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Yale/NIDA
Proteomics Center
Yale University
300 George Street
New Haven, CT 06511
Contact Us
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NIDA Proteomics Center
> Fact Sheet
Yale/NIDA Neuroproteomics Center
Fact Sheet
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Title of Center Grant: |
Yale/NIDA Neuroproteomics
Research Center |
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Grant Number: |
1 P30 DA018343-01 |
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Theme of Center: |
"Proteomics of Altered
Signaling in Addiction" |
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Principal Investigator: |
Kenneth R. Williams, Ph.D.
Director, W.M. Keck Foundation
Biotechnology Resource Laboratory
Professor (Adj,) Research
Dept. of Molecular Biophysics & Biochemistry
Yale University School of Medicine |
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Co-Principal Investigator: |
Angus C. Nairn, Ph.D.
Professor, Department of Psychiatry
Yale University School of Medicine |
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Awarding Agency: |
National Institute on Drug
Abuse (NIDA)
National Institutes of Health (NIH) |
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#Grants Awarded: |
2 |
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Total Funding Awarded to Yale: |
$7.7 million |
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Total Budget Period: |
8/23/2004 – 5/31/2009 |
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Center Cores: |
Administrative, Bioinformatics
and Biostatistics, Protein Identification, Protein Microarray; and Protein
and Lipid Separation and Profiling |
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Center Investigators: |
14 from Yale University, the
Veterans Administration Medical Center (West Haven, CT) and Rockefeller
University |
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Specific Aims: |
- Bring together Yale faculty working at
the forefront of such key neuroscience areas as signal transduction,
plasticity, neuronal morphogenesis, lipid metabolism in neuronal signaling
and synaptic function, and response to psychotropic drugs with experts in
proteomics, biostatistics, and bioinformatics.
- Apply high-throughput, state-of-the-art
proteomic technologies like MALDI-MS based biomarker analysis,
two-dimensional chromatography, differential (fluorescence) gel
electrophoresis (DIGE), isotope-coded affinity tag (ICAT), and antibody
microarrays to analyze adaptive changes in neuronal protein expression and
regulation that occur in response to drugs of abuse.
- To advance and develop new separation
tools for cellular lipids and neuroproteomic technologies for studying the
brain phosphoproteome and apply these to studies of the actions of drugs
of abuse.
- Analyze the actions of opiates; the
psychostimulants, cocaine and amphetamine; and nicotine on protein
expression.
- Study the proteomic changes that occur
both pre- and post-synaptically following the actions of drugs of abuse.
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Overall Goal: |
To substantially increase
understanding of the biochemical mechanisms that underlie substance abuse
and its treatment. |
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