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Brigitte P. Griffith, PhD

Clinical Professor of Laboratory Medicine
Director, VA Reference Virology Laboratory
203-937 3441
brigette.griffith@yale.edu

Pharmacy, 1971, University of Strasbourg, France
Ph.D., 1974, University of Strasbourg, France
Fellowship: Clinical Virology and Immunology, Yale University School of Medicine


Community of Science Biosketch

Research Interests
Although therapy for the human immunodeficiency virus (HIV) is now widely used, the optimal algorithm for efficient use of the numerous types of anti-HIV agents available remains unclear. Prognostic markers that are currently utilized for following individuals undergoing HIV therapy include CD4+ T cells, viral load and resistance testing. The goal of my present work is to evaluate the usefulness of genotyping resistance testing in HIV infected individuals treated with antiretroviral agents.

1. Lin PF, Gonzales CJ, Griffith BP, Friedland G, Calvez V, Ferchal F, Schinazi RF, Shepp DH, Ashraf Ab, Wainberg M, Soriano V, Mellors JW, Colonno RJ. Stavudine resistance: an update on susceptibility following prolonged therapy. Antiviral Therapy: 4:21-28, 1999.
   
2. Friedland G, Pollard R, Griffith BP, Hughes M, Morse G, Bassett R, Freimuth W, Demeter L, Connick E, Nevin T, Hirsch M, Fischl M, for the ACTG 261 Team. The efficacy and safety of Delavirdine Mesylate with Zidovudine and Didanosine in persons with HIV disease with CD4 cell counts from 100-500 cells/mm3 (ACTG 261). J Acquir Immun Defic Syndr Hum Retrovirol 21: 281-292, 1999.