The M.D.-Ph.D. Program at Yale University

Fred Gorelick
Professor of Medicine and Cell Biology

University of Missouri School of Medicine, M.D. (5/1/73)
Post-doctoral Fellowship: Yale University, 1976-1979
Research training: 1977-1980: James D. Jamieson, Yale University (pancreatic acinar cell function); 1986-1987: Paul Greengard, Rockefeller University (protein kinases)

Research Interests

Pathologic proteolytic activation of zymogens and pancreatitis
Vesicular trafficking in reference to the budding of lipid vesicles from the endoplasmic reticulum

Representative Publications

Lu, Z., Karne, S., Kolodecik, T., and Gorelick, F. (2002). Sensitization of pancreatic acinar cells to cholecystokinin-induced zymogen activation is related to the structure of alcohols. Am. J. Physiol. 282:G501-G507.

Z. Lu, T. Kolodecik, F. S. Karne, M. Nyce, Gorelick. Agonists of cAMP sensitize the acinar cell to cerulein-induced zymogen activation Amer J. Physiol. 2003 285:G822-8

Shadiqui, S., Gorelick, F., and Mansbach, C.(2003). Budding of prechylomicron vesicles from the endoplasmic reticulum is COPII independent. J. Cell Sci. 116:415-427.