Case Study#5   1  2  3  4  5  6  7  8  9  10  11  12  13  14  15  16   Secretion of vWF Constitutive dimer and small multimers (pro-vWF and mature wWF) Stimulus-induced release from WP bodies (large multimers, mostly mature vWF) induced by: thrombin histamine fibrin C5b-9 (complement membrane attack complex) O2 radicals release from platelets (vWF stored in a-granules) after: thrombin ADP Collagen vWF function In plasma, the predominant MW is b/w 500,000-20,000,000 The bigger the multimer: more platelet and collagen binding sites more hemostatically competent