Charles J. Bruce
Associate Professor
Neurobiology
Ph.D. University of North Carolina, Chapel Hill

Neurophysiology of Information Processing in Cerebral Cortex

My laboratory's research concerns cortical mechanisms of behavior and our experiments primarily involve studying the activity of single neurons in different regions of the neocortex. These neuronal recording data are complemented by several related techniques including intracortical microstimulation, physiological identification of corticocortical pathways with antidromic activation, neurochemical injection, neuroanatomical tracer injection and computer simulations of cortical networks underlying saccades.

Recent Publications

Bruce CJ, Friedman HR, Kraus MS, Stanton GB (2003) The Primate Frontal Eye Field. In: The Visual Neurosciences (Chalupa LM, Werner JS, eds.), pp 1428-1448. Cambridge, MA: MIT Press.

Bruce CJ, Friedman HR (2002) Eye Movements. In: Encyclopedia of the Human Brain (Ramachandran VS, ed.), pp 269-297. New York: Academic Press.

Shi D, Friedman HR, Bruce CJ (1998) Deficits in smooth-pursuit eye movements after muscimol inactivation within the primate's frontal eye field. J Neurophysiol 80:458-464.

Russo GS, Bruce CJ (1994) Frontal eye field activity preceding aurally guided saccades. J Neurophysiol 71:1250-1253.

Dias EC, Bruce CJ (1994) Physiological correlate of fixation disengagement in the primate's frontal eye field. J Neurophysiol 72:2532-2537.

MacAvoy MG, Gottlieb JP, Bruce CJ (1991) Smooth-pursuit eye movement representation in the primate frontal eye field. Cerebral Cortex 1:95-102.

Bruce CJ (1990) Integration of sensory and motor signals for saccadic eye movements in the primate frontal eye fields. In: Signal and Sense, Local and Global Order in Perceptual Maps (Edelman GM, Gall WE, Cowan WM, eds.), pp 261-314. New York: Wiley-Liss.

Funahashi S, Bruce CJ, Goldman-Rakic PS (1989) Mnemonic coding of visual space in the monkey's dorsolateral prefrontal cortex. J Neurophysiol 61:331-349.

Bruce CJ, Goldberg ME, Bushnell MC, Stanton GB (1985) Primate frontal eye fields. II. Physiological and anatomical correlates of electrically evoked eye movements. J Neurophysiol 54:714-734.

Bruce CJ, Goldberg ME (1985) Primate frontal eye fields. I. Single neurons discharging before saccades. J Neurophysiol 53:603-635.

Bruce CJ, Goldberg ME (1984) Physiology of the frontal eye fields. Trends Neurosci 7:436-441.

Bruce C, Desimone R, Gross CG (1981) Visual properties of neurons in a polysensory area in superior temporal sulcus of the macaque. J Neurophysiol 46:369-384.

Bruce CJ, Isley MR, Shinkman PG (1981) Visual experience and development of interocular orientation disparity in visual cortex. J Neurophysiol 46:215-228.

Shinkman PG, Bruce CJ (1977) Binocular differences in cortical receptive fields of kittens after rotationally disparate binocular experience. Science Wash DC 197:285-287.

Charles Bruce
Yale University School of Medicine
Department of Neurobiology