Yale Microarray Center
for Research on the Nervous System

Home > Center Goals

1. Provide comprehensive, state-of-the-art Affymetrix, spotted glass slide, and ABI 1700 DNA microarray analyses to as many NINDS and NIMH-supported investigators as can be supported by the requested funding and available instrumentation and as are approved by the Microarray Consortium.
2. Provide DNA microarray training and education to NINDS and NIMH-supported investigators.
3. Provide specialized services and evaluate and optimize the application of DNA microarray analysis to solve challenging research problems confronting NINDS and NIMH investigators.
   1. Select, process, and array both cDNA and oligonucleotide probes onto custom “neuroscience” glass slides for human, mouse, and rat.
   2. Evaluate different microarray platforms for relative detection sensitivity and specificity for low abundance genes expressed in neurological tissues.
   3. Bring microdissection and laser capture microscopy (LCM) within reach of NINDS and NIMH investigators.
   4. Evaluate and optimize the best small sample amplification methods.
   5. Evaluate and optimize methods for DNA microarray analysis of postmortem tissue.
4. Provide biostatistical services, develop improved analytical tools for DNA microarray analysis of neurological tissues, and move computing intensive analyses onto the new Yale Biomedical Supercomputer.
5. Develop a NINDS/NIMH Web interface for submission of DNA microarray data into the NCBI-GEO repository and Microarray Consortium relational data warehouse.