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Correlation
of Major Histocompatibility Complex with Opportunistic Infections in Simian
Immunodeficiency Virus-Infected Rhesus Monkeys |
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Gary B. Baskin,
Ronald E. Bontrop, Henk Niphuis, Riet Noort, Janet Rice, and Jonathan L.
Heeney |
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Department
of Pathology (GBB), Tulane Regional Primate Research Center, Tulane University,
Covington, and Department of Biostatistics and Epidemiology (JR), School
of Public Health and Tropical Medicine, Tulane University, New Orleans,
Louisiana; and Department of Immunobiology (REB, RN) and Laboratory of Viral
Pathogenesis, Department of Virology (HN, JLH), Biomedical Primate Research
Centre, Rijswijk, The Netherlands |
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The role of the major histocompatibility
complex (MHC) in the pathogenesis of AIDS is complex because of compounding
variables within the virus, host, and environment. Important variables can
be controlled by using the experimental animal model of AIDS induced by
simian immunodeficiency virus in rhesus monkeys (Macaca mulatta). We studied
whether the MHC type influenced which opportunistic infections arose in
an individual monkey. Several associations were found. For example, cytomegalovirus
was strongly associated with Mamu-B6 (p < 0.001), whereas Cryptosporidium
was associated strongly with Mamu-DR3 (p < 0.001). We also found that
having one opportunistic infection increased the risk of having another.
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