Yale School of Medicine

Neurosurgery

Williamson Research, Neurosurgery

Williamson Research, Neurosurgery

Neurosurgery
P.O., Box 208082
New Haven, CT 06520-8082
Tel: 203.785.2805
Fax: 203.785.6916
neurosurgery@yale.edu

Williamson Research

My lab is interested in the circuit and cellular changes associated with the development of the chronic state in humans and in animal models of temporal lobe epilepsy. We use a variety of electrophysiological and anatomical techniques including whole cell patch clamp in brain slices and cell fills to examine these issues.

While many animal models of epilepsy have been developed, it is important to have a thorough understanding of the human pathology so that the models can be evaluated. We have the opportunity to examine human material resected for the treatment of medically intractable seizures and found that in there are numerous changes in the network properties in one part of the hippocampus, the dentate gyrus. We have primarily focused on alterations in the inhibitory system and have described several changes in both the inhibitory circuitry as well as in the regulation of the availability of GABA, the primary inhibitory transmitter in the central nervous system. Many of these changes also occur in an animal model of temporal lobe epilepsy, the kainate-treated rat, and we are currently studying them in greater detail.

In addition to the studies examining circuit changes in chronically epileptic tissue, we are interested in the role non-synaptic mechanisms can play in the regulation of neuronal excitability in both control and epileptic tissue and in how abnormal synaptic activity can be regulated by neuromodulators including peptides and ligands for a variety of receptors. As part of this effort, we are examining synaptic plasticity in the human material with an eye to examining the link between alterations in synaptic function and brain function.

I work primarily with Dr. Peter Patrylo, an Associate Research Scientist in Neurosurgery. In addition, we have an extensive collaboration with the other members of the Epilepsy Surgery Program that includes members from the Departments of Neurology, Diagnostic Radiology, Pediatrics as well as Neurosurgery.

Dr. Williamson can be reached at:
203-785-5359 or email to anne.williamson@yale.edu