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Herbert
Malkus
Assistant
Clinical Professor of Laboratory Medicine
Associate Director of Clinical
Chemistry
CB 538
(203) 688-2444
herbert.malkus@yale.edu
BS
1964 Brooklyn College
PhD 1968 Iowa State University
Fellowship 1971 Yale University School of Medicine
Research
Interests
Markers of cardiac injury: Rapid identification of cardiac injury
is of particular importance to the Emergency department for patient
triaging and to anesthesiologists who are managing high risk patient
undergoing non cardiac surgery. Troponin I is more specific for cardiac
injury than CK-MB. What does this increased specificity add to decision
making in the above two cases?
Laboratory
management:
Today's hospital clinical laboratories are being asked to continually
improve efficiency. The natural end result of reducing manpower
is to total automate most 24 hour laboratory testing. We are developing
a Consolidated Laboratory which will combine all 24 hour function
of Hematology and Chemistry as well all centralize most automatable
testing.
General
Clinical chemistry:
I am interested in method development and automation of manual method
for routine and special chemistry.
Publications:
- Whelan,
P. V., and Malkus, H., A macro creatine kinase isoenzyme in serum
of apparently healthy individuals. Clin. Chem. 29, 1411-1414 (1983).
- Smith,
J.D., Nobiletti, J., Freed, M., Malkus, H., and Donabedian, R.
Interference with the ASTRA 8 and Synchron CX3 assays of urea
nitrogen in serum by a high-Mr inhibitor in a patient with multiple
myeloma. (letter) Clin. Chem., 38, 598-599(1992).
- Rinder,
H. M., Snyder, E. L., Bonan, J. L., Napychank, P. A., Malkus,
H., Smith, B. R. Activation in stored platelet concentrates: Correlation
between membrane expression of P-selectin, GPIIb/IIIa, and b-thromboglobulin
release. Transfusion 1993;33:25-29.
- Roberts,
W. L., Santos, F. S., Rainey, P. M., and Malkus, H. Prevention
of erroneous results with diluted EMITŪ reagents in critically
ill patients. Clin. Chem.,1994;1597-1598.
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