Department of Psychiatry Faculty

Thomas R. Kosten, MD Professor of Psychiatry Deputy Chief of Psychiatry Research VA Connecticut Healthcare System Department of Psychiatry - 151D 950 Campbell Avenue Bldg. 35 West Haven, CT 06516 Tel: 203-932-5711, 7438 Fax: 203-937-4915

Research Interest

My research focuses on the treatment of cocaine dependent humans. My major research area is psychopharmacology using medications to treat cocaine abuse, such as the antidepressant desipramine, the dopamine agonist amantadine, and the partial opioid agonist buprenophine. While these projects are mostly large scale, outpatient, randomized, clinical trials, smaller pilot studies using new medications are also routinely undertaken and offer the opportunity for student participation. Other studies focus on psychiatric disorders in substance abusers and on the human neurobiology of substance dependence. The neurobiology studies include SPECT neuroimaging of cerebral blood flow in cocaine abusers and treatment of their perfusion defects, which appear due to cocaine abuse.

Publications of Note

Schottenfeld RS, Pakes JR, Oliveto A, Ziedonis D, Kosten TR. Buprenorphine vs. methadone maintenance treatment for concurrent opioid dependence and cocaine abuse. Archives of General Psychiatry 54(8):713-20, 1997.

Kosten TR. Pharmacotherapy of cerebral ischemia in cocaine dependence. Drug and Alcohol Dependence, in press.

Copyright © . Yale University School of Medicine, Psychiatry Department. All rights reserved.
Comments or suggestions to the site editor.

Home URL: http://info.med.yale.edu/ysm