CURRICULUM VITAE

Yale University School of Medicine

 

 

Name: Ronald F. Feinberg, M.D., Ph.D.

Faculty Appointment: Associate Professor - Adjunct

School Assignment: School of Medicine

Born: July 28, 1957; Philadelphia, PA

Education: 1974-77 LaSalle College

Philadelphia, PA

B.A. Maxima Cum Laude, Biology

1977-83 University of Pennsylvania Medical Center Philadelphia, PA

M.D. awarded concomitantly with

Ph.D. in Biochemistry

Career: 1983-84 Intern, Obstetrics and Gynecology

Yale-New Haven Hospital, New Haven, CT

1984-87 Resident, Obstetrics and Gynecology

Yale-New Haven Hospital, New Haven, CT

1994-95 Fellow, Reproductive Endocrinology and Infertility

University of Pennsylvania Medical Center, Philadelphia, PA

      1. Assistant Professor, Standing Faculty

Department of Obstetrics and Gynecology

University of Pennsylvania Medical Center, Philadelphia, PA

      1. Attending Staff Physician
      2. Department of Obstetrics and Gynecology

University of Pennsylvania Medical Center, Philadelphia, PA

1995-97 Director, Pregnancy Loss Evaluation Program

Division of Human Reproduction

Department of Obstetrics and Gynecology

University of Pennsylvania Medical Center, Philadelphia, PA

      1. Assistant Clinical Professor

Department of Obstetrics and Gynecology

Yale University School of Medicine, New Haven, CT

    1. Attending Staff Physician

Department of Obstetrics and Gynecology

Christiana Care Health System, Newark, DE

1997- Medical Director, In Vitro Fertilization (IVF) Program

Reproductive Associates of Delaware

Wilmington, DE

Professional Honors or Recognition:

Awarded 5 U.S. Patent Inventions, with Dr. Harvey Kliman as Co-Inventor:

Patent No. 5,276,017: "Therapeutic and diagnostic applications of tropho-uteronectin (TUN) manipulation" Awarded January 4, 1994.

Patent No. 5,395,825: "Fertility regulation with transforming growth factor beta (TGFß)" Awarded March 7, 1995.

Patent No. 5,523,229: "Antibodies specific for oncofetal fibronectin" Awarded June 4, 1996.

Patent No. 5,599,680: "Diagnostic applications of mouse ascites golgi (MAG) manipulation" Awarded February 4, 1997.

Patent No. 5,693,479: "Fertility determination with transforming growth factor beta (TGFß)" Awarded December 2, 1997.

 

Grants (All as Principal Investigator):

1994-99 National Institute of Health 1R29HD29729: "Tropho-uteronectin (TUN) Function and Regulation"; IRG recommended full 5 year funding of $572,250 ($70,000 direct costs/year; 50% effort)

1994-95 University of Pennsylvania Research Foundation: "Oncofetal Fibronectin and Ovarian Cancer" ($25,000 awarded in direct costs; one year grant)

1993-94 Adeza Biomedical Sponsored Research and Patent Licensing Agreement with University of PA: "Human Trophoblasts and Characterization of Trophoblast Fibronectin (TUN)" ($63,300 awarded in direct costs; one year grant)

1991-93 March of Dimes Basic Research Grant #91-0163: "Human Trophoblast-Extracellular Matrix Interactions" ($60,000 awarded in direct costs; two year grant)

1991-92 Ares-Serono Sponsored Research Agreement: "Tropho-uteronectin (TUN) Purification and Characterization" ($50,000 awarded in direct costs; one year grant)

1991-92 University of Pennsylvania Research Foundation: "Tropho-uteronectin (TUN) and Normal Pregnancy Implantation" ($18,000 awarded in direct costs; one year grant)

1990-91 University of Pennsylvania Research Foundation and Biomedical Research Support Grant: "Is Oncofetal Fibronectin a Trophoblast "Glue" for Normal Human Implantation?" ($17,000 awarded in direct costs; one year grant)

1988-91 March of Dimes Basil O'Connor Award #5-672: "Human Trophoblast Regulation of Plasminogen Activators and Plasminogen Activator Inhibitors: A Potential Role in Abnormal Pregnancy States." ($70,000 awarded in direct costs; two year grant)

Professional Service:

Fellow, American College of Obstetricians and Gynecologists

Member, American Society for Reproductive Medicine

Associate Member, Society for Gynecologic Investigation

Ad hoc reviewer, Reproductive Biology Study Section, National Institutes of Health

 

Bibliography:

Original Articles

  1. Brodsky L.H., Feinberg R.F., Sorof S. (1978) "Carcinogen-protein complexes in hamster colon and glandular stomach during long-term administration of 3-methylcholanthrene," Cancer Research 38: 1654-1660.
  • Feinberg R.F., Sun L.K., Ordahl C.P., Frankel F.R. (1983) "Identification of glucocorticoid-induced genes in rat hepatoma cells by isolation of cloned cDNA sequences," Proc. Natl. Acad. Sci. USA. 80: 5042-5046.
  • Lockwood C.J., Romero R., Feinberg R.F., Clyne L.P., Coster B., Hobbins J.C. (1989) "The Prevalence and Biological Significance of Lupus Anticoagulant and Anticardiolipin Antibodies in a General Obstetrics Population," Am. Journal of Obstetrics and Gynecology 161:369-373.
  • Feinberg R.F., Kao L.-C., Haimowitz J.E., Queenan J.T., Wun T.-C., Strauss J.F.III, Kliman, H.J. (1989): "Plasminogen Activator Inhibitors Types 1 and 2 in Human Trophoblasts: PAI-1 is a Marker of Invading Trophoblasts," Lab.Invest. 61:20-26.
  • Kliman H.J , Feinberg R.F., Haimowitz J.E. (1990) "Interactions between human trophoblasts & endometrium in an in vitro suspension culture system," Placenta 11:349-67
  • Kliman H.J. and Feinberg R.F. (1990) "Human trophoblast-extracellular matrix (ecm) interactions in vitro: ecm thickness modulates morphology and proteolytic activity," Proc. Natl. Acad. Sci. USA 87: 3057-3061.
  • Kliman H.J., Feinberg, R.F., Haimowitz J.E. (1990) " Interactions between human term trophoblasts and endometrium in vitro," Colloques INSERM 199: 3-9.
  • Feinberg R.F., Kliman H.J. and Cohen A.W. (1991) "Pre-eclampsia, trisomy 13, and the placental bed," Obstetrics and Gynecology 78: 505-508.
  • Feinberg R.F., Kliman H.J. and Lockwood C.J. (1991) "Is oncofetal fibronectin a trophoblast glue for human implantation?" American Journal of Pathology 138: 537-543. Cited in 1992 Yearbook of Obstetrics and Gynecology.
  • Feinberg R.F. and Kliman H.J. (1992) "‘Fetal’ fibronectin and preterm labor" Published letter to the editor. New England Journal of Medicine: 326 (Mar 5): 708.
  • Feinberg R.F. and Kliman, H.J. (1993) "Tropho-uteronectin (TUN): A unique oncofetal fibronectin deposited in the extracellular matrix of the tropho-uterine junction and regulated in vitro by cultured human trophoblasts" Trophoblast Research 7: 167-179.
  • Feinberg R.F., Kliman H.J., Wang C.-L. (1994) "Transforming growth factor beta (TGFß) stimulates trophoblast oncofetal fibronectin synthesis in vitro: Implications for trophoblast implantation in vivo" Journal of Clinical Endocrinology &Metabolism 78: 1241-1248.
  • Feinberg R.F. and Wang C.-L. (1994) "Monoclonal antibody FDC-6 exhibits binding to human plasma fibronectin: A caveat for cervicovaginal oncofetal fibronectin testing?"Am. Journal of Obstetrics and Gynecology 171: 1302-1309. Cited in 1995 Yearbook of Obstetrics and Gynecology.
  • Feinberg R.F., Kliman H.J., Bedian V., Monzon-Bordonaba, F., Menzin A., Wang C.-L. (1995) "Monoclonal antibody X18A4 identifies an oncofetal fibronectin epitope distinct from the FDC-6 binding site"Am. Journal of Obstetrics and Gynecology 172: 1526-36.
  • Kliman H.J., Feinberg R.F., Schwartz L.B., Feinman M.A., Lavi E., Meaddough, E.L. (1995) "A human endometrial mucin identified by MAG (mouse ascites Golgi) antibodies: menstrual cycle-dependent localization suggests a link to early implantation events." Am. Journal of Pathology, 146: 166-181.
  • Feinberg R.F. (1995) "First-trimester versus term trophoblast cultures: Can we learn about implantation from both?" Published letter to the editor. Am. Journal of Obstetrics and Gynecology 172: 1939.
  • Turpeenniemi-Hujanen T., Feinberg R.F., Kauppila A., Puistola U. (1995) "Extracellular matrix interactions in early human embryos: Implications for normal implantation events." Fertility and Sterility 64: 132-138.
  • Nachtigall M.J., Kliman H.J., Feinberg R.F., Olive D.L., Engin O., Arici A. (1996) "The effect of leukemia inhibitory factor (LIF) on trophoblast differentiation: A potential role in human implantation." Journal of Clinical Endocrinology & Metabolism 81: 801-806.
  • Monzon-Bordonaba, F., Wang, C.-L., Feinberg R.F. (1997) "‘Fibronectinase’ activity in cultured human trophoblasts is mediated by urokinase-type plasminogen activator." Am. Journal of Obstetrics and Gynecology 176:58-65.
  • Sawin S.W., Loret de Mola J. R., Monzon-Bordonaba F., Wang C.-L., Feinberg R.F. (1997) "Hydrosalpinx fluid stimulates trophoblast oncofetal fibronectin production: implications for embryonic implantation in assisted reproduction." Fertility and Sterility 68: 65-71.
  • Menzin A.W., Loret de Mola, J.R., Bilker W.B., Wheeler J.E., Rubin S.C., Feinberg R.F. (1998) "Identification of oncofetal fibronectin in patients with advanced epithelial ovarian cancer: detection in ascitic fluid and localization to primary sites and metastatic implants." Cancer 82: 152-158.
  • Bell K.A., Van Deerlin P., Haddad B., Feinberg R.F. (1999) "The cytogenetic diagnosis of a normal 46,XX karyotype in spontaneous abortion specimens is frequently incorrect." Fertility and Sterility, in press.

    Case Reports
    1. Feinberg R.F., Lockwood C.J., Salafia C., Hobbins J.C. (1988) "Sonographic Diagnosis of a Pregnancy with a Diffuse Hydatidiform Mole and Coexistent 46,XX Fetus," Obstetrics and Gynecology 72: 485-488.

    Review Papers and Chapters

    1. Coutifaris C., Babalola G.O., Feinberg R.F., Kao L.-C., Kliman H.J., Strauss J.F. III. Purified human cytotrophoblasts: Surrogates for the blastocysts in in vitro models of implantation. In: Proceedings of the VI World Congress on In Vitro Fertilization and Alternate Assisted Reproduction, Z. Ben-Rafael and N. Laufer (Eds.), Plenum Publishing Co, New York, 1989.
    2. Kliman H.J., Coutifaris C., Babalola G.O., Soto E.A., Kao L.-C., Queenan J.T., Feinberg R.F., Strauss J.F. III. (1989) "The human trophoblast: Homotypic and heterotypic cell-cell interactions," Prog. Clin. Biol. Res. 294: 425-34.
    3. Kliman H.J., Coutifaris C., Feinberg R.F., Strauss J.F. III, Haimowitz J.E. Implantation: In vitro human models utilizing human tissues. In: Blastocyst Implantation. K. Yoshinaga (ed), Serono Symposia, 1989.
    4. Kliman H.J. and Feinberg R.F. Differentiation of the Trophoblast. In: The First Twelve Weeks. J. Hustin, E. Jauniaux, ER Barnea (eds), Springer-Verlag Publishers, 1992.
    5. Feinberg R.F., Kliman H.J. and Wang C.-L. Tropho-uteronectin (TUN): A Fibronectin Marker of Trophoblast Attachment and Differentiation in vivo and in vitro. In: Local Systems in Reproduction. F. Naftolin and R. Magness (ed), Serono Symposia, 1992.
    6. Feinberg R.F. and Kliman H.J. Human Trophoblasts and Tropho-uteronectin (TUN): A Model for Studying Early Implantation Events. Assisted Reproduction Rev 3: 19-25, 1993.
    7. Dunn P.A. and Feinberg R.F. Oncofetal Fibronectin: New Insight into the Physiology of Implantation and Labor. Journal of Obstetric, Gynecologic, and Neonatal Nursing, 1996.
    8. Timbers K.A. and Feinberg R.F., Recurrent pregnancy loss: A review. Nurse Practitioner Forum 7: 64-75, 1996.
    9. Feinberg R.F. and Kliman H.J. MAG (Mouse Ascites Golgi) Mucin in the Endometrium: A Potential Marker of Endometrial Receptivity to Implantation". In. The Endometrium and Endometriosis. M. Diamond and K. Osteen (eds), Blackwell Science Publishers, 1997.
    10. Feinberg R.F. and Sciscione A. (1998) Early Recurrent Pregnancy Loss: A Board Review Manual, Hospital Physician.