David Rimm, M.D.,Ph.D.

David Rimm, M.D.,Ph.D.
Associate Professor of Pathology
Director of the Yale Cancer Center Tissue Microarray Facility

University of Wisconsin Madison 1977-81 B.S. (Honors)
Johns Hopkins School of Medicine 1981-89 M.D.-Ph.D.
Yale-New Haven Hospital 1989-93 Pathology Residency
Medical College of Virginia 1993-94
Cytopathology Fellowship

Research Interests

My lab group focuses on in situ quantitative assessment of tissue biomarkers, including predicting outcomes and response to therapies in breast and colon cancer and melanoma. A subset of his group studies the cell and molecular biology of cell adhesion and growth factor receptors. A third subset works on spectral-spatial analysis of cytologic specimens.

Representative Publications

Camp, R.L. Chung, G.G., and Rimm, D.L. (2002) Automated subcellular localization and quantification of protein expression in tissue microarrays. Nature Medicine 8(11):1323-7

Camp R.L., Dolled-Filhart, M., and Rimm D.L. (2004) X-tile: A new bio-informatics tool for biomarker assessment and outcome-based cut-point optimization. Clin Cancer Res. 10(21):7252-9.

Provost, E., McCabe, A., Stern, J., Lizardi, I., D'Aquila, T. G., and Rimm, D. L. (2005). Functional correlates of mutation of the Asp32 and Gly34 residues of beta-catenin. Oncogene 24, 2667-2676.

Kluger, H.M., Chelouche Lev, D., Kluger, Y., McCarthy, M.M., Kiriakova, G., Camp, R.L., Rimm, D.L., and Price, J.E. (2005). Using a xenograft model of human breast cancer metastasis to find genes associated with clinically aggressive disease. Cancer Res65: 5578-5587.