Case Study#5   1  2  3  4  5  6  7  8  9  10  11  12  13  14  15  16   von Willebrand's Disease (vWD) Type I - usually mild-moderate disease; heterozygous mutation - quantitative deficiency of all multimer sizes Type II - usually mild-moderate; heterozygous mutation - qualitative abnormality of vWF resulting in decreased high MW multimers Type III - severe vWD; absent vWF due to inheritance of two abnormal vWF alleles (homozygote or compound heterozygote) Clinical manifestations Mucocutaneous bleeding epistaxis 60% easy brusing, hematomas 40% menorrhagia 35% gingival bleeding 35% GI bleeding 10% Bleeding is common after trauma dental extractions 50% trauma/wounds 35% post-partum 25% post-operative 20%