Case
Study #7
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HSV-1
Histopathology
 
COURTESY
OF Dr. Peter Anderson, University of Alabama at Birmingham
Department of Pathology
http://peir.net/
HSV-1 Ultrastructure
Herpes
virus assembled in the nucleus. (Courtesy of Dr. Duncan
Wilson)
http://www.aecom.yu.edu/aif/gallery/TEM/tem.htm
HSV-1
and Encephalitis
- icosahedral,
linear double-stranded DNA genome
- HSV-1
and HSV-2 show 50% sequence homolgy
- consists
of viral genome in capsid with lipid envelope
- reactivation-trigeminal,
primary-olfactory
-
HSV-1 accounts for 95% of viral encephalitis in US
- 1/200,000
people per year (1250 people per year in US)
-
70% mortality rate in untreated encephalitis
- so
prompt therapy is important
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