Case Study#5   1  2  3  4  5  6  7  8  9  10  11  12  13  14  15  16   Other Possible Pathophysiology Antibody binding a functional site on vWF Adsorption to tumor cells (prostate CA) vWF noted within tumor cells in some reports removal of tumor curative in some cases Increased proteolytic degradation of vWF by drugs (not in this patient) Disorders associated with acquired vWD Monoclonal gammopathy 42% MGUS myeloma B-cell Lymphoproliferative disorders 15% non-Hodgkin's lymphoma CLL Myeloproliferative disorders 10% Wilms tumor, Adrenocortical CA 8-10 % Drugs (Valproic acid, Cipro) 7% Hypothyroidism 5% Aortic stenosis Angiodysplasia }<10% Unknown