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Stephen
C. Edberg, PhD, ABMM
Professor
of Laboratory Medicine
Director of Microbiology, Y-NHH
203-688-2457
stephen.edberg@yale.edu
1967,
B.A., Lehigh University
1971, Ph.D., SUNY at Buffalo
Fellowship: University of Washington; NIH
Research
Interests
My research is primarily focused on which characteristics of bacteria
make them virulent for human beings. In particular, I am interested
in bacteria that are found in the environment that may cause infection
in human beings. To determine the virulence characteristics of bacteria,
my laboratory has examined a wide variety of bacterial species from
the environment and from human clinical infections to determine
the most important characteristics associated with invasiveness.
The bacteria have been analyzed based on metabolic activity, enzyme
production, the ability to attach to and to penetrate into cells
and the ability to produce certain DNA sequences that are associated
with virulence. My laboratory is now engaged in a major Centers
for Disease Control project on the examination of the causes of
diarrhea. Patient specimens and age-matched controls are examined
for three groups: those which are known; those which are suspected;
and those which are speculative. In addition, normal flora bacteria
are screened for antibiotic resistance. The Clinical Microbiology
laboratory also engages in collegial research with both basic and
clinical investigators. Plus, it generates its own projects for
the residents and fellows.
Clinical Activities
The Clinical Microbiology Laboratory of the Yale-New Haven Hospital
is a full service operation, performing extent 4 (highest) level
analyses in Bacteriology, Mycology, Mycobacteriology, and Parasitology.
(Click here for a description
of Clinical Virology). It maintains an active ACGME approved Clinical
Microbiology fellowship program. Clinical Adult and Pediatric
Infectious Diseases rounds begins each day in the Laboratory by
the presentation and discussion of cases with the attendings, fellows,
and residents.
- Vielemeyer O. Crouch JY. Edberg SC. Howe JG. Identification
of Bordetella pertussis in a critically ill human immunodeficiency
virus-infected patient by direct genotypical analysis of Gram-stained
material and discrimination from B. holmesii by using a unique
recA gene restriction enzyme site. Journal of Clinical Microbiology.
42(2):847-9, 2004 Feb.
- Rakoff-Nahoum, S., Paglino, J., Eslami-Varzanch, F., Edberg,
S., Medzhitov, R. Recognition of commensal microflora by toll-like
receptors is required for intestinal homeostasis. Cell. 229-241,
2004
- Edberg, S.C. and Allen, M.J. Virulence and risk from drinking
water of heterotrophioc plate count bacteria in human population
groups. International Journal of Food Microbiology 92:255-263,
2004
- Allen, M.J., Edberg, S.C., and Reasoner, D.J. Heterotrophic
plate count bacteria - what is their significance from drinking
water. International Journal of Food Microbiology, 265-274.,
2004
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