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Mapping
the Papillary Renal Cell Carcinoma Gene Between Loci D17S787 and D17S1799
on Chromosome 17q21.32 |
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Ildiko Balint,
Joachim Fischer, Börje Ljungberg, and Gyula Kovacs |
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Laboratory
of Molecular Oncology (IB, JF, GK), Department of Urology, Ruprecht-Karls-University,
Heidelberg, Germany; and Department of Urology (BL), University of Umea,
Umea, Sweden |
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SUMMARY: Trisomy of chromosome
17 is associated with the development of papillary renal cell tumors (RCT).
We have analyzed 37 papillary RCT by applying 25 polymorphic microsatellite
markers and found an overlapping duplication including loci D17S1795 and
D17S1306 on chromosome 17q21. This region was then analyzed in additional
118 sporadic and hereditary papillary RCT. Overlapping partial duplications
at the chromosome 17q21.32 region localized the papillary RCT gene to an
approximately 300 kb genomic sequences flanked by loci D17S787 and D17S1799.
Altogether, 92% of the 100 papillary RCT showed allelic duplication
at this region. We did not find mutation in coding sequences or altered
expression of the hepatic leukemia factor gene, which is mapped the smallest
duplicated interval, in any type of RCT. Therefore, another gene within
the 300 kb region might be responsible for the development of papillary
RCT. |
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