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Reproductive Immunology Unit
Department of
Obstetrics, Gynecology
& Reproductive Sciences
333 Cedar Street
New Haven CT, 06510
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Immune System and the Brain
Estrogen,
microglia and the IBB The microglial-cytokine--estrogen mediated network
is described as a major player in the brain including the Immune Brain
Barrier. One of the functional areas involved maybe the role that
microglia could play in synaptic plasticity. The cellular proximity,
presence of receptor-ligand interactions and biochemical signaling
coincident with microglial action on synaptic integrity strongly suggest
that is the case. The proof of estrogenās ability to regulate this
network will enhance the role of the microglia as important regulators
of physiological synaptic homeostasis.
| The
laboratory is interested in: |
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The
role of the Fas/FasL system in the regulation of the immune
response in the Central Nervous System and the existence of
an Immune Brain Barrier. |
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The
role of macroglia as a regulatory cell affecting immune and
non-immune responses in the brain. |
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Effect
of estrogens on neuronal cell growth and proliferation and cytokine
production by microglia. |
| Expression
of FasL in the rat brain. |
| Full
text |
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| Estrogen
and Microglia in the brain. |
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text |
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| Estrogen-Regulated
Developmental Neuronal Apoptosis is Determined by Estrogen Receptor
Subtype and the Fas/Fas Ligand System. |
| Full
text |
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