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Section
of Microbial Pathogenesis
The Section of Microbial Pathogenesis has been established recently as a freestanding
academic unit of the Yale University School of Medicine. The scientific focus of
the Section is the study of microbial pathogens using multidisciplinary approaches.
The Faculty share the view that the understanding of the
mechanisms by which microbial pathogens cause disease requires the understanding
not only of the pathogenic microorganisms themselves but also the cellular and immune
responses that they stimulate in the host. Specific areas of interest include mechanisms
of pathogen internalization and survival within host cells, modulation of antigen
presentation and host cell signal transduction by microbial pathogens, bacterial
protein secretion, and development of antigen delivery systems for multivalent vaccines.
Currently, a number of infectious diseases are under study including respiratory infections caused by Coxiella burnetii, Legionella pneumophila, and Mycobacterium tuberculosis, food poisoning and typhoid fever
caused by Salmonella, Listeria, and Campylobacter spp., Chagas disease caused by Trypanosome cruzi, and chronic infections caused by blood-borne viruses like hepatitis C virus (HCV) and human immunodeficiency virus (HIV).
Increasingly, microbial pathogens are becoming extremely useful biological probes
to understand basic cellular functions. Several project within the Section are therefore
taking advantage of these biological probes to study basic cellular processes including
actin cytoskeleton dynamics, mechanisms of endo and exocytosis, intracellular traffic
and G protein function. Students are therefore exposed to a multidisciplinary training
environment involving a great variety of research approaches.
- Faculty
- Jorge
E. Galán,
Professor and Chairman

Hervé Agaisse,
Assistant Professor

Norma Andrews, Professor

Brett Lindenbach, Assistant Professor

John MacMicking, Assistant Professor

Walther Mothes, Assistant Professor

Craig Roy, Associate Professor
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Yale University
School of Medicine |
Boyer Center
for
Molecular Medicine |
Section of
Microbial
Pathogenesis |
295 Congress
Ave.
New Haven, CT
06536-0812 USA |
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©1999 Yale University School of Medicine. All rights reserved. Comments or suggestions
to the
site
editor. |
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Yale School
of Medicine, Section of Microbial Pathogenesis.
Phone (203) 737-2404, FAX (203) 737-2630. |
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