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Week 1 (Sept. 3) Philosophy of Mind and Reductionism- M. Sloan Warren
- Into the Brain: where philosophy should go from here. Churchland (2006), Topoi 25: 29-32.
- Transcranial magnetic stimulation of the visual cortex induces somatotopically organized qualia in blind subjects. Kupers, et al. (2006). PNAS 35: 13256-13260.
Week 2 (Sept. 5 & 10) Neurogenetics- John Carlson
- A single population of olfactory sensory neurons mediates an innate avoidance behaviour in Drosophila. Suh, et al. (2004). Nature 431:854-9.
- The detection of carbonation by the Drosophila gustatory system. Fischler, et al. (2007). Nature 448: 1054-7.
Week 3 (Sept. 12 &17) Psychophysics: somatosensory- Barry Green
- Psychophysical and Physiological Evidence for Parallel Afferent Pathways Mediating the Sensation of Itch. Johanek, et al. (2007). JNeuro 27(28):7490-7497.
- Unmyelinated tactile afferents signal touch and project to insular cortex. Olausson, et al. (2002). Nature Neuroscience 5(9):900-904.
Week 4 (Sept. 19 & 24) Systems Physiology- Mark Laubach
- Modifications of Reward Expectation-Related Neuronal Activity During Learning in Primate Striatum. Tremblay, et al. (1998) JNeurophysiol 80:964-977.
- Different time courses of learning-related activity in the prefrontal cortex and striatum. Pasupathy and Miller. (2005). Nature 433:873-6.
Optional Readings:
Week 5 (Sept. 26 & Oct. 1) Neurodegeneration- Sreeganga Chandra
- Long-term effects of ABeta42 immunisation in Alzheimer’s disease: follow-up of a randomised, placebo-controlled phase I trial. Holmes, et al. (2008). Lancet 372:216-32.
- Commentary: Will anti-amyloid therapies work for Alzheimer’s disease? St George-Hyslop and Morris. (2008). Lancet 372:180-2.
- Reduced Vesicular Storage of Dopamine Causes Progressive Nigrostriatal Neurodegeneration. Caudle, et al. (2007) JNeuro 27(30):8138-8148.
Week 6 (Oct. 3 & 8) Neuronal Signaling- Michael Koelle
- C. elegans Trio's Rho-specific GEF domain is the missing G{alpha}q effector in C Elegans. Williams, et al. (2007). Genes & Dev. 21: 2731-2746.
- Structure of Gaq-p63RhoGEF-RhoAComplex Reveals a Pathway for the Activation of RhoA by GPCRs. Lutz, et al. (2007). Science 318:1923-7.
Week 7 (Oct. 10 & 15) Genetic Approaches to Neurodevelopment- Elke Stein
- The Divergent Robo Family Protein Rig-1/Robo3 Is a Negative Regulator of Slit Responsiveness Required for Midline Crossing by Commissural Axons. Sabatier, et al. (2004). Cell, Vol. 117, 157–169,
- commissureless Controls Growth Cone Guidance across the CNS Midline in Drosophila and Encodes a Novel Membrane Protein. Tear, et al. (1996). Neuron, Vol. 16, 501–514, March, 1996,
Week 8 (Oct. 17 & 22) Genetics of psychiatric disease- Arthur Simen
- Sustained hippocampal chromatin regulation in a mouse model of depression and antidepressant action. Tsankova, et al. (2006) Nature Neuroscience 9, 519-25.
- Covalent Modification of DNA Regulates Memory Formation. Sweatt, et al. (2007) Neuron 53, 857–869.
Week 9 (Oct. 24 & 29) Channels and auditory systems physiology- Joe Santos-Sacchi
Week 10 (Oct. 31 & Nov. 5) Structure of the synapse- Thomas Biederer
- Spine growth precedes synapse formation in the adult neocortex in vivo. Knott, et al. (2006) Nature Neuroscience 9(9): 1116-24.
- Crucial Role of Drosophila Neurexin in Proper Active Zone Apposition to Postsynaptic Densities, Synaptic Growth, and Synaptic Transmission. Li, et al. (2007) Neuron 55: 741-55.
Week 11 (Nov. 7 & 12) Synaptic plasticity- Chris Pittenger
- Dichotomous Dopaminergic Control of Striatal Synaptic Plasticity. Shen, et al. (2008) Science 321:848-51.
- Inducible and Selective Erasure of Memories in the Mouse Brain via Chemical-Genetic Manipulation. Cao, et al. (2008) Neuron 60:353-66.
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