Research Interests:
My laboratory is interested in how cells regulate their intracellular calcium concentration. We have focussed on one aspect of this process, the release of calcium from intracellular stores. We study the two classes of calcium release channels known to exist inside virtually all cells - the InsP3-gated channel and the ryanodine receptor/channel - and we have identified a new intracellular calcium release pathway. Our goal is to understand how the function of these channels are regulated by processes within the cell. These data will form the background for our long-term interest, how calcium release channel function is altered in disease. For example, a binding protein for immunosuppressive drugs is associated with these channels. We hypothesize that some side effects of immunosuppressive therapy (eg., neurological seizures and heart failure) are related to drug-induced functional changes in channel activity. Our studies will test our hypotheses and hopefully, will lead to suitable treatment regimens.

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