Site Index:

NHLBI Proteomics Center >  Research Projects

Listing of Research Projects Supported by
the Yale/NHLBI Proteomics Center

1. Protein and Phosphoprotein Profiling: Team Leader, K. Williams (Mol. Biophys. & Biochem.)

   1. Development of protein and phosphoprotein profiling technology: K. Stone, W. McMurray and K. Williams (Mol. Biophys. & Biochem.)

   2. Engineering RNA molecular switches that respond to protein targets. R. Breaker (Molecular, Cellular & Developmental Biology)

   3. Biostatistics and Bioinformatics: Group Leader, P. Miller (Medical Informatics)

      1. Quality control, quality assurance, and statistical analysis of protein expression data, H. Zhao (Epidemiology and Public Health)

      2. NHLBI/Yale Expression Database (YED): an interoperable protein and mRNA expression database, K. Cheung (Medical Informatics)

      3. Functional and Interrelative Proteomics, M. Gerstein (Mol. Biophysics & Biochem.)

   4. Global Proteomic Approaches to Hematopoietic Differentiation: Group Leader, S. Weissman (Genetics)

      1. Molecular and functional analysis of myeloid differentiation, S. Weissman (Genetics)

      2. Molecular and functional correlates of myelodysplasia, N. Berliner (Medicine)

      3. Downstream targets of the homeodomain gene Pitx2 in hematopoietic cells, B. Forget (Medicine)

      4. Differential protein expression during early hematopoietic differentiation and mobilization, D. Krause (Laboratory Medicine)

      5. Characterization of Evi-1-induced changes in protein expression during myelopoiesis, A. Perkins (Pathology)

   5. Hypertension

      1. Characterization of a regulated paracellular conductance involved in hypertension, R. Lifton (Chair, Genetics)

   6. Vascular Biology

      1. a. Protein expression profiling and phosphoproteome analysis of lipid rafts during angiogenesis, W. Sessa (Pharmacology)

      2. b. Integrin engagement-mediated alterations in T cell HuR protein:protein interactions and posttranslational modifications, J. Bender (Internal Medicine)

2. Development of Cell-Permeable, Synthetic Biotechnologies for Blocking Specific Protein: Protein and Protein Post-Translational Modifications: Team Leader, W. Sessa (Pharmacology)

   1. Design of organelle-specific peptides for therapeutic disruption of protein-protein interactions, W. Sessa (Pharmacology)

   2. Intracellular delivery of peptides, proteins, and nucleic acids for studying cellular function, D. Ward (Genetics)

   3. Development of new technology to discover peptides that reduce inflammation, S. Ghosh (Immunobiology)

   4. Protein-based vascular addressing and targeted cellular internalization, F. Giordano (Internal Medicine)

   5. Development of cell permeable miniature proteins as highly selective antagonists of protein-protein complexation in vivo, A. Schepartz (Chemistry)

   6. Utility of cell permeable peptides to inhibit intracellular trafficking of signaling and adhesion molecules in vascular endothelial cells, J. Pober (Pathology)

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Comments or suggestions to Greg Blasko.

Last modified: 27-Mar-2006 (GB)