Ying Xia, M.D.,Ph.D.
Associate Professor

















Mailing Address:

Yale University School of Medicine
LMP Bldg - Rm 3107
333 Cedar Street (POB 208064)
New Haven, Connecticut 06520
United States


Contact Information:

Office Phone: (203) 785-6101
Lab Phone: (203) 737-1404; (203) 737-4192; (203) 785-6793; (203) 785-7860; (203) 737-1252
Fax: (203) 785-6337
E-Mail: ying.xia@yale.edu


Xia Lab Homepage

Ying Xia Laboratory


Education:

Medical Student, Suzhou Medical College, China, 1977
Master of Medicine, Shanghai Medical University, China, 1983
Doctor of Medicine (Ph.D.), Shanghai Medical University, China, 1987
Fellowship, Yale University School of Medicine, USA, 1993


Previous Positions:

1977-1979, Resident Physician, Internal Medicine, Changzhou, China
1979-1980, Certified Physician, Internal Medicine, Changzhou, China
1987-1988, Lecturer, Neuroscience, Shanghai Medical University, China
1993-1998, Associate Research Scientist, Pediatrics, Yale University School of Medicine, USA
1998-2002, Research Scientist, Pediatrics, Yale University School of Medicine, USA
2002-present, Associate Professor, Pediatrics, Yale University School of Medicine, USA


Research Interests:

Ying Xia studies molecular and developmental neuroscience, particularly the cellular mechanisms for neuronal excitability during hypoxia and new strategies for neuroprotection from hypoxic/ischemic injury with molecular, transgenic and electrophysiological techniques. In addition, his laboratory is collaborating with Chinese scientists to study the effects of acupuncture on neurological diseases. Currently, there are 4 ongoing projects in Xia Laboratory: 1) Hypoxia and neuronal excitability: cellular mechanisms; 2) Neuronal protection from hypoxic/ischemic injury; 3) regulation of ionic transporters and exchangers during development and in hypoxia/ischemia; and 4) Effects of acupuncture on cerebral ischemia and epilepsy.


Funding Received (in last 5 years):

2002-2008, PI, R01 Research Grant from National Institute of Health, USA.
2002-2005, PI, R21 Research Grant from National Institute of Health, USA.
1999-2002, PI, Research Grant from March of Dimes Birth Defects Foundation, USA.
1997-2002, PI, R01 Research Grant from National Institutes of Health, USA.


Publications (in last 5 years):

  1. Xia Y, Fung ML, O'Reilly J and Haddad GG. Increased neuronal excitability after long term O2 deprivation is mediated mainly by sodium channels. Mol Brain Res, 76: 211-219, 2000.
  2. Banasiak KJ, Xia Y and Haddad GG. Mechanisms underlying hypoxia-induced neuronal apoptosis. Prog Neurobiol, 62: 215-249, 2000.
  3. Zhang J, Haddad GG and Xia Y. Delta-, But not mu- and kappa-, opioid receptor activation protects neocortical neurons from glutamate-induced excitotoxic injury. Brain Res, 885: 143-153, 2000.
  4. Bhandari A, Xia Y, Cortright R, Dohm GL and Bazzy AR. Effect of respiratory muscle training on GLUT-4 in the sheep diaphragm. Medicine & Science in Sports & Exercise, 32: 1406-1411, 2000.
  5. Douglas RM, Schmitt BM, Xia Y, Bevensee MO, Biemesderfer D, Boron WF and Haddad GG. Sodium-hydrogen exchangers and sodium-bicarbonate cotransporters: Ontogeny of protein expression in the rat brain. Neuroscience, 102: 217-228, 2001.
  6. Xia Y and Haddad GG. Major difference in the expression of delta- and mu-opioid receptors between turtle and rat brain. J Comp Neurol, 436: 202-210, 2001.
  7. Zhang JH, Gibney GT and Xia Y. Effect of prolonged hypoxia on expression of Na+ channel mRNA subtypes in the developing rat cortex. Mol Brain Res, 91: 154-158, 2001.
  8. Gibney GT, Zhang JH, Douglas RM, Haddad GG and Xia Y. Na+-Ca2+ exchanger expression in the developing rat cortex. Neuroscience, 112: 65-73, 2002.
  9. Zhang JH, Gibney GT and Xia Y. Neuroprotective role of delta-opioid receptors in cortical neurons. Am J Physiol (Cell Physiol) 282: C1225-1234, 2002.
  10. Xia Y, Zhao P, Xue J, Gu XQ, Sun XL, Yao H and Haddad GG. Na+ channel expression and neuronal function in Na+/H+ exchanger 1 null mutant mouse. J Neurophysiol, 89: 229-236, 2003.
  11. Hong S, Gibney GT, Esquilin M, Yu J, and Xia Y . The role of protein kinases in neuronal regulation of lactate dehydrogenase activity during hypoxia. Brain Res 1009: 195-202, 2004.
  12. Xia Y , Guo GC and Cheng JS. Acupuncture and Brain Protection from ischemia: the Role of delta-opioid receptors. Theses of 5th International Symposium on Clinical and Academic Research of Acupuncture & Moxibustion in Shangahi. Pages 297-298, 2004.
  13. Zhao P, Xue J, Gu XQ, Haddad GG and Xia Y . Intermittent hypoxia modulates Na+ channel expression in developing mouse brain. Int J Dev Neurosci, 23: 327-33, 2005.
  14. Zhao P, Ma MC, Qian H and Xia Y . Decreased Density of Delta-Opioid Receptors in Na+/H+ Exchanger 1 Null Mutant Mouse Brain with Epilepsy. Neurosci Res, 53: 442-446, 2005.
  15. Chen Z, Fadiel A, Naftolin F, Eichenbaum KD, Xia Y . Circulation DNA: Biological implications for cancer metastasis and immunology. Med Hypotheses, 65: 956-961, 2005.
  16. Zhao P, Qian H and Xia Y . GABA and glycine are protective to mature and toxic to immature in cortical neurons under hypoxia. Eur J Neurosci 22: 289-3000, 2005.
  17. Ma MC, Qian H, Ghassemi F, Zhao P and Xia Y . Oxygen sensitive delta-opioid receptor-regulated survival and death signals: Novel insights into neuronal preconditioning and protection. J Biol Chem, 280: 16208-16218, 2005.
  18. Chen Z, Fadiel A and Xia Y. Functional duality of Merlin: A conundrum in proteome complexity. Med Hypotheses, 67:1095-1098, 2006.
  19. Zhang J, Qian H, Zhao P, Hong SS and Xia Y . Rapid hypoxia preconditioning protects cortical neurons from glutamate Toxicity Through delta-Opioid Receptor. Stroke, 37: 1094-1099, 2006.
  20. Chao D, Donnelly D, Feng Y, Bazzy-Asaad A, Xia Y. Cortical delta-opioid receptors potentiate K+ homeostasis during anoxia and oxygen-glucose deprivation. J Cereb Blood Flow Metab, in press.
  21. Soon-Sun Hong, Hong Qian, Peng Zhao, Alia Bazzy-Asaad and Ying Xia. Effect of anisomycin on neuronal injury induced by delta-opioid receptor inactivation in cortical neurons. Brain Res, in press.
  22. Chao DM, Bazzy-Asaad A, Gianfranco B and Xia Y. Delta-, but not mu-, opioid receptor stabilizes K+ homeostasis by reducing Ca2+ influx in the cortex during acute hypoxia. J Cell Physiol, in press.


Recent Work (Recent Manuscripts & Conference Abstracts):

  1. Zhao P, Guo JC, Xia Y, Hong SS, Bazzy-Asaad A, Cheng JS and Xia Y . Electro-acupuncture and brain protection from cerebral ischemia: The role of delta-opioid receptor. Presented at 32nd Annual Meeting of Society for Neuroscience, 2002.
  2. Qian H and Xia Y . Hypoxia and Na+ channel expression in cultured cortical neurons: up-regulation in the immature but down-regulation in the mature. 33rd Annual Meeting of Society for Neuroscience, 2003.
  3. Guo JC, Cheng JS, Banasiak KJ, Zhu JM and Xia Y . Electro-acupuncture points and brain protection from ischemic injury. Presented at 33rd Annual Meeting of Society for Neuroscience, 2003.
  4. Qian H, Ma MC and Xia Y. Differential expression of NMDA receptor in developing neurons during acute and chronic hypoxia. Presented at the 34th annual meeting of Society for Neuroscience, 2004.
  5. Ma MC, Donnelly DF and Xia Y. Neuronal preconditioning inhibits hypoxia-induced sodium channel up-regulation cia delta-opioid receptors. Presented at the 34th annual meeting of Society for Neuroscience, 2004.
  6. Qian H, Banasiak K, Zhao P and Xia Y. Effects of inhibitory neurotransmitters on GABA and glycine receptor expression: Age-difference in cortical neurons under hypoxia. Presented at the 35th annual meeting of Society for Neuroscience, 2005.
  7. Chao D, Qian H, Ghassemi F, Chen JS and Xia Y. Transgenic over-expression of elta-opioid receptors protects the cortex from anoxic of disruption of ionic homeostasis. 36th annual meeting of Society for Neuroscience, 2006.
  8. Zhou F, Guo J, Yang R, Cheng IS, Wu GC, and Xia Y. Electro-acupuncture increases cerebral blood flow and protects the rat brain from ischemic injury. World Stress Congress, 2007.
  9. Zhou F, Guo J, Cheng IS, Wu GC, and Xia Y. Electro-acupuncture and brain protection from cerebral ischemia: Differential roles of acupoints. World Stress Congress, 2007.
  10. Zhou F, Guo J, Cheng IS, Wu GC, and Xia Y. Electro-acupuncture induced protection from cerebral ischemia is dependent on stimulation intensity and frequency. World Stress Congress, 2007.