David Spiegel, M.D.,Ph.D.

David A. Spiegel, M.D., Ph.D.
Assistant Professor of Chemistry

A.B., 1995; Harvard College
M. Phil (Pharmacology), 2000; Yale University
M.D., 2004; Yale University
Ph.D. (Organic Chemistry), 2004; Yale University, under Prof. John L. Wood
NIH Postdoctoral Fellow, 2005-2007; Harvard University, under Prof. Stuart L. Schreiber

Research Interests

The development of chemical methods to enable the understanding and treatment of human diseases.

Representative Publications

D. A. Spiegel, F. C. Schroeder, J. R. Duvall, and S. L. Schreiber. An Oligomer-based Approach to Skeletal Diversity in Small Molecule Synthesis. Journal of the American Chemical Society, 128 (2006), 14766-14767.

D. A. Spiegel, K. B. Wiberg, L. N. Schacherer, M. R. Medeiros, and J. L. Wood. Deoxygenation of Alcohols Employing Water as the Hydrogen Atom Source. Journal of the American Chemical Society, 127 (2005), 12513-12515.

D. A. Spiegel, J. T. Njardarson, I. M. McDonald, J. L. Wood. Innovation and Art in Organic Chemistry: Synthetic Efforts Toward the Phomoidrides. Chemical Reviews, 103 (2003), 2691-2727.

D. A. Spiegel, J. T. Njardarson, J. L. Wood. CP-263,114 Synthetic studies. Construction of an isotwistane ring system via rhodium carbenoid C-H insertion. Tetrahedron, 58 (2002), 6545- 6554.

J. T. Njardarson, I. M. McDonald, D. A. Spiegel, M. Inoue, J. L. Wood. An Expeditious Approach toward the Total Synthesis of CP-263,114. Organic Letters. 3 (2001), 2435-2438.

D. A. Spiegel, D. S. Warner, M. M. Todd, F. Dexter, M. Baker. Central Nervous System Toxicities of Local Anesthetic Mixtures in the Rat. Anesthesia and Analgesia, 75 (1992), 922-928.

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