biological Psychiatry, 2004;55:850-858

Kaufman J, Yang B-Z, Douglas-Palumberi H, Houshyar S, Lipschitz D, Krystal JH, Gelernter J. Social supports and serotonin transporter gene moderate depression in maltreated children. Proceedings of the National Academy of Sciences USA 2004;101(49):17316-17321

Krystal JH, Abi-Saab W, Perry E, D'Souza DC, Liu N, Gueorguieve R, McDougall L, Hunsberger T, Belger A, Levine L, Breier A. Preliminary evidence of attenuation of the disruptive effects of the NMDA glutamate receptor antagonist, ketamine, on working memory by pretreatment with the the group II metabotropic glutamate receptor (mGluR) agonist, LY354740, in healthy human subjects. Psychopharmacology 2005;179:303-309

Krystal JH, Perry EB Jr, Belger A, Madonick SH, Abi-Dargham A, Cooper T, Casselo K, MacDougall L, Abi-Saab W, D'Souza DC. Comparative and interactive human psychopharmacologic effects of ketamine and amphetamine: implications for glutamatergic and dopaminergic model psychoses and cognitive function. Archives of General Psychiatry 2005;62:985-995

Mason GF, Petrakis IL, de Graaf RA, Appel M, Gueorguieva R, Ruff E, Coric V, Epperson CN, Rothman DL, Krystal JH. Cortical GABA levels and the recovery from alcohol dependence: relationship to neurotoxicity and cigarette smoking. Biological Psychiatry 2005; Epublication

Petrakis IP, Limoncelli D, Gueorguieva R, Boutros NN, Trevisan L, Gelernter J, Krystal JH. Altered NMDA glutamate receptor antagonist response in individuals with a familial vulnerability to alcoholism. American Journal of Psychiatry 2004(10):1776-1782

Pilowsky LS, Bressan RA, Stone JM, Erlandsson K, Mulligan RS, Krystal JH, Ell PJ. First in vivo evidence of an NMDA receptor deficit in medication-free schizophrenic patients. Molecular Psychiatry 2005; Epublication

Staley JK, Gottschalk PC, Petrakis I, Zoghbi S, Verhoeff NP, Seibyl JP, Van Dyck C, Innis RB, Krystal JH. Cortical GABA-A receptors in recovery from alcohol dependence: relationship to features of alcohol dependence and cigarette smoking. Archives of General Psychiatry 2005;62:877-888

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