Case Study#6   1  2  3  4  5  6  7  8  9  10  11  12  13  14  15  16   Treatment Of Bleeding With FX Deficiency Half-life of factor X is 24-48 hrs Fresh frozen plasma - 10-20 cc/Kg loading dose - 3-6 cc/Kg twice daily - Aim to keep factor levels >10-20% Selected References Cooper DN, Millar DS, Wacey A, Pemberton S, Tuddenham EG. "Inherited factor X deficiency: molecular genetics and pathophysiology." Thromb Haemost. 1997 Jul;78(1):161-72. Hertzberg M. "Biochemistry of factor X." Blood Rev. 1994 Mar;8(1):56-62. Peyvandi F, Menegatti M, Santagostino E, Akhavan S, Uprichard J, Perry DJ, Perkins SJ, Mannucci PM. "Gene mutations and three-dimensional structural analysis in 13 families with severe factor X deficiency." Br J Haematol. 2002 Jun;117(3):685-92. Uprichard J, Perry DJ. "Factor X deficiency." Blood Rev. 2002 Jun;16(2):97-110. Figure acknowledgements Figures on pages 11 and 12 are from McClatchey's "Clinical Laboratory Medicine", 2nd ed., 2002 and from Cooper et al. Thromb Haemost. 1997 Jul;78(1):161-72.