Raymond Russell, M.D.,Ph.D.

Raymond Russell, M.D.,Ph.D.
Assistant Professor of Medicine
Co-Director of Cardiovascular Training and Education
Cardiovascular Medicine

B.A. Rice University, 1984
MD, PhD, University of Texas - Houston, 1991

Research Interests

Regulation of cardiac metabolism in the setting of myocardial ischemia, heart failure and diabetes. This research focuses on the regulation of carbohydrate and fatty acid metabolism in the heart by AMP-activated protein kinase as well as the role of uncoupling proteins (UCP2 and UCP3) in metabolic regulation and cardioprotection.

Representative Publications

Russell RR, III, Li J, Coven DL, Pypaert M, Zechner C, Palmeri M, Giordano FJ, Mu J, Birnbaum MJ, and Young LH. AMP-activated protein kinase mediates ischemic glucose uptake and prevents postischemic cardiac dysfunction, apoptosis, and injury. J Clin Invest 114: 495-503, 2004.

Li J, Hu X, Selvakumar P, Russell RR, III, Cushman SW, Holman GD, and Young LH. Role of the nitric oxide pathway in AMPK-mediated glucose uptake and GLUT4 translocation in heart muscle. Am J Physiol 287: E834-841, 2004.

Russell R, Cline G, Guthrie P, Goodwin G, Shulman G, and Taegtmeyer H. Regulation of exogenous and endogenous glucose metabolism by insulin and acetoacetate in the isolated working rat heart: A three tracer study of glycolysis, glycogen metabolism and glucose oxidation. J Clin Invest 100: 2892-2899, 1997.

Russell RR, Bergeron R, Shulman GI, and Young LH. Translocation of myocardial GLUT4 and increased glucose uptake through activation of AMP-activated protein kinase by AICAR. Am J Physiol 277: H643-H649, 1999.

Russell R, Renfu Y, Caplan M, Hu X, Ren J, Shulman G, Sinusas A, and Young L. Additive effects of hyperinsulinemia and ischemia on myocardial GLUT1 and GLUT4 translocation in vivo. Circulation 98: 2180-2186, 1998.


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