Nihal deLanerolle, D.Phil.
Current Research Program
The major thrust of my current research is the analysis of human seizure foci from a multidisciplinary perspective, to elucidate the neural mechanisms underlying epileptogenesis. These studies center around three areas -- the neuroanatomical and neurochemical definition of hippocampal and neocortical seizure foci; the biochemistry and electrophysiology of neuroglia at seizure foci; and the identification of novel genes expressed at seizure foci. This work involves state-of-the-art techniques in neuroanatomy, electron microscopy, electrophysiology and molecular biology.
A second area of research where less effort is devoted, is the study of the neural mechanisms of vocalization in vertebrate animals. At present these studies explore the neural pathways in non-singing birds, in order to compare these with those in song birds which learn their vocalizations.
Relationship of Research to Neurological Disease
The studies on human seizure foci are closely linked to the human clinical epilepsy program in the department. They are undertaken in close collaboration with the clinical program. My studies have made, and should continue to have a direct impact on the redefinition of the epileptogenic substrate and the classification of seizure syndromes. In consequence these studies are important for evaluating surgical outcome, improving clinical management, and developing new pharmacotherapeutic agents.
The studies on the neural mechanisms of vertebrate vocalizations are very pertinent to understanding vocal disorders, speech mechanisms, and emotional disorders.
Dr. deLanerolle can be reached at 203-785-2597
or email to nihal.delanerolle@yale.edu
Neurosurgery Faculty/Program Menu
Department of Neurosurgery address and phone number
http://info.yale.med.edu/surgery/neurosur/neuropsycho.html
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