Publications

Selected Papers

Boehmerle W, Splittgerber U, Lazarus MB, McKenzie KM, Johnston DG, Austin DJ, Ehrlich BE.

Paclitaxel induces calcium oscillations via an inositol 1,4,5-trisphosphate receptor and neuronal calcium sensor 1-dependent mechanism. Proc Natl Acad Sci U S A. 2006 Nov 28;103(48):18356-61. Epub 2006 Nov 17. [see PDF]

Estrada M, Varshney A, Ehrlich BE.

Elevated testosterone induces apoptosis in neuronal cells.
J Biol Chem. 2006 Sep 1;281(35):25492-501. [see PDF]

Schlecker C, Boehmerle W, Jeromin A, DeGray B, Varshney A, Sharma Y, Szigeti-Buck K, Ehrlich BE.

Neuronal calcium sensor-1 enhancement of InsP3 receptor activity is inhibited by therapeutic levels of lithium.
J Clin Invest. 2006 Jun;116(6):1668-74. [see PDF]

Gibson TB, Lawrence MC, Gibson CJ, Vanderbilt CA, McGlynn K, Arnette D, Chen W, Collins J, Naziruddin B, Levy MF, Ehrlich BE, Cobb MH.

Inhibition of glucose-stimulated activation of extracellular signal-regulated protein kinases 1 and 2 by epinephrine in pancreatic beta-cells.
Diabetes. 2006 Apr;55(4):1066-73. [see PDF]

Estrada M, Uhlen P, Ehrlich BE.

Ca2+ oscillations induced by testosterone enhance neurite outgrowth.
J Cell Sci. 2006 Feb 15;119(Pt 4):733-43. [see PDF]

Uhlen P, Burch PM, Zito CI, Estrada M, Ehrlich BE, Bennett AM.

Gain-of-function/Noonan syndrome SHP-2/Ptpn11 mutants enhance calcium oscillations and impair NFAT signaling.
Proc Natl Acad Sci U S A. 2006 Feb 14;103(7):2160-5. [see PDF]

Anyatonwu GI, Ehrlich BE.

Organic cation permeation through the channel formed by polycystin-2.
J Biol Chem. 2005 Aug 19;280(33):29488-93. [see PDF]

Zielinski CE, Jacob SN, Bouzahzah F, Ehrlich BE, Craft J.

Naive CD4+ T cells from lupus-prone Fas-intact MRL mice display TCR-mediated hyperproliferation due to intrinsic threshold defects in activation.
J Immunol. 2005 Apr 15;174(8):5100-9. [see PDF]

Jacob SN, Choe CU, Uhlen P, DeGray B, Yeckel MF, Ehrlich BE.

Signaling microdomains regulate inositol 1,4,5-trisphosphate-mediated intracellular calcium transients in cultured neurons.
J Neurosci. 2005 Mar 16;25(11):2853-64. [see PDF]

Choe CU, Harrison KD, Grant W, Ehrlich BE.

Functional coupling of chromogranin with the inositol 1,4,5-trisphosphate receptor shapes calcium signaling.
J Biol Chem. 2004 Aug 20;279(34):35551-6. [see PDF]

Johenning FW, Wenk MR, Uhlen P, Degray B, Lee E, De Camilli P, Ehrlich BE.

InsP3-mediated intracellular calcium signalling is altered by expression of synaptojanin-1.
Biochem J. 2004 Sep 1;382(Pt 2):687-94. [see PDF]

Cai Y, Anyatonwu G, Okuhara D, Lee KB, Yu Z, Onoe T, Mei CL, Qian Q, Geng L, Wiztgall R, Ehrlich BE, Somlo S.

Calcium dependence of polycystin-2 channel activity is modulated by phosphorylation at Ser812.
J Biol Chem. 2004 May 7;279(19):19987-95. [see PDF]

Thrower EC, Choe CU, So SH, Jeon SH, Ehrlich BE, Yoo SH.

A functional interaction between chromogranin B and the inositol 1,4,5-trisphosphate receptor/Ca2+ channel.
J Biol Chem. 2003 Dec 12;278(50):49699-706. [see PDF]

Anyatonwu GI, Buck ED, Ehrlich BE.

Methanethiosulfonate ethylammonium block of amine currents through the ryanodine receptor reveals single pore architecture.
J Biol Chem. 2003 Nov 14;278(46):45528-38. [see PDF]

Q-X. Jiang, E.C. Thrower, D.W. Chester, B.E. Ehrlich, and F. J. Sigworth.

Three-dimensional structure of type I inositol-1,4,5-triphosphate receptor at 24 Ǻ resolution.  EMBO
Journal 21:1-7 (2002). [see PDF]

Pusl, T., J.J. Wu, T.L. Zimmermann, L.,Zhang,  B.E. Ehrlich, J. B. Hoek, M. Berchtold, S. Karpen, M.H. Nathanson and A.M. Bennett.

EGF-mediated activation of the ETS-domain transcription factor Elk-1 requires nuclear Ca2+. 
Journal of Biological Chemistry 277:27517-27527 (2002). [see PDF]

Johenning, F.W., M. Zochowski, S.J. Conway, A.B. Holmes, P. Koulen, and B.E. Ehrlich.

Distinct intracellular calcium transients in neurites and somata integrate neuronal signals.
Journal of Neuruoscience 22:5344-5353 (2002). [see PDF]

O’Neill, A.F., R.E. Hagar, W.R. Zipfel, M.H. Nathanson, B.E. Ehrlich.

Regulation of the type III InsP₃ receptor by InsP₃ and calcium.
Biochemical and Biophysical Research Communications 294:719- 25 (2002). [see PDF]

Thrower, E.C., H.S. Park, S.H. So, S.H. Yoo, and B.E. Ehrlich.

Activation of the Inositol 1,4,5-Trisphosphate Receptor by the Calcium Storage Protein Chromogranin
A.  Journal of Biological Chemistry 277:15801-15806 (2002). [see PDF]

Koulen, P, Y. Cai, L. Geng, Y. Maeda, R. Witzgall, B.E. Ehrlich, S. Somlo.

Polycystin-2 functions as an intracellular calcium release channel.
Nature Cell Biology 4:191-197 (2002). [see PDF]

Koulen, P., T. Janowitz, F. Johenning, B.E. Ehrlich. 

Characterization of the ryanodine receptor from Zebrafish.
Journal of Membrane Biology. 183:155-163 (2001). [see PDF]

Hagar, R.E. and B.E. Ehrlich. 

Regulation of the type lll InsP3 receptor by InsP3 and ATP. 
Biophysical Journal 79: 271-278 (2000). [see PDF]

Koulen, P and B.E. Ehrlich. 

Reversible block of the calcium release channel/ryanodine receptor by protamine, a heparin antidote. 
Molecular Biology of the Cell 11: 2213-2219 (2000). [see PDF]

Kaftan, E.J., B.E. Ehrlich, J. Watras. 

Inositol (1,4,5)-trisphosphate (InsP₃) and calcium interact to increase the dynamic range of InsP₃ receptor-dependent calcium signaling. 
Journal of General Physiology 110: 529-538 (1997). [see PDF ]

Reviews

Choe Cu, Ehrlich BE

The Inositol 1,4,5-trisphosphate receptor (IP3R) and its regulators: sometimes good and sometimes bad teamwork.
Sci STKE. 2006 Nov 28;2006(363):re15. [see PDF]

Minagawa N, Ehrlich BE, Nathanson MH.

Calcium signaling in cholangiocytes.
World J Gastroenterol. 2006 Jun 14;12(22):3466-70.

Anyatonwu GI, Ehrlich BE.

Calcium signaling and polycystin-2.
Biochem Biophys Res Commun. 2004 Oct 1;322(4):1364-73.

Hagar, R.E. and B.E. Ehrlich.

Regulation of the type III InsP₃ receptor and its role in beta cell function.
Cellular and Molecular Life Sciences. 57:1938-49 (2000). [see PDF]

Somlo, S and B.E. Ehrlich.

And now for something completely different:  Defective channel proteins cause kidney disease. 
Current Biology 11:R356-60 (2001). [see PDF]

Thrower, E.C, Hagar, R.E. and B.E. Ehrlich.

Channel properties of InsP₃ receptor isoforms.
Trends in Pharmacological Sciences. 22:580-586 (2001). [see PDF]

Johenning, F.W. and B. E. Ehrlich. 

Signaling microdomains: InsP3 receptor localization takes on new meaning. 
Neuron 34:173-175 (2002). [see PDF]

See the complete list of Dr. B.E. Ehrlich’s papers on her Curriculum Vitae .