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Henry M. Rinder, MD

Associate Professor of Laboratory Medicine and Internal Medicine
Director, Clinical Hematology Laboratory
Associate Director, Immunology and Flow Cytometry Laboratories
Co-director, Yale Pathology Residency Program
Director, Clinical Pathology Residency Training
Director, Laboratory Medicine Cases On-Line

Fitkin 617;
203-688-8176; fax 203-688-4111
henry.rinder@yale.edu

1979 B.S., Yale College
1984 M.D., University of Vermont College of Medicine
Residencies and Fellowships: Maine Medical Center, Portland, ME; Yale University and Yale-New Haven Hospital, New Haven, CT

Community of Science Biosketch

Research Interests

Dr. Rinder's research interests primarily revolve around cellular coagulation and platelet physiology in two related areas. First, the laboratory investigates the biology of platelet activation and subsequent leukocyte-platelet adhesive interactions. Our laboratory has investigated the responsible receptor-ligand pairs, the adhesive alterations as a result of signal transduction, and differences in functional cell adhesion based on cell lineage and phenotype. This bench investigation has led the laboratory into studying the mechanisms of platelet and leukocyte activation during platelet storage and in the settings of extracorporeal circulation and drug abuse.

References

• Rinder CS, Rinder HM, Smith MJ, Fitch JCK, Tracey JB, Chandler WL, Rollins SA, Smith BR. Antithrombin reduces monocyte and neutrophil CD11b upregulation in addition to blocking platelet activation during extracorporeal circulation. Transfusion 46:1130-1137, 2006.
• Mathew JP, Rinder HM, Smith BR, Newman MF, Rinder CS. Transcerebral Platelet Activation after Aortic Cross-Clamp Release is Linked to Neurocognitive Decline. Ann Thorac Surg 81:1644-1649, 2006.
• Fontes ML, Mathew JP, Rinder HM, Zelterman DZ, Smith BR, Rinder CS. Atrial fibrillation after CPB is associated with monocyte activation. Anesth & Analg. 101:17-23, 2005.
• Rinder CS, Fontes M, Mathew JP, Rinder HM, Smith BR. Neutrophil CD11b upregulation during cardiopulmonary bypass is associated with postoperative renal injury. Ann Thorac Surg 75:899-905; 2003.
• Smith BR, Rinder CS, Rinder HM. Interaction of Blood and Artificial Surfaces. In: Loscalzo J, Schafer AI (eds) "Thrombosis and Hemorrhage, 3rd Edition" (Williams and Wilkins, Baltimore, MD) pp865-885, 2002.
• Smith BR, Rinder HM, Rinder CS. Cardiopulmonary bypass. In: Michelson, AD (ed) "Platelets" (Academic Press, New York) pp727-744, 2002.
• Rinder CS, Mathew JP, Rinder HM, Howe JG, Fontes M, Crouch J, Pfau S, Patel P, Smith BR. Platelet PlA2 polymorphism and platelet activation are associated with increased troponin I release after cardiopulmonary bypass. Anesthesiology 97:1118-1122, 2002.
• Griffin MJ, Rinder HM, Smith BR, Tracey JB, Kriz NS, Li CK, Rinder CS.The Effects of Heparin, Protamine, and Heparin/Protamine Reversal on Platelet Function Under Conditions of Arterial Shear Stress. Anesth Analg 93:20 -7, 2001.
• Rinder HM, Rinder CS. Preservation of platelet function after cardiac surgery and apheresis. In Platelet therapy: current status and future challenges. Seghatchian J, Snyder EL, and Krailadsiri P, eds. Elsevier Science, Amsterdam pp.169-198, 2000.
• Margolin A, Avants SK, Setaro J, Rinder HM, Grupp, L. Cocaine, HIV, and their cardiovascular effects: Is there a role for ACE-inhibitor therapy? Drug and Alcohol Dependence 61:35-45, 2000.
• Rinder HM, Rinder CS. Preservation of platelet function after cardiac surgery and apheresis. In Platelet therapy: current status and future challenges. Seghatchian J, Snyder EL, and Krailadsiri P, eds. Elsevier Science, Amsterdam pp.169-198, 2000.

Our second area of interest has been the detection of that subset of platelets which is most recently released from the circulation ("reticulated platelets"), analogous to red cell reticulocytes. Enumeration of reticulated platelets has allowed our laboratory to explore platelet kinetic diagnostics in patients with different etiologies of thrombocytopenia, in patients with thrombotic disorders, and in those recovering from marrow injury. These studies have also led to bench studies of reticulated platelet function and general platelet function disorders in order to discern the differential hemostatic potential of the youngest circulating platelets.

References

• Greilich PE, Brouse CF, Rinder CS, Smith BR, Sandoval BA, Rinder HM, Eberhart RC, Jessen ME. Effects of e-Aminocaproic Acid and Aprotinin on Leukocyte-Platelet Adhesion in Patients Undergoing Cardiac Surgery. Anesthesiology 100:225-33, 2004.
• Kosten TR, Tucker K, Gottschalk PC, Rinder CS, Rinder HM. Platelet Abnormalities Associated with Cerebral Perfusion Defects in Cocaine Dependence. Biological Psychiatry 55:91-97, 2004.
• Rinder HM, Snyder EL, Tracey JB, Dincecco D, Wang C, Baril L, Rinder CS, Smith BR. Reversibility of severe metabolic stress in stored platelets following in vitro plasma rescue or in vivo transfusion: restoration of secretory function and maintenance of platelet survival. Transfusion 43:1230-1237, 2003.
• Kosten TR, Gottschalk PC, Tucker K, Rinder CS, Dey H, Rinder HM. Aspirin or amiloride for cerebral perfusion defects in cocaine dependence. Drug and Alcohol Dependence 71:187-194, 2003.
• Angelopoulou M, Novelli E, Grove JE, Rinder HM, Civin C, Cheng L, Krause DS. Cotransplantation of human mesenchymal stem cells enhances human hematopoiesis in NOD/SCID mice. Exp Hematol 31:413-20, 2003.
• Snyder EL, Rinder HM. Clinical implications of basic research: Platelet storage - time to come in from the cold? N Engl J Med 348:2032-2033, 2003.
• Rinder HM, Smith BR. In vitro evaluation of stored platelets: is there hope for predicting post-transfusion platelet survival and function? Transfusion 43:2-6, 2003.
• Rinder HM. Platelet kinetics and hemostasis. In: Simon TL, Dzik WH, Snyder EL, Stowell CP, and Strauss RG (eds) "Rossi's Principles of Transfusion Medicine", 3rd Edition. (Lippincott, Williams, & Wilkins, Philadelphia, PA) pp192-202, 2002.
• Perez LE, Rinder HM, Wang C, Tracey JB, Maun N, Krause D. Xenotransplantation of immunodeficient mice with human blood CD34+ cells provides an in-vivo model for human megakaryocytopoiesis and platelet production. Blood 97:1635-43, 2001.
• Rinder HM. Disorders of hemostasis: thrombosis. In Cecil Essentials of Medicine, Fifth Ed. Andreoli TF, Carpenter CCJ, Griggs RC, and Losacalzo J, eds. pp. 473-482, WB Saunders, Philadelphia 2000.
• Rinder HM. Disorders of hemostasis: bleeding. In Cecil Essentials of Medicine, Fifth Ed. Andreoli TF, Carpenter CCJ, Griggs RC, and Losacalzo J, eds. pp. 457-472, WB Saunders, Philadelphia 2000.
• Rinder HM. Normal hemostasis. In Cecil Essentials of Medicine, Fifth Ed. Andreoli TF, Carpenter CCJ, Griggs RC, and Losacalzo J, eds. pp. 449-456, WB Saunders, Philadelphia 2000.
  
• Rinder HM, Optimal dosing and triggers for prophylactic use of platelet transfusions. In Thrombocytopenia in Oncology, Jain V, ed. 1:5-8, 2000.

The laboratory accepts graduate students directly through the Yale Program in Biomedical Engineering or as an adjunct laboratory through the Graduate School Combined Programs in Biological and Biomedical Sciences. Post-doctoral fellows (MD, PhD or MD/PhD) are also accepted, most commonly through the Departments of Laboratory Medicine, Pathology, Internal Medicine/Hematology, Internal Medicine/Oncology, Anesthesiology, Pediatrics/Hematology-Oncology, or Pediatrics/Infectious Diseases. Yale medical students may elect to work in the laboratory through the standard thesis mechanism and Yale undergraduate students may apply through the Molecular Biochemistry and Biophysics course. To e-mail Dr. Rinder, please click here.

Clinical and Teaching Activities
Dr. Rinder sees adult hematology/oncology patients and carries out pathology interpretative clinical work through the Yale Faculty Practice. Dr. Rinder is actively involved in teaching at the graduate level through the Laboratory Medicine and Hematology teaching programs at the Yale School of Medicine. Dr. Rinder also teaches residents, fellows, postdoctoral and graduate students and at continuing education courses organized through the Yale Cancer Center, and the Departments of Internal Medicine and Laboratory Medicine.