Department of Psychiatry Faculty

Judson Brewer, MD, PhD Assistant Professor of Psychiatry Medical Director, Yale Therapeutic Neuroscience Clinic VA Connecticut Healthcare System 950 Campbell Ave. Building 36 West Haven, CT 06516 Tel:203-937-4840 Fax: 203-937-3478 Email: judson.brewer@yale.edu

Education

A.B. 1992-96 Chemistry, cum laude Princeton University
M.D. 1996-04 Medical Scientist Training Program, Washington University SOM
Ph.D. 1998-02 Graduate Program in Immunology, Washington University SOM

Research Interest

My primary research interest is the elucidation of neurobiological mechanisms underlying the interface between stress, cognitive control and the addictive process, and in developing effective means for the modulation of these processes to better treat substance use disorders. In such, the primarily focus of my laboratory is on studying mindfulness training as a mechanistic probe and treatment for addictions. Using neurobiologic and physiologic probes such as fMRI, skin conductance, and heart rate variability, we measures the effects that mindfulness training has on stress provocation and treatment outcomes in individuals with addictive disorders.

Publications of Note

Brewer, J. A., O. Kanagawa, B. P. Sleckman and L. J. Muglia (2002). "Thymocyte apoptosis induced by T cell activation is mediated by glucocorticoids in vivo." Journal of Immunology 169(4): 1837-43.
Brewer, J. A., B. P. Sleckman, W. Swat and L. J. Muglia (2002). "Green fluorescent protein-glucocorticoid receptor knockin mice reveal dynamic receptor modulation during thymocyte development." Journal of Immunology 169(3): 1309-18.
Brewer, J. A., S. K. Vogt, B. P. Sleckman, W. Swat, O. Kanagawa and L. J. Muglia (2002). "Knock-ins and conditional knockouts: in vivo analysis of glucocorticoid receptor regulation and function." Endocrine Research 28(4): 545-50.
Frank, D. U., L. K. Fotheringham, J. A. Brewer, L. J. Muglia, M. Tristani-Firouzi, M. R. Capecchi and A. M. Moon (2002). "An Fgf8 mouse mutant phenocopies human 22q11 deletion syndrome." Development 129(19): 4591-603.
Brewer, J. A., K. E. Bethin, M. L. Schaefer, L. M. Muglia, S. K. Vogt, S. C. Weninger, J. A. Majzoub and L. J. Muglia (2003). "Dissecting adrenal and behavioral responses to stress by targeted gene inactivation in mice." Stress 6(2): 121-5.
Brewer, J. A., B. Khor, S. K. Vogt, L. M. Muglia, H. Fujiwara, K. E. Haegele, B. P. Sleckman and L. J. Muglia (2003). "T-cell glucocorticoid receptor is required to suppress COX-2-mediated lethal immune activation." Nature Medicine 9(10): 1318-22.
Boyle, M. P., J. A. Brewer, S. K. Vogt, D. F. Wozniak and L. J. Muglia (2004). "Genetic dissection of stress response pathways in vivo." Endocrine Research 30(4): 859-63.
Boyle, M. P., J. A. Brewer, M. Funatsu, D. F. Wozniak, J. Z. Tsien, Y. Izumi and L. J. Muglia (2005). "Acquired deficit of forebrain glucocorticoid receptor produces depression-like changes in adrenal axis regulation and behavior." Proceedings of the National Academy of Sciences of the United States of America 102(2): 473-8.
Usuku, T., M. Nishi, M. Morimoto, J. A. Brewer, L. J. Muglia, T. Sugimoto and M. Kawata (2005). "Visualization of glucocorticoid receptor in the brain of green fluorescent protein-glucocorticoid receptor knockin mice." Neuroscience 135(4): 1119-28.
Kim, H.-J., H. Zhao, H. Kitaura, S. Bhattacharyya, J. A. Brewer, L. J. Muglia, F. P. Ross and S. L. Teitelbaum (2006). "Glucocorticoids suppress bone formation via the osteoclast." J. Clinical Investigation 116(8): 2152-60.
Grant, J., E., J. A. Brewer, M. N. Potenza, (2006) “Neurobiology of Substance and Behavioral Addictions.” CNS Spectrums 11(12):924-30.
Bhattacharyya, S., D. E. Brown, J. A. Brewer, S. K. Vogt, and L. J. Muglia. (2007) “Glucocorticoid receptor regulates Toll-like receptor-4-mediated inflammatory responses by inhibition of p38 MAP kinase.” Blood 109(10): 4313- 9.
Brewer, J. A., J. E. Grant, and M. N. Potenza. (2008) “The Treatment of Pathological Gambling.” Addictive Disorders and Their Treatment 7(1): 1-13.
Brewer, J. A. and M. N. Potenza. (2008) “Impulse Control Disorders: Neurobiology and Genetics.” Biochemical Pharmacology 75: 63-75.
Ghaznavi, S., M. Nakic, P. Rao, J. A. Brewer, J. Hannestad, Z. Bhagwagar (2008) “Treatment options for patients with refractory schizophrenia following clozapine-induced neutropenia.” Am. J. Psychiatry (in press).
Brewer, J. A., P. D. Worhunsky, K. M. Carroll, B. J. Rounsaville, M. N. Potenza (2008) “Pre-Treatment Brain Activation During Stroop Task is Associated with Treatment Outcomes in Cocaine Dependent Patients.” Biological Psychiatry (in press).

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