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Yale
Microarray Center
for Research on the Nervous System
Yale University
300 George Street
New Haven, CT 06511
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| Fact Sheet |
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Title of Center Grant: |
Yale/NIH Microarray Center for research on the Nervous
System |
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Grant Number: |
1 U24 NS051869-01 |
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Principal Investigator: |
Shrikant M. Mane, Ph.D |
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Awarding Agency: |
National Institute of Health Neuroscience Blueprint
Lead Institutes: National Institute of Neurological Disorders
and Stroke (NINDS) and National Institute of Mental Health (NIMH) |
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#Grants Awarded: |
4 |
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Total Funding Awarded to Yale: |
$6.5 million |
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Total Budget Period: |
7/1/2005 – 5/31/2010 |
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Center Cores: |
Affymetrix GeneChip microarray, Biostatistics, Custom
microarray, Database, Generic Microarrays, High Performance Computing |
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Center Investigators: |
14 from Yale University, the
Veterans Administration Medical Center (West Haven, CT) and Rockefeller
University |
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Specific Aims: |
- Provide comprehensive, state-of-the-art Affymetrix,
spotted glass slide, and ABI 1700 DNA microarray analyses to as many NINDS
and NIMH-supported investigators as can be supported by the requested
funding and available instrumentation and as are approved by the
Microarray Consortium
- Provide DNA microarray training and education to NINDS
and NIMH-supported investigators
- Provide specialized services and evaluate and optimize
the application of DNA microarray analysis to solve challenging research
problems confronting NINDS and NIMH investigators.
- Select, process, and array both cDNA and
oligonucleotide probes onto custom “neuroscience” glass slides for
human, mouse, and rat.
- Evaluate different microarray platforms for relative
detection sensitivity and specificity for low abundance genes expressed
in neurological tissues.
- Bring microdissection and laser capture microscopy
(LCM) within reach of NINDS and NIMH investigators.
- Evaluate and optimize the best small sample
amplification methods.
- Provide biostatistical services, develop improved
analytical tools for DNA microarray analysis of neurological tissues, and
move computing intensive analyses onto the new Yale Biomedical
Supercomputer
- Develop a NINDS/NIMH Web interface for submission of
DNA microarray data into the NCBI-GEO repository and Microarray Consortium
relational data warehouse.
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