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NHLBI Proteomics Center
> Description & History
Description and History of the NHLBI/Yale
Proteomics Center The
Yale/NHLBI Proteomics Center was created on October 1, 2002 by the awarding of
one of 10 NHLBI
contracts to Yale University. This award and the Center will have a very
positive impact on Yale University and will build on
the considerable and highly complementary expertise of 21 Yale
faculty in 12 departments and of the
W.M. Keck Laboratory
at Yale University, which is one of the largest academic laboratories of its
kind in the world. The Proteomics Center thus will be supported by
state-of-the-art mass spectrometry, protein profiling, and peptide synthesis
biotechnology expertise as well as by instrumentation in the Keck Laboratory. A
unique feature of the Center is that it will bring together faculty with highly
regarded research programs in vascular biology, hematopoiesis, and hypertension
with faculty who are leaders in designing the cell permeable synthetic
biomolecule delivery systems that hold enormous promise for developing entirely
new strategies for disease treatment. In addition, the Center will be further
supported by faculty who are developing new approaches to the study of
proteomics and who are experts in building the databases needed to effectively
analyze, archive, and interpret the enormous amounts of protein expression data
that will be produced by this research.
Major goals of the proposed Center research are to
improve existing and develop new:
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biotechnologies to identify
proteins that play key roles in diseases related to vascular biology,
hematopoiesis, and blood pressure regulation.
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synthetic peptide-based reagents
to specifically modulate the activities of these key proteins in cells and
tissues.
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approaches to diagnose, more
accurately classify, and more effectively treat diseases such as
atherosclerosis, inflammation, blood diseases, myelodysplasia and to better
understand resistance to chemotherapy, and immunological rejection of
transplanted tissues and organs.
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