Case Study#6   1  2  3  4  5  6  7  8  9  10  11  12  13  14  15  16   Factor X Deficiency Congenital or Acquired Congenital: autosomal recessive Variable bleeding tendency at any age - Severe (<1%): umbilical stump bleeding - Less severe: post-hemostatic challenge - Mildly affected: bruising, menorrhagia Heterozygotes (1:500 incidence) Usually asymptomatic Rarely have bleeding thought to be 2° to either: - Insufficient enzymatic activity of wild type - Inhibitory or competitive effect of mutant Homozygotes (1:1,000,000) One of the rarest inherited clotting disorders Patients are usually seriously affected More frequent in consanguineous marriages