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Edward Snyder , MD

Professor of Laboratory Medicine/Associate Chair for Clinical Affairs
Director, Apheresis/Transfusion Service
Director, Blood Bank
Director, Transfusion Medicine Fellowship
Editor, Lab News

Office: CB-459
Phone: 203-688-2441
Fax: 203-688-2748
Email: edward.snyder@yale.edu

B.A., 1967, Harpur College State University of New York at Binghamton
M.A., 1969, Harpur College State University of New York at Binghamton
M.D., 1973, New York Medical College
Fellowship: Hematology/Transfusion Medicine, Montefiore Hospital

Community of Science Biosketch

Research Interests
Dr. Snyder's research relates to the broad field of Transfusion Medicine and, more specifically, Transfusion Oncology and Transfusion Immunobiology. His current research includes an on-going evaluation of the platelet storage lesion. This includes evaluation of alterations that occur in platelet metabolism during various storage conditions, in the platelet's cystoskeleton and in the mitochondria within platelets. Studies of the in vitro and in vivo aspects of platelet storage are an on-going effort in the laboratory. Dr. Snyder also has a long-term history of investigating the role of leukodepletion in blood components. Most recently, the laboratory has turned to the evaluation of new pathogen reduction technology. This includes the addition of various compounds to blood to remove known and potentially dangerous, as well as unknown, viral, bacterial, and protozoal contaminants in donated blood. The laboratory has a special expertise in radiolabeling human blood cells. The laboratory is currently performing clinical trials related to in vivo recovery and survivals using indium-111 and chromium-51 radiolabeled platelets and red cells, as well as Phase III trials for transfusion of pathogen-reduced blood components into patients. We are also involved in ongoing evaluations of clinical responses of patients to pheresis interventions for a variety of immunologic disorders. This is often done in conjunction with the evaluation of new apheresis machine hardware developed by a variety of corporations.

Clinical and Teaching Activities
Dr. Snyder is Board Certified in Internal Medicine, Hematology, and Transfusion Medicine. His clinical work is aimed at transfusion practice and primarily encompasses classical transfusion medicine, as well as the clinical apheresis service where he is responsible for the oversight of the plasmapheresis, leukapheresis, and plateletpheresis services. We are also involved in the collection and processing of peripheral blood stem cells for the Yale Stem Cell Transplant Program and in the collection of mononuclear cells for donor lymphocyte infusion. Dr. Snyder is the medical director of the Frisbee Laboratory, a Class 10,000 facility for the preparation of cellular therapy products. Dr. Snyder participates in the Department of Laboratory Medicine's T-32 NIH grant for training in immunohematology and transfusion medicine. To E-mail Dr. Snyder, please click here.

Publications

Snyder EL, McCullough J, Slichter SJ, Strauss RG, Lopez-Plaza I, Lin J-S, Corash L and Conlan MG for the SPRINT Study Group. Clinical Safety of Platelets Photochemically Treated with Amotosalen HCl and Ultraviolet A Light for Pathogen Inactivation: The SPRINT Trial. Transfusion 2005;45:1864-75.

AuBuchon JP, Snyder EL.The rationale for a standardized approach to assessment of platelet kinetics. Transfusion 2006;46:(in press).

Slichter SJ, Baril L, Corda T, Dincecco D, Bolgiano D, MK Jones, Christoffel T, Corson J, Snyder EL. Viability and function of 8-day stored Haemonetics& apheresis platelets. Transfusion 2006;46:(in press).

Snyder EL, O'Donnell L, Dengler TJ, Pomper GJ, Velleca MA, Dincecco DM, Baril LL, Min K, Gudino MD, Bender JR. Ex vivo evaluation of PBMNCs collected with a new cell separator. Transfusion 41:940-949, 2001.

Debalak J, Shlomchik MJ, Snyder EL,Krause DS. Isolation of T cell depleted CD34+ peripheral blood stem cells using the Isolex 300I magnetic cell separator. Bone Marrow Transplantation, in press, 2001.

Snyder EL, et al. In vitro collection and post-transfusion engraftment of MNCs obtained by using a new separator for autologous PBPC transplantation. Transfusion 40:961-967, 2000.

McQuiston JH,Snyder EL, Chamberland ME. Transmission of tickborne agents by blood transfusion. Transfusion 40:274-284, 2000.

Burtness BA, Psyrri A, Rose M, Snyder EL,Cooper D. A phase I study of pacitaxel for mobiliation of peripheral blood progenitor cells. Bone marrow Transplantation 23:311-315, 1999.

Snyder EL, Perrotta P, Rinder H, Baril L, Nichol J. Effects of PEG-rHu megakaryocyte growth and development factor on the platelet storage lesion. Transfusion 39:258-264, 1999.

Perrotta PL, Baril, L, Tead C, Chapman J, Buchholz D, Snyder EL. Effects of methylene blue-treated plasma on red cells and stored platelet concentrates. Transfusion 39:63-69, 1999.

Klein HG, Dodd RY, Dzik WH, Luban NL, Ness P, Pisciotto P. Schiff P, Snyder E. Status of solvent/detergent-treated frozen plasma. Transfusion 38:102-107, 1998.

Geiger TL, Perrotta P, Davenport R, Baril L, Snyder EL. Removal of C3a and C5a and chemokines IL-8, RANTES by leukoreduction and plasma filters. Transfusion 37:1156-1162, 1997.

Snyder EL, Mechanic S, Baril L, Davenport R. Removal of soluble BRMs (complement and chemokines) by a bedside leukoreduction filter. Transfusion 36:707-713, 1996.

Blundell EL, Pamphilon D, Fraser I, Kagen L, Menitove J, Aster R, Greenwalt T, Snyder EL, et al. A prospective randomized study of platelet concentrates irradiated with UV-B light in patients with haematological malignancy. Transfusion 36:296-302, 1996.

Stack G, Baril L, Napychank P, Snyder EL. Cytokine generation in stored white cell reduced and bacterially contaminated units of red cells. Transfusion 35:199-203, 1995.

Geiger T, Pisciotto P, Baril L, Snyder EL. The effect of solvent detergent treated plasma on stored red cells in vitro. Transfusion 35:487-492, 1995.

Stack G, Snyder EL. Cytokine generates in stored platelet concentrates. Transfusion 34:20-25, 1994.

Buchholz DH, AuBuchon JP, Snyder EL, et al. Effects of white cell reduction on the resistance of blood components to bacterial multiplication. Transfusion 34:20-25, 1994.