Publications

Selected publications. The link will open the Pubmed reference in a new window.

For the full list of publications, go to the Pubmed webpage.

  Bordey A. Enigmatic GABAergic networks in adult neurogenic regions. Brain Research Reviews (2006) In press.

  Liu X, Bolteus AJ, Balkin DM, Henschel O and Bordey A.GFAP-expressing cells in the postnatal subventricular zone display a unique glial phenotype intermediate between radial glia and astrocytes. Glia (2006) 54(5):394-410.

  Bordey A. Adult neurogenesis: basic concepts of signaling. Cell Cycle (2006) 5(7):722-8. PDF file.

  Liu X, Wang Q, Haydar TF, and Bordey A. Nonsynaptic GABAergic signaling in the postnatal subventricular zone controls GFAP-expressing cell proliferation. Nature Neuroscience (2005) 8:1179-1187. This study and the one from Dr. Bolteus (below) established the importance of intercellular signaling in controlling the behavior of stem cells and their progeny. The data contributed to the development of hypotheses regarding the role of cell:cell communication in maintaining the balance between cell proliferation and migration. This study was also the first to demonstrate the existence of a unique cell:cell signaling in a complex nonsynaptic network. A News and Views accompanied the publication of this manuscript. See Kriegstein AR. GABA puts the brake on stem cells. Nat. Neurosci. 8:1132. I designed all of the experiments and performed part of the analysis.

  Bolteus A and Bordey A. GABA release and uptake orchestrate neuronal precursor migration in the postnatal subventricular zone. Journal of Neuroscience (2004) 24: 7623-7631. This is an important paper identifying the role of cell:cell communication via GABA in controlling cell migration in the SVZ. This paper has been evaluated in Faculty of 1000: http://www.facultyof1000.com/article/15342728/evaluation.

  Huang H, and Bordey A. Glial glutamate transporters limit spillover activation of presynaptic NMDA receptors and influence synaptic inhibition of Purkinje neurons. Journal of Neuroscience (2004) 24: 5659-5669. In this manuscript, we demonstrated the existence of glutamate spillover at excitatory synapses in the cerebellum. We also showed a critical contribution of glial cells in limiting spillover resulting in an important control of synaptic strength onto neurons.

  Bordey A and Spencer DD. Distinct electrophysiological alterations in dentate gyrus versus CA1 glial cells from epileptic humans with temporal lobe sclerosis. Epilepsy Research (2004) 59:107-122.

  Wang DD, Krueger DD and Bordey A. GABA depolarizes postnatal neuronal progenitors of the subventricular zone via GABA A receptor activation. Journal of Physiology (2003) 550:785-800. This is the first paper reporting electrophysiological recordings of neuroblasts in acute slices. For the first time we also showed that GABA depolarized these neuroblasts as previously described during embryonic development. Please see the comments in Perspectives made by Gallo V and Haydar T. GABA exciting again in its own right. (2003) J. Physiol 550: 665.

  Wang DD, Krueger DD and Bordey A. Biophysical properties and ionic signature of neuronal progenitors of the postnatal subventricular zone situ. Journal of Neurophysiology (2003) 90: 2291-2302.

  Bordey A and Sontheimer H. Modulation of glutamatergic transmission by Bergmann glial cells in rat cerebellum in situ . Journal of Neurophysiology (2003) 89:979-88.

  Bordey A and Spencer DD. Chemokine modulation of large conductance Ca 2+-sensitive K + currents in microglia from human hippocampi. European Journal of Neuroscience (2003) 18: 2893-2898 .

  Barakat L. and Bordey A. Carrier-mediated uptake and release of taurine from Bergmann glia in rat cerebellar slices. Journal of Physiology (2002) 541.3:753-7 .

  Barakat L and Bordey A. GAT-1 and reversible GABA transport in Bergmann glia in situ. Journal of Neurophysiology (2002) 88:1407-19. This is the first paper characterizing GABA transporter currents in astrocytes in acute slices. This study identified the required conditions for inducing transport reversal and GABA release.

  Bordey A , Lyons S, Hablitz J and Sontheimer H. Electrophysiological characteristics of reactive astrocytes in experimental cortical dysplasia. Journal of Neurophysiology (2001) 85: 1719-31.

  Bordey A and Sontheimer H. Ion channels in astrocytes in situ: a comparison of different CNS regions. Glia (2000) 30: 27-38.

  Bordey A, Sontheimer H and Trouslard J. Muscarinic activation of BK channels induces membrane oscillations in glioma cells and leads to inhibition of cell migration. Journal of Membrane Biology (2000) 176:31-40.

  Bordey A and Sontheimer H. Electrophysiological properties of human astrocytic tumor in situ. The enigma of the spiking astrocytes. Journal of Neurophysiology (1998) 79: 2782-2793.

  Bordey A and Sontheimer H. Properties of human glial cells associated with epileptic seizure foci. Epilepsy Research (1998) 32: 285-302. This paper identified some key changes in “epileptic” astrocytes such as the loss of K + channels. These changes are now considered to be a landmark of gliotic astrocytes.

  Bordey A and Sontheimer H. Postnatal development of ionic currents in rat hippocampal astrocytes in situ. Journal of Neurophysiology (1997) 78: 461-477. This study characterized postnatal developmental changes in the biophysical properties and ion channel expression of astrocytes in acute slices. Acquisition of certain channels (inwardly rectifying K + channels) is now considered to be the hallmark of differentiating astrocytes.

  Bordey A , Feltz P, and Trouslard J. Nicotinic actions on neurones of the central autonomic area in rat spinal cord slices. Journal of Physiology (1996) 497.1: 175-188.