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Immunology
and Flow Cytometry: CD5/C8 Mountains
Flow
cytometry immunophenotyping analysis of peripheral blood lymphocytes
following bone marrow transplantation. "Unusual" immunophenotype cells
may be found in patients following hematopoietic transplantation;
these cells generally represent immunocytes that are present in normal
physiology but in relatively low numbers. Here a population of CD5
low or negative expressing CD8+ CD3+ cells are identified. For more
information see:
- Bierer
BE, Nishimura Y, Burakoff SJ, Smith BR. 1988. Phenotypic and Functional
Characterization of Human Cytolytic T Cells Lacking Expression
of CD5. J Clin Invest 81:1390-1397.
- Smith
BR. 1988. Flow Cytometric Analysis of Circulating Lymphocytes
Following Human Marrow Transplantation. Cytometry 9:48-52.
- Bierer
BE, Burakoff SJ, Smith BR. 1989. A Large Proportion of T Lymphocytes
Lack CD5 Expression Following Bone Marrow Transplantation. Blood
73:1359-1366.
- Leitenberg
D, Rappeport JM, Smith BR. 1994. Precursor B Cell Bone Marrow
Reconstitution Following Marrow Transplant. Am J Clin Pathol 102:231-236.
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