Recent Publications
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2011
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| R.J. Tomko Jr and M. Hochstrasser (2011) Incorporation of the Rpn12 subunit couples completion of proteasome regulatory particle lid assembly to lid-base joining. Mol. Cell. 44, 907-917. | |
| J.D. Laney and M. Hochstrasser (2011) Analysis of protein ubiquitination. In: Curr. Protoc. Protein Sci. John Wiley and Sons: Hoboken, NJ. Unit 14.5:pp 14.5.1-13. | |
| R. Felberbaum, N.R. Wilson, D. Cheng, J. Peng and M. Hochstrasser (2011) Desumoylation of the endoplasmic reticulum membrane VAP family protein Scs2 by Ulp1 and SUMO regulation of the inositol synthesis pathway. Mol. Cell. Biol. 32, 64-75. | |
| A.R. Kusmierczyk, M.J. Kunjappu, R.Y. Kim and M. Hochstrasser (2011) A conserved 20S proteasome assembly factor requires a C-terminal HbYX motif for proteasomal precursor binding. Nat. Struct. Mol. Biol. 18, 622-629. | |
| S.G. Kreft and M. Hochstrasser (2011) An unusual transmembrane helix in the endoplasmic reticulum ubiquitin ligase Doa10 modulates degradation of its cognate E2 enzyme. J. Biol. Chem. 286, 20163-20174. | |
| R.J. Tomko Jr and M. Hochstrasser (2011) Order of the proteasomal ATPases and eukaryotic proteasome assembly. Cell. Biochem. Biophys., 60, 13-20. | |
| 2010 | |
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E.M. Rubenstein and M.
Hochstrasser (2010) Redundancy and variation in the ubiquitin-mediated proteolytic
targeting of a transcription factor. Cell Cycle, 9, 4282-4285.
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D. Su and M. Hochstrasser (2010)
A WLM Protein with SUMO-Directed Protease Activity. Mol Cell Biol., 30, 3734-3736.
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R.J. Tomko Jr, M. Funakoshi, K.
Schneider, J. Wang M. Hochstrasser (2010) Heterohexameric Ring Arrangement of
the Eukaryotic Proteasomal ATPases: Implications for Proteasome Structure and
Assembly. Mol. Cell, 38, 393-403.
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Y. Xie, E.M. Rubenstein, T. Matt
and M. Hochstrasser (2010) SUMO-independent in vivo activity of a
SUMO-targeted ubiquitin ligase toward a short-lived transcription factor.
Genes and Development, 24:893-903.
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A.L. Cortajarena, T.Y. Liu, M.
Hochstrasser and L. Regan (2010) Designed proteins to modulate cellular
networks. ACS Chem. Biol., 5(6):545-552.
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2009 |
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P. Xu, D.M. Duong, N.T.
Seyfried, D. Cheng, Y. Xie, J. Robert, J. Rush, M. Hochstrasser, D. Finley,
and J Peng. (2009) Quantitative proteomics reveals the function of
unconventional ubiquitin chains in proteasomal degradation. Cell,
137(1):133-145.
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M. Hochstrasser (2009) The
ubiquitin-proteasome system. In: Handbook of Cell Signaling, 2nd edition.
R.A. Bradshaw and E.A. Dennis (Eds.) Elsevier Press: San Diego. Chapter 162:
pp. 1291-1294. |
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M. Hochstrasser (2009)
Introduction to Intracellular Protein Degradation. Chem. Rev.,
109(4):1479-1480.
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C.E. Cook, M. Hochstrasser and
O. Kerscher (2009) The SUMO-targeted ubiquitin ligase subunit Slx5 resides in
nuclear foci and at sites of DNA breaks. Cell Cycle, 8(7):1080-1089.
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P.A. Osmulski, M. Hochstrasser,
and M. Gaczynska (2009) A Tetrahedral Transition State at the Active Sites of
the 20S Proteasome Is Coupled to Opening of the alpha-Ring Channel.
Structure, 17(8):1137-1147.
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M. Funakoshi, R.J. Tomko Jr. H.
Kobayashi, and M. Hochstrasser (2009) Multiple Assembly Chaperones Govern
Biogenesis of the Proteasome Regulatory Particle Base. Cell, 137(5):887-899.
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Hochstrasser (2009) Origin and
function of ubiquitin-like proteins. Nature, 458(7237):422-9. |
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M. Funakoshi and M. Hochstrasser
(2009) Small epitope-linker modules for PCR-based C-terminal tagging in
Saccharomyces cerevisiae. Yeast, 26(3):185-192.
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M.B. Kroetz, D. Su, and M.
Hochstrasser (2009) Essential Role of Nuclear Localization for Yeast Ulp2
SUMO Protease Function. Mol. Biol. Cell., 20(8):2196-2206.
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M.B. Kroetz and M. Hochstrasser
(2009) Identification of SUMO-Interacting Proteins by Yeast Two-Hybrid
Analysis. Methods Mol. Biol., 497:107-120.
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2008 |
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L. Wang, H. Dong, C.J. Soroka,
N. Wei, J.L. Boyer, and M. Hochstrasser (2008) Degradation of the Bile Salt
Export Pump at Endoplasmic Reticulum in Progressive Familial Intrahepatic
Cholestasis Type II. Hepatology, 48(5):1558-1569.
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A.R. Kusmierczyk and M.
Hochstrasser (2008) Some assembly required: dedicated chaperones in
eukaryotic proteasome biogenesis. Biol. Chem. 389(9), 1143-1151.
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R. Felberbaum and M.
Hochstrasser (2008). Ulp2 and the DNA damage response: Desumoylation enables
safe passage through mitosis. Cell Cycle 7, 52-56. |
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A.R. Kusmierczyk, M.J. Kunjappu,
M. Funakoshi, and M. Hochstrasser (2008). A multimeric assembly factor
controls formation of alternative 20S proteasomes. Nat. Struct. Mol. Biol.
15, 237-244. |
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T. Ravid and M. Hochstrasser
(2008). Diversity of degradation signals in the ubiquitin–proteasome system.
Nat. Rev. Mol. Cell Biol. 9(9), 679-690. |
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M. Hochstrasser, M. Deng, A.R.
Kusmierczyk, X. Li, S. Kreft, T. Ravid, M. Funakoshi, M. Kunjappu and Y. Xie
(2008). Molecular genetics of the ubiquitin-proteasome system: Lessons from
yeast. In: Ernst Schering Foundation Symposia Proceedings (Springer Verlag),
pp. 41-66. |
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2007 |
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T. Ravid and M. Hochstrasser
(2007). Autoregulation of an E2 enzyme by ubiquitin-chain assembly on its
catalytic residue. Nature Cell Biol., 9(4), 422-427. |
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X. Li, A.R. Kusmierczyk, P.
Wong, A. Emili, and M. Hochstrasser (2007). beta-Subunit appendages promote
20S proteasome assembly by overcoming an Ump1-dependent checkpoint. EMBO J.
26, 2339-2349. |
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D.C. Schwartz, R. Felberbaum,
and M. Hochstrasser (2007). The Ulp2 SUMO protease is required for cell
division following termination of the DNA damage checkpoint. Mol. Cell. Biol.
27, 6948-6961. |
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A. Lewis*, R. Felberbaum*, and
M. Hochstrasser (2007). A nuclear envelope protein linking nuclear pore
basket assembly, SUMO protease regulation, and mRNA surveillance. J. Cell
Biol. 178, 813-827. [*equal contribution] |
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Y. Xie*, O. Kerscher*, M.
Kroetz, H. McConchie, P. Sung, and M. Hochstrasser (2007). The yeast
Hex3-Slx8 heterodimer is a ubiquitin ligase stimulated by substrate
sumoylation. J. Biol. Chem. 282, 34176-34184. [*equal contribution] |
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M. Hochstrasser (2007).
Ubiquitin ligation without a ligase. Dev. Cell 13, 4-6. |
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2006 |
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A.Y. Amerik, N. Sindhi, and M.
Hochstrasser (2006). A conserved late endosome-targeting signal required
for Doa4 deubiquitylating enzyme function. J. Cell Biol. 175, 825-835. |
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M. Deng and M. Hochstrasser
(2006). Spatially regulated ubiquitin ligation by an ER/nuclear membrane
ligase. Nature 443, 827- 831. |
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M.F. Arteaga, L. Wang, T. Ravid,
M. Hochstrasser, and C.M. Canessa (2006). A short amphipathic helix targets
Sgk1 to the ER- associated ubiquitin-conjugation machinery. Proc. Natl. Acad.
Sci. U.S.A. 103, 11178-11183. |
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O. Kerscher*, R. Felberbaum*,
and M. Hochstrasser (2006). Modification of proteins by ubiquitin and
ubiquitin-like proteins. Annu. Rev. Cell Dev. Biol. 22, 159-180. [*equal
contribution] |
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M. Hochstrasser (2006). The
ubiquitin system: Key insights from Saccharomyces cerevisiae.
In: Landmark Papers in Yeast Biology. P. Linder, D. Shore, and M.N.
Hall (eds.) Cold Spring Harbor Laboratory Press: Cold
Spring Harbor, pp. 267-284. |
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T. Ravid, S.G. Kreft, and M.
Hochstrasser (2006). Membrane and soluble substrates of the Doa10 ubiquitin
ligase are degraded by distinct pathways. EMBO J. 25,
533-543. |
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M. Hochstrasser (2006).
Biochemical functions of ubiquitin and ubiquitin-like protein
conjugation. In: Protein Degradation, vol.
2: The Ubiquitin-Proteasome System. R.J. Mayer, A. Ciechanover,
and M. Rechsteiner (Eds.) Wiley-VCH Verlag: Weinheim, pp. 249-278. |
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M. Hochstrasser (2006). Lingering
mysteries of ubiquitin-chain assembly. Cell 124, 27-34. |
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S.G. Kreft, L. Wang, and M.
Hochstrasser (2006). Membrane topology of the yeast endoplasmic
reticulum-localized ubiquitin ligase Doa10 and comparison to its human
ortholog TEB4 (MARCH VI). J. Biol. Chem. 281, 4646-4653. |
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J.D. Laney E.F. Mobley, and M.
Hochstrasser (2006). The short-lived Matalpha2 transcriptional repressor is
protected from degradation in vivo by interactions with the Tup1 and Ssn6
co-repressors. Mol. Cell. Biol. 26, 371-380. |
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2005 |
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S.-J. Li, W. Hankey, and M.
Hochstrasser (2005). Preparation and characterization of yeast and human
desumoylating enzymes. Meth. Enzymol. 398, 457-467. |
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S. Huang, H. Zhou, D. Katzmann,
M. Hochstrasser, E. Atanasova, and Z. Zhang (2005). Rtt106p is a histone
chaperone involved in heterochromatin-mediated silencing. Proc. Natl. Acad.
Sci. U.S.A. 102, 13410-13415. |
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J.T. Hannich, A. Lewis, M.
Kroetz, S.-J. Li, A. Emili and M. Hochstrasser (2005). Defining the
SUMO-modified proteome by multiple approaches in Saccharomyces cerevisiae. J.
Biol. Chem. 280, 4102-4110. |
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2004 |
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M. Funakoshi*, X. Li*, I.
Velichutina*, M. Hochstrasser and H. Kobayashi (2004). Sem1, the yeast
ortholog of a human BRCA2- binding protein, is a component
of the proteasome regulatory particle and is required for its stability. J.
Cell Science 117, 6447- 6457. [*equal contribution] |
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A.Y. Amerik and M. Hochstrasser
(2004). Mechanism and function of deubiquitinating enzymes. Biochim. Biophys.
Acta. [Special edition on ubiquitin]. 1695, 189-207. |
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J.D. Laney and M. Hochstrasser
(2004). Ubiquitin-dependent control of development in Saccharomyces
cerevisiae. Curr. Opin. Microbiol. 7, 647-654. |
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T. Ravid and M. Hochstrasser
(2004). NFkappaB signaling: Flipping the switch with polyubiquitin
chains. Curr. Biol. 14, R898- 900. |
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G. Huyer, W. F. Piluek, Z.
Fansler, S.G. Kreft, M. Hochstrasser, J.L. Brodsky, and S. Michaelis (2004)
Distinct machinery is required in Saccharomyces cerevisiae for the
endoplasmic reticulum-associated degradation of a multispanning membrane
protein and a soluble lumenal protein. J. Biol. Chem. 279, 38369-38378. |
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A.Y. Amerik and M. Hochstrasser
(2004). The Saccharomyces cerevisiae deubiquitinating enzyme
Doa4. In: Handbook of Proteolytic Enzymes. A.J.
Barrett, N.D. Rawlings and J.F. Woessner (eds.) Academic Press: New
York. Vol. 2, pp. 1229-1232. |
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M. Hochstrasser (2004).
Ubiquitin signaling: What's in a chain? Nature Cell Biol. 6, 571-572. |
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I. Velichutina*, P.L. Connerly*,
C.S. Arendt, X. Li, and M. Hochstrasser (2004) Plasticity in eukaryotic 20S
proteasome ring assembly revealed by a subunit deletion in yeast. EMBO J. 23,
500-510. [*equal contribution] |
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2003 |
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M. Hochstrasser (2003). The
ubiquitin-proteasome system. In: Handbook of Cell
Signaling. R.A. Bradshaw and E.A. Dennis
(Eds.) Elsevier Press: San Diego. Vol. 2, pp. 347-350. |
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J.D. Laney and M. Hochstrasser
(2003). Ubiquitin-dependent degradation of the yeast Matalpha2
transcriptional repressor enables a switch in developmental state. Genes
& Devel. 17, 2259-2270. |
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D. Schwartz and M. Hochstrasser
(2003). A superfamily of protein tags: Ubiquitin, SUMO, and related
modifiers. Trends Biochem. Sciences 28, 321-328. |
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S.-J. Li and M. Hochstrasser
(2003). The Ulp1 SUMO isopeptidase: Distinct domains required for viability,
nuclear envelope localization, and substrate specificity. J. Cell
Biology 160, 1069-1081. |
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2002 |
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J.D. Laney and M. Hochstrasser
(2002). Assaying protein ubiquitination. In: Current
Protocols in Protein Science, John Wiley & Sons: Rockville, MD, pp.
14.5.1-14.5.11. |
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M. Hochstrasser (2002) New
proteases in a ubiquitin stew. Science 298, 549-552. |
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J.D. Laney, and M. Hochstrasser
(2002) Assaying protein ubiquitination in S. cerevisiae. Meth. Enzymol.
351, 248-257. |
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M. Hochstrasser (2002). New
structural clues to substrate specificity in the ubiquitin system. Molecular
Cell 9, 453-454. |
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2001 |
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R. Swanson, M. Locher and M.
Hochstrasser (2001) A conserved ubiquitin ligase of the nuclear
envelope/endoplasmic reticulum that functions in both
ER-associated and Matalpha2 repressor degradation. Genes & Devel.
15, 2660-2674. |
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M. Hochstrasser (2001) SP-RING
for SUMO: New functions bloom for a ubiquitin-like protein. Cell 107, 5-8. |
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M. Hochstrasser and J. Wang
(2001). Unraveling the means to the end in ATP-dependent proteases. Nature
Struct. Biol. 8, 294- 296. |
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2000 |
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A.Y. Amerik, S.-J. Li, and M.
Hochstrasser (2000). Analysis of the deubiquitinating enzymes of the yeast
Saccharomyces cerevisiae. Biol. Chem. 381, 981-992. |
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A.Y. Amerik, J. Nowak, S.
Swaminathan, and M. Hochstrasser (2000). The Doa4 deubiquitinating
enzyme is functionally linked to the vacuolar-protein-sorting and endocytic
pathways. Mol. Biol. Cell 11, 3365-3380. |
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M. Hochstrasser (2000). All in
the ubiquitin family. Science 289, 563-564. |
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M. Hochstrasser (2000).
Evolution and function of ubiquitin-like protein conjugation systems. Nature
Cell Biol. 2, E153-E157. |
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R. Swanson and M. Hochstrasser
(2000). A viable ubiquitin-activating enzyme mutant for evaluating
ubiquitin system function in Saccharomyces cerevisiae. FEBS Lett. 477,
193-198.
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S.-J. Li and M. Hochstrasser (2000).
The yeast ULP2 (SMT4) gene encodes a novel protease specific for the
ubiquitin-like Smt3 protein. Mol. Cell. Biol. 20, 2367-2377. |