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Yale/NHLBI
Proteomics Center
Yale University
300 George Street
New Haven, CT 06511
Contact Us
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NHLBI Proteomics Center
> Fact Sheet
Fact Sheet for the Yale/NHLBI Proteomics
Center Contract
| Title of
Contract: |
NHLBI Proteomics Center at
Yale University |
| Contract
Number: |
N01-HV-28186 |
| Principal
Investigator: |
Kenneth R. Williams, Ph.D.
Director, Keck Laboratory
Professor (Adj,) Research
Dept. of Molecular Biophysics & Biochemistry |
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Co-Investigator: |
William C. Sessa, Ph.D.
Director, Vascular Cell Signaling & Therapeutics Program
Professor, Department of Pharmacology |
| Awarding
Agency: |
National Heart, Lung, Blood
Institute (NHLBI)
National Institutes of Health (NIH) |
| #Contracts
Awarded: |
10 Nationally |
| NIH/NHLBI
Press Release: |
http://www.nhlbi.nih.gov/new/press/02-10-09.htm |
Total Funding
Awarded
to Yale: |
$18.2 million dollars |
| Total Budget
Period: |
10/2002 - 9/2009 |
| #Key
Personnel: |
23 Including 21 faculty from
12 Yale Departments |
| #Staff: |
47 Corresponding to 20 FTE
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| Specific Aims: |
- Improve and develop new protein
profiling biotechnologies to identify proteins that play key roles and/or
serve as biomarkers for diseases related to vascular biology,
hematopoiesis, and blood pressure regulation.
- Design cell permeable, synthetic
peptide-based reagents to block protein:protein interactions of key
proteins involved in these disease processes in cells and tissues of
interest.
- Utilize protein profiling to monitor the
impact of blocking key protein:protein interactions in vivo.
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| Overall Goal: |
Increase our understanding of
atherosclerosis, inflammation, blood diseases, myelodysplasia, resistance to
chemotherapy, and immunological rejection of transplanted tissues and organs
which should lead to more effective disease treatments. |
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