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  - Dr. Jorge Galán
  - Dr. Hervé Agaisse
  - Dr. Norma Andrews
  - Dr. Brett Lindenbach
- Dr. John MacMicking
  - Dr. Walther Mothes
  - Dr. Craig Roy
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Section of Microbial Pathogenesis
The Section of Microbial Pathogenesis has been established recently as a freestanding academic unit of the Yale University School of Medicine. The scientific focus of the Section is the study of microbial pathogens using multidisciplinary approaches. The
Faculty share the view that the understanding of the mechanisms by which microbial pathogens cause disease requires the understanding not only of the pathogenic microorganisms themselves but also the cellular and immune responses that they stimulate in the host. Specific areas of interest include mechanisms of pathogen internalization and survival within host cells, modulation of antigen presentation and host cell signal transduction by microbial pathogens, bacterial protein secretion, and development of antigen delivery systems for multivalent vaccines. Currently, a number of infectious diseases are under study including respiratory infections caused by Coxiella burnetii, Legionella pneumophila, and Mycobacterium tuberculosis, food poisoning and typhoid fever caused by Salmonella, Listeria, and Campylobacter spp., Chagas disease caused by Trypanosome cruzi, and chronic infections caused by blood-borne viruses like hepatitis C virus (HCV) and human immunodeficiency virus (HIV). Increasingly, microbial pathogens are becoming extremely useful biological probes to understand basic cellular functions. Several project within the Section are therefore taking advantage of these biological probes to study basic cellular processes including actin cytoskeleton dynamics, mechanisms of endo and exocytosis, intracellular traffic and G protein function. Students are therefore exposed to a multidisciplinary training environment involving a great variety of research approaches.

Faculty
Jorge E. Galán, Professor and Chairman

Hervé Agaisse, Assistant Professor

Norma Andrews, Professor

Brett Lindenbach, Assistant Professor

John MacMicking, Assistant Professor

Walther Mothes, Assistant Professor

Craig Roy, Associate Professor

 

 

Yale University
School of Medicine
Boyer Center for
Molecular Medicine
Section of Microbial
Pathogenesis
295 Congress Ave.
New Haven, CT
06536-0812 USA
 
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Yale School of Medicine, Section of Microbial Pathogenesis.
Phone (203) 737-2404, FAX (203) 737-2630.