Case Study#6   1  2  3  4  5  6  7  8  9  10  11  12  13  14  15  16   Factor X Deficiency Vitamin K Metabolic Pathway Duckert et al (1954) - Factor deficiency in pts on coumarins, distinct from factor VII and factor IX Factor X named (1962) Vitamin K dependent serine protease Factor X Gene 13q34ter, 22 kb - 2.8 kb downstream of FVII gene Structure and sequence homologous to other vitamin K dependent factors Eight exons, seven introns   Factor X Protein Hepatic synthesis Two chain protein in plasma, 59 kd - 139 AA, 16.9 kd - 346 AA, 42.1 kd Concentration in plasma 10 mg/mL Eight functional domains