Case Study #7   1  2  3  4  5  6  7  8  9  10  11  12  13   Brain Biopsy - Histopathologic Interpretation NO classical HSV-associated changes (inclusions), BUT: THERE IS NOTED: perivascular cuffing by a mononuclear cell infiltrate dead/dying neurons areas consistent with glial nodules neuronophagia (clusters of cells around dying neurons) Interpretation: There are some features of HSV infection; need to rule out lymphoma (Booss J and Kim JH. Yale J Biol Med 57:751, 1984) Breakpoint #6 What additional studies would you suggest at this time?