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Table of Contents

APC Resistance

Synonym:    Activated Protein C Resistance, Blood

Methodology:    PTT-based assay

Schedule:    Once/week

Reported:    3-5 days

Laboratory:    Hematology

 

SPECIMEN REQUIREMENTS     

Collection Requirements:    Preferred container is 4.5-mL blue top tube; pediatric 2.7-mL blue top tube is also acceptable. Tube must be filled completely.

Unacceptable Conditions:    Partially filled tube or clotted sample

 

INTERPRETIVE INFORMATION     

 

Reference Interval

MaterialSexAge RangeLimits
 Blood (Citrate)All ages> 2.20 Ratio

Reference Range Comment:    


    Ratio >2.20 rules out APC resistance and factor V Leiden gene mutation.

 

Clinical Indication Criteria:    Unexplained thrombosis. The most frequent cause of APC resistance is factor V Leiden gene mutation.

Tests In This Panel:   

Test # Name
Material Sex Age Range Limits
Prothrombin Time
Blood (Citrate)7 Days old and up9.7 - 12.1 seconds
2054PTT
Blood (Citrate)All ages22 - 35 seconds
APC Resistance
Blood (Citrate)All ages> 2.20 Ratio
Special Coagulation Interpretation
    
2078INR (International Normalized Ratio)
Blood (Citrate)All ages0.8 - 1.2

Manual Release Date:    10/16/2009

Format Date:    11/02/2009

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